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排序方式: 共有562条查询结果,搜索用时 15 毫秒
101.
102.
Safety of outpatient peripheral angioplasty 总被引:2,自引:0,他引:2
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Summary— Beta-adrenergic receptors (β/-AR) belong to the large multigenic family of receptors coupled to GTP-binding proteins. Three subtypes have been identified: β1 -, β2 - and β3 -AR. Much of the work delineating the precise pharmacological comparison of the three β-ARs has come from investigations with stably transfected Chinese hamster ovary cells (CHO cells). This review discusses the structure and function of β3 -AR in various species and presents new findings on a number of β3 -AR ligands including carazolol, tertatolol and CL 316,243 which were found to be selective and potent β3 -AR agonists and ZD 2079 and salmeterol which appear to display full but non-subtype selective agonistic activity. Species-related variations of the β3 -AR pharmacology have been shown for propranolol and bupranolol. With the ongoing characterization of the β3 -AR at the molecular and cellular level, and with the advent of computer-assisted molecular modelling to aid in the determination of the three-dimensional structure of the receptor, it is thought that novel β3 -AR compounds will become available with improved selectivity and potency. 相似文献
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IM Balfour-Lynn B Valman M Silverman AD Webster 《Archives of disease in childhood》1993,68(4):472-476
It is unknown why some infants wheeze during upper respiratory tract infections. One possibility is that secretory IgA, which has a major role in mucosal defence against viral infection, might be deficient in wheezy infants. The nasal IgA response to upper respiratory tract infection in 32 wheezy infants (median age 5.8 months) was compared with nine siblings (median age 2.6 years) who had nasal symptoms only. Nasal lavage was performed during infections and on follow up when free from symptoms, using inulin as a marker of dilution to determine absolute concentrations of IgA in the nasal secretions. The two groups showed a similar increase in total IgA and total protein levels during infection, but secretory IgA concentrations were unchanged. This study shows that wheezy infants have a normal nasal IgA response to infection and that the increase in total IgA during early infection is due to plasma exudation rather than increased production of secretory IgA. 相似文献
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Differential interleukin-1 elaboration by density-defined human monocyte subpopulations 总被引:1,自引:0,他引:1
Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1. 相似文献
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采用RITQ综合评定婴儿气质的报告 总被引:2,自引:0,他引:2
张琪 《中国心理卫生杂志》1997,11(3):155-157
采用Carey的RITQ为4-8个月婴儿气质的测查工具,结合专人问卷与观察,对400名婴儿的气质进行了综合评定,结果表明:九个气质因子的重测信度为0.77-0.90,多数气质因子间存在着显著的相关,相关系数为0.10-0.59。大、小婴儿活动水平、接近-退缩、适应及反应强度四个气质因子存在差异。气质类型与国外同龄婴儿及国内学前儿童的分布相接近。提示采用RITQ综合评定婴儿气质的信度和效度较好,可用于我国婴儿的气质测查及研究。 相似文献