全文获取类型
收费全文 | 375篇 |
免费 | 23篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 34篇 |
妇产科学 | 16篇 |
基础医学 | 50篇 |
口腔科学 | 25篇 |
临床医学 | 46篇 |
内科学 | 73篇 |
皮肤病学 | 7篇 |
神经病学 | 15篇 |
特种医学 | 20篇 |
外科学 | 34篇 |
综合类 | 8篇 |
预防医学 | 18篇 |
眼科学 | 6篇 |
药学 | 21篇 |
中国医学 | 2篇 |
肿瘤学 | 13篇 |
出版年
2022年 | 5篇 |
2021年 | 11篇 |
2020年 | 6篇 |
2019年 | 14篇 |
2018年 | 13篇 |
2017年 | 15篇 |
2016年 | 13篇 |
2015年 | 24篇 |
2014年 | 26篇 |
2013年 | 24篇 |
2012年 | 29篇 |
2011年 | 31篇 |
2010年 | 15篇 |
2009年 | 11篇 |
2008年 | 30篇 |
2007年 | 34篇 |
2006年 | 22篇 |
2005年 | 26篇 |
2004年 | 20篇 |
2003年 | 11篇 |
2002年 | 6篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
排序方式: 共有398条查询结果,搜索用时 15 毫秒
11.
Background: This study aimed to characterize the onset of psychopathological manifestations before dialysis in patients with chronic renal disease, thus contributing to the nursing care of these patients. Subjects and methods: A total of 120 patients registered at the Atatürk University Medical School who fulfilled the eligibility criteria and provided informed consent were included in this study. Results: The majority of the participants, 63.4% were female, 50.0% were 39 years of age or older, 70.0% were married, 80.0% had no current occupation, 56.7% were high school graduates, and 48.3% did not know the cause of their disease. As indicated, 35.0% of the subjects had a depression score over the threshold level, with an average score of 8.53?±?2.45, while patients with scores over the threshold for anxiety made up 53.4%, with an average score of 11.45?±?3.56. Conclusion: This study shows the presence of psychopathological problems before patients are started on dialysis. Therefore, nurses may alleviate pre-dialysis patients’ fears and provide the necessary support to cope with anxiety and depression, thereby raising the patients’ quality of life. 相似文献
12.
13.
An axillary (axillopectoral) muscle (arch) was observed extending between the upper border of the latissimus dorsi and the lower border of the pectoralis major muscles in a 48-year-old male cadaver during our dissections. In the same cadaver, the pectoralis major muscle has entirely inserted into the most distal part of the tendon of deltoideus. © 1996 Wiley-Liss, Inc. 相似文献
14.
Mustafa Akif Sariyildiz Ibrahim Batmaz Mahmut Budulgan Mehtap Bozkurt Levent Yazmalar Ahmet Inanir Tahsin Celepkolu Remzi Çevik 《Rheumatology international》2013,33(8):1973-1979
The aim of this study is to evaluate the relationship between the sleep quality and the disease-related variables, functional status, quality of life, and depressive symptoms in patients with systemic sclerosis (SSc). Forty-eight patients diagnosed with SSc and 42 healthy control subjects were enrolled in the study. The demographic and clinical characteristics of the patients such as the Raynaud’s phenomenon, SSc subtype, digital ulcers, gastrointestinal and lung involvement, and disease activity were recorded. All patients were assessed using the short form 36 (SF-36) quality of life scale, the health assessment questionnaire and the beck depression inventory. Generalized pain and fatigue were assessed with the Visual Analoge Scale. For the evaluation of the sleep disturbance, the SSc and control groups were assessed with the help of the Pittsburgh Sleep Quality Index (PSQI). The patients with SSc had significantly higher scores in the subjective sleep quality, sleep latency, habitual sleep efficiency, sleep disturbance, daytime dysfunction domains, and in terms of the total PSQI score compared to the healthy control group (p < 0.05). According to the results of spearman’s analysis, there was a significantly higher correlation between the generalised pain, fatigue, depressive symptoms, functional status, and physical score of the SF-36 and the sleep disturbance (p < 0.01). There was also a significantly lower correlation between the menopause status, dyspnoea, gastroesophageal reflux, dysphagia, the mental score of the SF-36, and the sleep disturbance (p < 0.05). The sleep quality is disturbed in patients with SSc. The lower quality of sleep is especially associated with the pain, fatigue, depressive symptoms, and functional status. 相似文献
15.
Because of the similarities between Cushing's syndrome and insulin resistance syndrome,cortisol metabolism in obesity has been investigated in numerous studies. Our study investigates serum glucose, insulin, and cortisol response to oral glucose stimulation in a group of obese and lean normotensive, normolipidemic, and glucose-tolerant premenopausal women. Twenty-one obese [body mass index (BMI) 37Z +/- 6.3 kg/m2) and 14 lean (BMI: 21.5 +/- 1.0 kg/m2) age-matched healthy premenopausal women were included in the study. Serum glucose, insulin, and cortisol levels were measured at 30-minute intervals during 120 minutes of oral glucose tolerance testing (OGTT). Mean serum glucose and insulin levels were significantly higher in the obese group compared with lean subjects, and cortisol levels were similar during OGTT. There was not a significant difference for cortisol area under the curve (AUC) during OGTT between the two groups. No correlation between cortisol AUC, insulin AUC, and glucose AUC was noted for both groups. During OGTT, a decrease in cortisol levels was observed in both groups. The decrement occurred at 30 minutes of the OGTT in the obese group and at 60 minutes of the OGTT in the lean group. At 90 and 120 minutes of the OGTT, serum cortisol levels were similar to basal levels in both the obese group and the lean group. Previous studies reported altered hypotalamic-pituitary-adrenal axis activity, altered levels of urinary cortisol excretion, and increased metabolic clearance of cortisol in obesity. In our study in obese women, the only detected difference from lean subjects was a quicker suppression and recovery in serum cortisol levels after glucose administration. 相似文献
16.
Uyar ME Turkay C Erbayrak M Koktener A 《The American journal of the medical sciences》2008,336(1):81-83
Eosinophilia associated with tumors is extremely rare. The exact underlying pathogenetic mechanisms are not well understood; limited data have been reported about granulocyte colony-stimulating factor and interleukin-5 in the development of eosinophilia. We report a patient with marked eosinophilia, leukocytosis, and eosinophilic colitis presenting with bloody stool. The subsequent diagnosis was advanced high-grade transitional cell carcinoma of the bladder. Leukocyte count, eosinophil count, and colonoscopic findings returned to normal after surgical removal of the tumor. To our knowledge, eosinophilic colonic infiltration as a manifestation of transitional cell bladder carcinoma has not been previously reported. 相似文献
17.
Ihsan Yigit Metin Atescelik Mustafa Yilmaz Mehmet Cagri Goktekin Mehtap Gurger Nevin Ilhan 《The American journal of emergency medicine》2017,35(12):1895-1898
Objective
We aimed to determine the levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in patients admitted to the emergency department with impaired consciousness due to metabolic or neurological reasons.Materials – methods
The study included 80 patients with ischemic stroke (IS), 40 patients with intracranial hemorrhage (ICH), 80 patients with metabolic disorder induced impaired consciousness (MDIC) and 40 healthy controls.Results
The levels of UCH-L1 [median (IQR)] were as follows: 5.59 ng/mL (3.90–9.37) in IS, 5.44 ng/ml (4.01–13.98) in ICH, 3.34 ng/ml (2.29–5.88) in MDIC and 3.94 ng/ml (3.31–7.95) in healthy volunteers. Significantly higher levels were detected in IS and ICH than in MDIC and healthy volunteers. In ROC curve analysis, we detected 63.75% sensitivity and 62.5% specificity (AUC = 0.626, p < 0.0199, 95% CI: 0.533–0.713) with a cutoff value of 4.336 ng/ml for IS and 75% sensitivity and 55% specificity (AUC = 0.664, p < 0.0071, 95% CI: 0.549–0.766) with a cut-off value of 4.036 ng/ml for ICH. However, the sensitivity and specificity for MDIC was 36.25% and 77.5%, respectively, with a cut-off value of 3.256 ng/ml (AUC = 0.525, p = 0.6521, 95% CI: 0.432–0.617). UCH-L1 levels were found to increase significantly with increasing time between the onset of symptoms and blood sampling (r = 0.345, p < 0.001). However, no correlation was found between UCH-L1 levels and age (r = 0.014, p = 0.833), GCS (r = ? 0.115, p = 0.074), mRS (r = 0.063, p = 0.475) and NIHSS (r = 0.056, p = 0.520).Conclusion
In this study, we detected significantly higher levels of UCH-L1 in patients with IS and ICH compared to patients with MDIC and healthy volunteers. 相似文献18.
Cakir M Mahsereci E Altunbas H Karayalcin U 《Journal of the National Medical Association》2005,97(5):732-734
Rhabdomyolysis is found to be associated with trauma; alcohol; drugs; viral infections, such as HIV, Epstein-Barr virus, cytomegalovirus and influenza; metabolic disorders; dermatomyositis; polymyositis; and hypothyroidism. Few cases of rhabdomyolysis associated with thyrotoxicosis have been reported. A patient who presented with delirium to the emergency department and was diagnosed with thyrotoxicosis and rhabdomyolysis is hereby presented. 相似文献
19.
Melahat
ütcen-Toller DDS MSc PhD Mehtap Keskin DDS PhD 《Journal of oral and maxillofacial surgery》2000,58(12):1381-1386
PURPOSE: In this study, the development of human embryonic temporomandibular joint (TMJ) and masticatory muscles were investigated by using computed 3-dimensional reconstructions. MATERIALS AND METHODS: Sixteen human embryos and fetuses, ranging from 6.5 to 107 mm crown-rump length, were examined. RESULTS: At 10 weeks, a band of mesenchyme extending from the attachment of the lateral pterygoid muscle to the condylar process was observed to pass through the medial side of the condylar process to attach to the malleus. The temporal, masseter, and pterygoid muscles develop from the so called "temporal muscle" primordium, and the temporal muscle was in continuity with the masseter muscle until 14 weeks of fetal life. CONCLUSIONS: The study shows that the muscles of mastication arise from a single primordium. It also confirms the presence of a ligamentous attachment between the lateral pterygoid muscle and the malleus. 相似文献
20.