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991.
Matsumoto T Takeji S Asagi A Kajiwara T Nishina T Hori S Ikeda Y Nadano S Iguchi H 《Nihon Shokakibyo Gakkai zasshi》2011,108(12):2003-2009
Pancreatic cancer shows the worst prognosis among the solid tumors, and survival for patients with high-grade liver metastasis is estimated at around a few months. We reported the effects of combination therapy with gemcitabine and S-1 (GS therapy) on pancreatic cancer patients with high-grade hepatic metastasis. Patients with severe metastatic pancreatic cancer received chemotherapy comprising S-1 (30mg/m2 p.o. b.i.d., days 1-14) and gemcitabine (1000mg/m2 on days 1 and 8), repeated every 3 weeks. Fourteen patients (7 men, 7 women) received treatment at a mean age of 56.5 years (range, 39-76 years), achieving complete response in 1 patient, partial response in 5 patients, and stable disease in 3 patients and progressive disease in 5 patients. The response rate was thus 43%. Median progression-free survival was 186 days (95% confidence interval, 40-247 days). Median overall survival was 261 days (95% confidence interval, 162-358 days). GS therapy appears to be well-tolerated and effective in patients with high-grade hepatic metastasis. 相似文献
992.
Satoru Nanno Hideo Koh Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Masahiko Ohsawa Masayuki Hino Hirohisa Nakamae 《Journal of Clinical and Experimental Hematopathology》2021,61(2):93
Acute fibrinous and organizing pneumonia (AFOP) is a rare acute lung injury featuring pathological intra-alveolar fibrin balls and organizing pneumonia without hyaline membranes or eosinophils. AFOP forms acute and subacute patterns; the former often has a poor prognosis, whereas the latter has better survival. Secondary hemophagocytic syndrome (HPS) is a cytokine-related and potentially lethal disorder induced by various diseases, and pulmonary involvement in HPS is not rare. However, to our knowledge, no report has addressed the association between secondary HPS and AFOP development. We report two cases of subacute AFOP following HPS in hematological malignancies. 相似文献
993.
994.
Yoko Hoshi Jinghua Huang Shunji Kohri Yoshinobu Iguchi Masayuki Naya Takahiro Okamoto Shuji Ono 《Journal of neuroimaging》2011,21(2):e94-e101
ABSTRACT
BACKGROUNDS AND PURPOSE
The aim of this study is to develop a near‐infrared spectroscopy (NIRS)‐based system that recognizes pleasant and unpleasant human emotions based on cerebral blood flow (CBF) in order to understand the minds of patients whose brain function is severely impaired. The forehead region is easily accessible to NIRS measurements, whereas the role of the anterior prefrontal cortex (PFC) in the processing of emotion remains to be elucidated.METHODS
Initially, using event‐related NIRS we examined changes in oxygenated hemoglobin (oxy‐Hb) as an indicator of regional CBF changes, which reflect brain activity directly related to emotions, but not to cognitive operations in the anterior frontal regions, during viewing affective pictures. The event‐related potentials (ERPs), systemic blood pressure, and pulse rate were also measured simultaneously.RESULTS
The event‐related analysis of changes in oxy‐Hb for a 6 s‐picture presentation period showed that very unpleasant emotion was accompanied by an increase in oxy‐Hb in the bilateral ventrolateral PFCs, while very pleasant emotion was accompanied by a decrease in oxy‐Hb in the left dorsolateral PFC. There were no significant differences in either ERPs or autonomic nervous system activities between the two emotional states.CONCLUSION
These findings suggest the possibility of recognizing patients’ emotions from CBF changes.995.
Kohsaka M Kanemura T Taniguchi M Kuwahara H Mikami A Kamikawa K Uno H Ogawa A Murasaki M Sugita Y 《Expert Review of Neurotherapeutics》2011,11(10):1389-1397
The aim of this study was to evaluate the efficacy and safety of ramelteon 4, 8, 16 or 32 mg and placebo in Japanese patients with chronic insomnia using a randomized, double-blind, five-period crossover design. A total of 65 Japanese patients with chronic primary insomnia received ramelteon or placebo for two nights each in sleep laboratories. Changes in sleep parameters were assessed objectively by polysomnography and subjectively by postsleep questionnaires. Safety and tolerability was evaluated by assessment of the occurrence of adverse events, next-day residual effects and laboratory and ECG investigations. Ramelteon 8 and 32 mg significantly shortened the mean latency to persistent sleep in comparison with placebo, and there was a statistically significant trend for linear dose-response for this sleep parameter. Overall changes in sleep architecture were modest (<3% changes vs placebo), with increases in stage 1 and decreases in stage 3/4. Ramelteon was well tolerated, the most common adverse effect being somnolence, which was similar to placebo at doses up to 8 mg, but increased with higher doses. Next-day residual effects occurred no more frequently with ramelteon at any dose than with placebo. When compared with sleep latency data from a similarly-designed US study, there was no evidence of any ethnic differences in the efficacy of ramelteon between Japanese and US patients. Overall, ramelteon 8 mg showed the most favorable balance between sleep-promoting effects and tolerability. The unique efficacy profile of ramelteon, promoting sleep initiation without affecting other sleep parameters, may be due to its circadian shifting effect. 相似文献
996.
Tadahiro Nozoe M.D. Tomohiro Iguchi M.D. Akinori Egashira M.D. Eisuke Adachi M.D. Akito Matsukuma M.D. Takahiro Ezaki M.D. 《American journal of surgery》2011,201(2):186-191
Background
The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully.Methods
Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0.Results
There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis.Conclusions
The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma. 相似文献997.
Ishida K Tsumura N Kitagawa A Hamamura S Fukuda K Dogaki Y Kubo S Matsumoto T Matsushita T Chin T Iguchi T Kurosaka M Kuroda R 《International orthopaedics》2011,35(11):1639-1645
Purpose
This is a randomised controlled trial to examine whether intra-articular injection of tranexamic acid (TXA) decreases blood loss, as well as reducing leg swelling after total knee arthroplasty (TKA).Methods
We performed 100 TKA in osteoarthritis patients. At closure, a total of 2,000 mg/20 ml TXA was injected into the knee joint through a closed suction drain (TXA group). For the control group, the same volume of physiological saline was injected. The pre-operative condition of the patients, post-operative haemoglobin (Hb) levels, discharge volumes from drain, D-dimer and needs for transfusion were compared between these two groups. Furthermore, leg diameters (thigh, suprapatellar portion and calf girth) were measured pre- and post-operatively to investigate whether TXA has an influence on leg swelling after surgery.Results
The results revealed that post-operative decrease in Hb level was significantly reduced in the TXA group. Furthermore, knee joint swelling after operation was significantly suppressed in the TXA group compared to the control group.Conclusions
The results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA. 相似文献998.
Miura T Goto S Iguchi S Shimada H Ueno M Nishi S Narita I 《Clinical and experimental nephrology》2011,15(1):86-91
Background
Arg95Stop mutation of exon 4 in complement component 9 (C9) gene is common in individuals in Japan with C9 deficiency (C9D); however, understanding of the influences of C9D on human glomerulonephritis remains elusive. 相似文献999.
1000.
Shimoyama T Kimura K Iguchi Y Shibazaki K Watanabe M Sakai K Sakamoto Y Aoki J 《Journal of the neurological sciences》2011,310(1-2):40-43
PET and SPECT are very sensitive techniques to detect in-vivo nigrostriatal degeneration in Parkinson's disease, even in the pre-motor phase of the disease. Furthermore, these techniques are able to measure disease progression. However, caution must be used in the interpretation of studies in which therapeutic effects in Parkinson's disease were also monitored by serial imaging of nigrostriatal neurons, as disparity between imaging and clinical outcomes has been reported in several clinical studies. 相似文献