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931.
Rita Calé Rui Campante Teles Manuel Almeida Ingrid do Rosário Pedro Jerónimo Sousa Jo?o Brito Luís Raposo Pedro de Araújo Gon?alves Henrique Mesquita Gabriel Miguel Mendes 《Arquivos brasileiros de cardiologia》2013,101(2):117-126
Background
The clinical benefit of percutaneous coronary intervention (PCI) for long coronary lesions is unclear; furthermore, concerns have been raised about its safety.Objectives
To evaluate the predictors of major adverse cardiac events (MACE) associated with PCI using a full metal jacket (FMJ), defined as overlapping drug-eluting stents (DES) measuring > 60 mm in length, for very long lesions.Methods
We enrolled 136 consecutive patients with long coronary lesions requiring FMJ in our single-center registry. The primary endpoint included the combined occurrence of all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). Demographic, clinical, angiographic, and procedural variables were evaluated using stepwise Cox regression analysis to determine independent predictors of outcome.Results
The mean length of stent per lesion was 73.2 ± 12.3 mm and the mean reference vessel diameter was 2.9 ± 0.6 mm. Angiographic success was 96.3%. Freedom from MACE was 94.9% at 30 days and 85.3% at one year. At the one-year follow-up, the all-cause mortality rate was 3.7% (1.5% cardiac deaths), the MI rate was 3.7%, and the incidence of definite or probable stent thrombosis (ST) was 2.9%. Female gender [hazard ratio (HR), 4.40; 95% confidence interval (CI), 1.81-10.66; p = 0.001) and non-right coronary artery PCI (HR, 3.49; 95%CI, 1.42-8.59; p = 0,006) were independent predictors of MACE at one year. Freedom from adverse events at one year was higher in patients with stable angina who underwent PCI (HR, 0.33; 95%CI, 0.13-0.80; p = 0.014).Conclusions
PCI using FMJ with DES for very long lesions was efficacious but associated with a high rate of ST at the one-year follow-up. However, the rate of cardiac mortality, nonprocedure-related MI, and MACE was relatively low. Target coronary vessel PCI, clinical presentation, and female gender are new contemporary clinical factors that appear to have adverse effects on the outcome of PCI using FMJ for long lesions. 相似文献932.
Lisandra Serra Damasceno Alberto Novaes Ramos Jr Carlos Henrique Alencar Maria Vânia Freitas Gonçalves Jacó Ricarte Lima de Mesquita Anne Taumaturgo Dias Soares Anna Gisele Nunes Coutinho Carolina Cavalcante Dantas Terezinha do Menino Jesus Silva Leitão 《Mycoses》2014,57(7):406-413
Many relapses and deaths resulting from disseminated histoplasmosis (DH) in acquired immunodeficiency syndrome (AIDS) patients have been observed in an endemic area in north‐eastern Brazil. The objective of this study was to evaluate the risk factors associated with the clinical outcomes of DH/AIDS coinfection in patients from the state of Ceará, Brazil. A retrospective cohort of AIDS patients, after their hospital discharge due to first DH episode in the period 2002–2008, was followed until December 31, 2010, to investigate the factors associated with relapse and mortality. A total of 145 patients were evaluated in the study. Thirty patients (23.3%) relapsed and the overall mortality was 30.2%. The following variables were significantly (P < 0.05) associated with relapse and overall mortality (univariate analysis): non‐adherence to highly active antiretroviral therapy (HAART), irregular use of an antifungal, non‐recovery of the CD4+ count and having AIDS before DH; histoplasmosis relapse was also significantly associated with mortality. In the multivariate analysis, non‐adherence to HAART was the independent risk factor that was associated with both relapse (Adj OR = 6.28) and overall mortality (Adj OR = 8.03); efavirenz usage was discovered to be significant only for the overall mortality rate (Adj OR = 4.50). Adherence to HAART was the most important variable that influenced the outcomes in this specific population. 相似文献
933.
934.
da Silva PS Passos RM Waisberg DR Park MV 《Journal of pediatric hematology/oncology》2011,33(1):43-46
Serum sickness is an immune-complex-mediated illness that frequently occurs in patients after polyclonal antibody therapy (thymoglobulin). Although serum sickness has been described secondary to thymoglobulin therapy in adults, there are no reports in children on thymoglobulin-induced acute renal failure. We report a case of serum sickness in a 10-year-old girl who was treated for severe aplastic anemia using rabbit antithymocyte globulin (ATG). Eleven days after being started on antithymocyte globulin treatment, she developed fever, gross hematuria, arthralgia, rash, and acute renal failure. Laboratory results showed decreased complement levels, hypergammaglobulinemia, serum creatinine of 4.8 mg/dL (0.6 mg/dL at baseline), and blood urea nitrogen of 79 mg/dL (28 mg/dL at baseline). Peritoneal dialysis was required for 14 days. The patient's symptoms resolved after 13 days on treatment with a short course of high-dose steroids for 3 days, followed by a prednisolone taper. Early recognition and accurate diagnosis is the key for managing thymoglobulin-induced serum sickness, as treatment is highly effective at achieving good outcomes. 相似文献
935.
936.
Ruth C. Travis Paul N. Appleby Afshan Siddiq Naomi E. Allen Rudolf Kaaks Federico Canzian Silke Feller Anne Tjnneland Nina Fns Johnsen Kim Overvad J. Ramn Quirs Carlos A. Gonzlez Maria‐Jos Snchez Nerea Larraaga Maria‐Dolores Chirlaque Aurelio Barricarte Kay‐Tee Khaw Nick Wareham Antonia Trichopoulou Elisavet Valanou Erifili Oustoglou Domenico Palli Sabina Sieri Rosario Tumino Carlotta Sacerdote H. B. Bueno‐de‐Mesquita Pr Stattin Pietro Ferrari Mattias Johansson Teresa Norat Elio Riboli Timothy J Key 《International journal of cancer. Journal international du cancer》2013,132(8):1901-1910
High dairy protein intake has been found to be associated with increased prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). To further examine this possible relationship, we investigated the hypothesis that a genetic polymorphism in the lactase (LCT) gene might be associated with elevated dairy product intake and increased prostate cancer risk in a case–control study nested in EPIC. The C/T‐13910 lactase variant (rs4988235) was genotyped in 630 men with prostate cancer and 873 matched control participants. Dairy product consumption was assessed by diet questionnaire. Odds ratios (ORs) for prostate cancer in relation to lactase genotype were estimated by conditional logistic regression. Lactase genotype frequency varied significantly between countries, with frequencies of the T (lactase persistence) allele ranging from 7% in Greece to 79% in Denmark. Intake of milk and total dairy products varied significantly by lactase genotype after adjustment for recruitment center; adjusted mean intakes of milk were 44.4, 69.8 and 82.3 g/day among men with CC, CT and TT genotypes, respectively. The lactase variant was not significantly associated with prostate cancer risk, both in our data (adjusted OR for TT vs. CC homozygotes: 1.10, 95% CI: 0.76–1.59) and in a meta‐analysis of all the published data (combined OR for T allele carriers vs. CC homozygotes: 1.12, 0.96–1.32). These findings show that while variation in the lactase gene is associated with milk intake in men, the lactase polymorphism does not have a large effect on prostate cancer risk. 相似文献
937.
938.
Maraya de Jesus Semblano Bittencourt Mario Fernando Ribeiro de Miranda Amanda Magno de Parijós Letícia Brito Mesquita Diana Mendes da Fonseca Diego Augusto Aiezza Jambo 《Anais brasileiros de dermatologia》2013,88(4):614-616
Tattooing has been associated with a variety of complications including inflammatory
and granulomatous reactions, transmission of infections, and neoplasms. We report a
case of a 24-year-old male who presented with a 2-month history of an erythematous
nodule involving a newly made tattoo on the right leg. An excisional biopsy was
performed and the histopathological evaluation was consistent with dermatofibroma.
Only three cases of dermatofibroma associated with tatooing were reported in
litetature. We report an additional case and review the literature regarding
cutaneous reactions to tattoos. 相似文献
939.
Aline Cristina Batista Rodrigues Johann Bruna Gon?alves Garcia Thiago Ribeiro Nacif Jo?o Batista de Freitas Maria Auxiliadora Vieira do Carmo Ricardo Alves Mesquita 《Journal of cranio-maxillo-facial surgery》2006,34(1):57-59
PURPOSE: Osseous choristoma is a rare, benign lesion of the oral cavity and is usually found in the tongue. It presents as a tumour-like mass of normal bony structure with mature cells in an abnormal position. The object of this paper is to report one case of osseous choristoma. PATIENT: A 32-year-old male presented with a lesion in the submandibular region, which was treated by excision. After 28 months of follow-up there was no recurrence. CONCLUSION: Upon reviewing the English literature, no previous case of an osseous choristoma located in the submandibular region has been found. Extended clinical and radiographic follow-up is necessary after surgical excision of an osseous choristoma, despite its benign nature. 相似文献
940.
Diaphragmatic rupture due to trauma is both well recognised and uncommon. The difficulties in diagnosing traumatic diaphragmatic
rupture at the first admission are the most common causes of latent morbidity and mortality. Herniation of the abdominal viscera
is the most common sequel with strangulation and perforation the most serious complication. This case outlines the delayed
presentation of diaphragmatic rupture and herniation presenting as an acute tension faecopneumothorax. We review the relevant
literature, with particular emphasis on the difficulties in diagnosis at presentation. 相似文献