Richard钉治疗高龄股骨转子间骨折

目的：介绍Richard钉治疗高龄股骨转阳骨折手术体会。方法,用国产Richard钉治疗不同类型高龄股骨转子间骨折50例。结果 随访45例,平均时间2年11个月,优良率95．6％,术后并发症发生率40％。结论 Richard钉是治疗高龄股骨转子间骨折的较好方法,高龄股骨转子间骨折应早期手术治疗,术后重视深静脉血栓的预防。     

Effect of Rolling Temperature on Microstructure and Properties of Al-Mg-Li Alloy

In this study, the effects of hot-rolled processes at different temperatures (420 °C, 450 °C, and 480 °C) and subsequent solid solution and aging treatments on the microstructure, mechanical properties, and corrosion properties of Al-Mg-Li alloys with trace Sc and Zr addition were investigated. The aging treatment of rolled sheets after solid solution treatment could obtain Al₃Li particles and Al₃(Sc, Zr)/Al₃Li core–shell particles to improve the mechanical properties of Al-Mg-Li alloy products effectively. The results showed that, as the rolling temperatures increased from 420 °C to 480 °C, the alloy’s ultimate tensile strengths and yield strengths increased, while the corrosion resistance decreased. The increase in rolling temperature increased the precipitation-free zone (PFZ) width of the alloy, which undermined the corrosion resistance of the alloy. Moreover, elevating the hot rolling temperature changes the texture strength of the alloy. Particularly in the 480 °C hot-rolled sample, the decrease in the Brass texture strength and the increase in the S texture and Copper texture strength led to an increase in the Taylor factor (M). The increase in rolling temperature also raised the number density of the Al₃(Sc, Zr)/Al₃Li core–shell particles. The presence of such particles not only inhibits grain growth but also changes the strength mechanism from dislocation cutting to Orowan bypassing. Due to the combination effect of grain morphology, texture evolution, and precipitation behavior, the 480 °C hot-rolled sample had the highest properties.     

多层螺旋 CT 在评估食管出血危险性中的应用价值

目的：探讨多层螺旋CT在评估食管出血危险性中的应用价值。方法选择肝硬化后食管静脉曲张患者50例,均行多层螺旋CT和胃镜检查,并以胃镜检查结果为标准评价多层螺旋CT在评估食管出血危险性中的应用价值。结果 CT血管成像评分与胃镜静脉曲张程度、胃镜红色征的严重程度均呈显著的正相关（r＝0．762、0．687,均P＜0．01）,CT血管成像评分诊断胃镜红色征的RC 3的敏感性为76．92％,特异性为92．50％。结论多层螺旋CT与胃镜检查结果对食管静脉曲张严重程度的分级呈显著相关性,可以用来预测食管出血的危险性。     

Exploration of Hanshi Zufei prescription for treatment of COVID-19 based on network pharmacology

Objective: Network pharmacology combines drug and disease targets with biological information networks based on the integrity and systematicness of the interactions between drugs and disease targets. This study aims to explore the molecular basis of Hanshi Zufei formula for treatment of COVID-19 based on network pharmacology and molecular docking techniques. Methods: Using TCMSP, the chemical constituents and molecular targets of Atractylodis Rhizoma, Citri Reticulatae Pericarpium, Magnoliae Officinalis Cortex, Pogostemonis Herba, Tsaoko Fructus, Ephedrae Herba, Notopterygii Rhizoma et Radix, Zingiberis Rhizoma Recens, and Arecae Semen were investigated. The predicted targets of novel coronavirus were screened using the NCBI and GeneCards databases. To further screen the drug-disease core targets network, the corresponding target proteins were queried using multiple databases (Biogrid, DIP, and HPRD), a protein interaction network graph was constructed, and the network topology was analyzed. The molecular docking studies were also performed between the network’s top 15 compounds and the coronavirus (SARS-CoV-2) 3CL hydrolytic enzyme and angiotensin conversion enzyme II (ACE2). Results: The herb-active ingredient-target network contained nine drugs, 86 compounds, and 49 drug-disease targets. Gene ontology (GO) enrichment analysis resulted in 1566 GO items (P < 0.05), among which 1438 were biological process items, 35 were cell composition items, and 93 were molecular function items. Fourteen signal pathways were obtained by enrichment screening of the KEGG pathway database (P < 0.05). The molecular docking results showed that the affinity of the core active compounds with the SARS-CoV-2 3CL hydrolase was better than for the other compounds. Conclusion: Several core compounds can regulate multiple signaling pathways by binding with 3CL hydrolase and ACE2, which might contribute to the treatment of COVID-19.     

浅谈小儿推拿处方配穴理论

笔者从中医基础理论入手,介绍了五行生克配穴、穴位连贯配穴、穴位相对配穴、穴性佐制配穴,以及名家经验配穴五种配穴方法的理论来源和临床运用,认为此五种配穴方法对小儿推拿的理论研究和临床指导均有一定的借鉴意义。     

Professional chess expertise modulates whole brain functional connectivity pattern homogeneity and couplings

Brain Imaging and Behavior - Previous studies have revealed changed functional connectivity patterns between brain areas in chess players using resting-state functional magnetic resonance imaging...     

氯硝柳胺在水体及土壤中持效时间及其影响因素的实验研究

目的研究氯硝柳胺在水体及土壤中的持效时间及其影响因素.方法用浸泡杀螺试验和鱼毒试验,观察氯硝柳胺在水体及土壤中持效时间及其影响因素.结果氯硝柳胺在水体中持效时间短,溶液浓度2 mg/L持效时间为3～5 d;持效时间与溶液浓度、环境温度及水中是否含有泥土有关.溶液浓度高,持效时间长,环境温度高及水体中含有泥土持效时间短;阳光照射对水体中的氯硝柳胺持效时间无影响.氯硝柳胺在土壤中持效时间长,60 d内仍保持原有的药效,阳光照射对土壤中的氯硝柳胺持效时间也无影响.结论氯硝柳胺在水体中持效时间短,在土壤中持效时间长.     

低氧性肺动脉高压小鼠肺的环状RNA表达谱研究

目的采用环状RNA(circRNA)芯片筛选低氧性肺动脉高压(HPH)小鼠肺组织中差异表达的circRNA,分析circRNA表达谱特征,为HPH发生机制提供研究方法。方法 20只健康雄性C57BL/6小鼠(体质量17~20 g)按数字表法随机分为HPH模型组与常氧组,每组10只。HPH模型组小鼠置于自制常压低氧舱内,舱内氧浓度(10±0.5)%O2。每天连续低氧处理8 h,连续21 d。常氧组小鼠置于常氧环境饲养。通过测定右心室收缩压和右心肥大指数验证HPH小鼠模型复制成功后,处死小鼠,取肺组织,用circRNA芯片检测各组肺组织circRNA表达谱,并进行组间比较与分析,以明确差异表达的circRNAs。结果与常氧组比较,HPH模型组肺组织中表达显著上调的circRNAs共有23个(P<0.01,P<0.05);表达显著下调的circRNAs共有41个(P<0.01,P<0.05)。结论 circRNA芯片可用于筛选HPH差异表达的circRNA,circRNA可能参与HPH调控机制。