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排序方式: 共有794条查询结果,搜索用时 15 毫秒
71.
Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response 总被引:1,自引:0,他引:1
Penttilä T Haveri A Tammiruusu A Vuola JM Lahesmaa R Puolakkainen M 《Microbial pathogenesis》2008,45(1):25-29
In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both ex vivo induced antigen-specific proliferation as well as production of proinflammatory cytokines by splenocytes were higher in IL-10 KO mice than in WT mice. Also, intrapulmonary proinflammatory cytokine levels were higher in IL-10 KO mice than in the WT mice. The lack of anti-inflammatory action of IL-10 is likely to contribute to the enhanced clearance but severe inflammation in this experimental model. 相似文献
72.
Mirja Sargent Stefan Boeck Volker Heinemann Karl-Walter Jauch Thomas Seufferlein Christiane J. Bruns 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2011,396(2):223-229
Background
To date, only limited data are available regarding the routine surgical management of patients with exocrine pancreatic cancer (PC) in German community and university hospitals. 相似文献73.
Irja Vent? Ani Lakoma Sauli Haahtela Jaakko Peltola Pekka Ylipaavalniemi Lauri Turtola 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,99(5):546-549
OBJECTIVE: The aim of the study was to examine oral piercings among first-year university students. STUDY DESIGN: First-year university students in 2002 were invited to a dental examination (n = 234; 49 men and 185 women). Students with piercings formed the study group and the rest served as controls. The methods included decayed, missing, and filled teeth (DMF) index, stimulated salivary flow rates, panoramic tomograms, and questionnaires including the Depression Inventory of Beck. Fisher's 2-sided exact test was used for statistical analysis. RESULTS: The prevalence of oral piercings was 3.4%. In the DMF indices, no statistically significant differences existed between the groups. Increased salivary flow rates were noted among students with piercings (63% vs 26%, P < .05). Use of tobacco and illicit drugs, and also depression, were more prevalent in the study group than in the controls. CONCLUSION: Because of the possibility of oral implications, follow-up of oral piercings is essential. 相似文献
74.
I Roine A Banfi P Bosch W Ledermann C Contreras H Peltola 《The Pediatric infectious disease journal》1991,10(12):923-928
Quantitative C-reactive protein (CRP) was determined sequentially by nephelometry and photometry from a finger prick serum sample in 67 children with bacterial meningitis (BM) and 16 children with aseptic meningitis (AM). The initial mean CRP value of 180 mg/liter in children with BM differed significantly from the 12 mg/liter found in those with AM (P less than 0.001). In BM a slow descent instead of rapid normalization or a secondary increase in sequential CRP values were early indicators of complications during recovery, such as resistance to the antibiotic. A significant difference in the mean CRP values between uneventful and complicated courses of BM was observed from the fourth day on (P less than 0.001). The measurements obtained with nephelometry correlated reliably with the more widely available photometry (r = 0.99). Easily performed rapid CRP determinations can considerably improve the quality of care in meningitis patients, especially in those situations where facilities for performing bacterial cultures or antibiotic susceptibility testing are not available. 相似文献
75.
Surveillance of blood-culture-proven epiglottitis was conducted in Finland from 1985 through 1992. Among children (<16 years), all bacteria causing epiglottitis, and among adults, Haemophilus influenzae were included. H influenzae type b (Hib) caused 226 (97%) of cases among children. Among adults with H influenzae epiglottitis (total of 20), 19 were caused by Hib In 1986, vaccine trials with Hib-conjugate vaccines started in Finland, with vaccination coverage of 94% to 98% of infants. Vaccinations did not yet have an effect on the occurrence of epiglottitis in 1985 or 1986 when the annual incidence among children was 5.3/100, 000, among those less than 5 years of age was 13.2/100, 000, and among adults was 0.08/100, 000. In 1987 through 1992 the proportion of vaccinated children increased steadily while the incidence of Hib epiglottitis decreased from 50 to 60 cases seen annually in 1985 and 1986 to 2 cases in 1992. There was no increase in the occurrence of epiglottitis caused by other pathogens In conclusion, there is now a safe and efficient way to prevent the majority of epiglottitis cases among children with the new Hib-conjugate vaccines. 相似文献
76.
77.
Annukka Holster Johanna Teräsjärvi Eero Lauhkonen Sari Törmänen Merja Helminen Petri Koponen Matti Korppi Ville Peltola Qiushui He Kirsi Nuolivirta 《Allergology international》2018,67(1):109-113
Background
Interleukin-17 (IL-17A) is a mainly pro-inflammatory cytokine, and IL-17 signaling implicates in the development of allergic asthma. The polymorphism rs2275913 in the promoter region of the IL-17A gene has in previous studies been associated with asthma susceptibility. The objective was to evaluate the association between IL-17A rs2275913 (-197G>A) polymorphism and post-bronchiolitis asthma and/or allergic rhinitis in a prospective 11–13 years post-bronchiolitis follow-up.Methods
166 previously healthy full-term infants, hospitalized for bronchiolitis at age less than 6 months, were invited to follow-up visits at the ages of 5–7 years and 11–13 years. Asthma diagnoses and presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Blood samples for IL-17A rs2275913 (-197G>A) polymorphism were obtained during hospitalization or at the 5–7 years control visit.Results
There were no significant differences between children with the wild GG and variant GA or AA genotype in the severity of bronchiolitis during hospitalization or in the outcomes until the age 5–7 years. At 11–13 years of age, children with the variant GA or AA genotype had significantly less often current asthma, use of ICSs during last 12 months or allergic rhinitis than those with the wild GG genotype. The ICS use during last 12 months retained the statistical significance in adjusted analyses (adjusted OR 0.25), whereas current asthma and allergic rhinitis marginally lost it.Conclusions
The IL-17A rs2275913 (-197G>A) polymorphism decreased the risk of post-bronchiolitis asthma at 11–13 years of age, but not earlier in life, in the present prospective, long-term follow-up study. 相似文献78.
79.
Late psychiatric morbidity in survivors of cancer at a young age: A nationwide registry‐based study 下载免费PDF全文
Ritva Ahomki Mirja E. Gunn Laura M. Madanat‐Harjuoja Jaakko Matomki Nea Malila Pivi M. Lhteenmki 《International journal of cancer. Journal international du cancer》2015,137(1):183-192
Childhood cancer survivors have been shown to be prone to psychosocial adverse outcomes. Data on young adults and their psychiatric late effects are still scarce. In a nationwide, registry‐based study, we explored the risk (HR) of new psychiatric diagnoses in 5‐year survivors of childhood and young adulthood (YA) cancer (n = 13,860) compared with a sibling cohort (n = 43,392). Hazard ratios (HRs) were calculated using Cox regression models. Patients and siblings were identified from the Finnish Cancer Registry and Central Population Registry, respectively. Outcome diagnoses were retrieved from the national hospital discharge register. The risk of organic memory/brain disorders was significantly increased in both childhood (HR 4.9; 95%CI 2.7–8.9) and YA (HR 2.1; 95%CI 1.4–3.1) cancer survivors compared with siblings. Mood disorders were also more common in childhood (HR 1.3; 95%CI 1.1–1.7) and YA survivors (1.3; 95%CI 1.1–1.5) than in siblings. Radiotherapy did not explain the differences. Female childhood cancer survivors had significantly increased HRs for mood disorders, psychotic disorders, neurotic/anxiety disorders, somatization/eating disorders and personality disorders. In survivors of YA cancers, females had significantly increased HR for neurotic/anxiety disorders, and the difference between female survivors and siblings was significantly (p < 0.05) higher than that between male survivors and male siblings. The effect of treatment era was also analyzed, and the risk of organic memory and brain disorders in childhood cancer survivors did not diminish over time. Despite the trend of decreased use of cranial irradiation in children, the risk of organic memory/brain disorders was elevated, even during the most recent era. Thus, additional research on chemotherapy‐only protocols and their impact on mental health, is warranted. 相似文献
80.
Helama S Bégin Y Vartiainen M Peltola H Kolstr?m T Meril?inen J 《Applied radiation and isotopes》2012,70(6):1014-1023
We analyzed how the pretreatment method of Scots pine (Pinus sylvestris L.) wood specimens together with X-ray methodology applied for density analyses affect resulting tree-ring data and derived proxy-based climate information. We also evaluated whether these results from two contrasting laboratory circumstances could be homogenized by applying dendroclimatic statistical methods. For this study, we measured a pair of X-ray based microdensitometry datasets using double samples of subfossil and recent wood specimens. Dendrochronological information of earlywood and latewood series was examined to determine for alterations in the resulting data. We found that the level of overall density, its trend over cambial ages and the growth amplitude altered due to the sample pretreatment/density measuring exercise, which means that comparisons of heterogeneous datasets should be, in general, regarded cautiously. Dendrochronological standardization did, however, even out several potentially biasing influences from the differing overall densities and their trends. The two latewood (maximum) density chronologies yielded paleoclimatic reconstructions which both calibrated and verified satisfactorily with the instrumental warm-season (March-September) mean temperatures. The transfer functions were found to further equalize the differences between the two proxy records. We recommend (if no strictly homogenous data are available) reconciling similar data assemblages through transfer functions with multiple independent variables. 相似文献