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111.
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Emmanuelle Duceppe Salim Yusuf Vikas Tandon Reitze Rodseth Bruce M. Biccard Denis Xavier Wojciech Szczeklik Christian S. Meyhoff Maria Grazia Franzosi Jessica Vincent Sadeesh K. Srinathan Joel Parlow Patrick Magloire John Neary Mangala Rao Navneet K. Chaudhry Bongani Mayosi Miriam de Nadal P.J. Devereaux 《The Canadian journal of cardiology》2018,34(3):295-302
Background
Worldwide approximately 200 million adults undergo major surgery annually, of whom 8 million are estimated to suffer a myocardial injury after noncardiac surgery (MINS). There is currently no trial data informing the management of MINS. Antithrombotic agents such as direct oral anticoagulants might prevent major vascular complications in patients with MINS.Methods
The Management of Myocardial Injury After Noncardiac Surgery (MANAGE) trial is a large international blinded randomized controlled trial of dabigatran vs placebo in patients who suffered MINS. We used a partial factorial design to also determine the effect of omeprazole vs placebo in reducing upper gastrointestinal bleeding and complications. Both study drugs were initiated in eligible patients within 35 days of suffering MINS and continued for a maximum of 2 years. The primary outcome is a composite of major vascular complications for the dabigatran trial and a composite of upper gastrointestinal complications for the omeprazole trial. We present the rationale and design of the trial and baseline characteristics of enrolled patients.Results
The trial randomized 1754 patients between January 2013 and July 2017. Patients' mean age was 69.9 years, 51.1% were male, 14.3% had a history of peripheral artery disease, 6.6% had a history of stroke or transient ischemic attack, 12.9% had a previous myocardial infarction, and 26.0% had diabetes. The diagnosis of MINS was on the basis of an isolated ischemic troponin elevation in 80.4% of participants.Conclusion
MANAGE is the first randomized controlled trial to evaluate a potential treatment of patients who suffered MINS. 相似文献115.
Gastric function was assessed in Wistar rats which received propantheline bromide by daily injection for 20 weeks. The results were compared with those from two control groups, one of which was injected daily with saline for 20 weeks. Gastric acid secretion, as measured by test meal and after ligation of the pylorus, was similar in all three groups. Acid secretion, as measured by test meal with pentagastrin 100 µg/kg body weight, gastric emptying, and fundic mucosal volume, expressed in terms of body weight, were all significantly increased in rats given propantheline. Only those measurements of acid secretion obtained by test meal with pentagastrin showed a significant correlation with fundic mucosal volume. Hence, since this method provides the most accurate indication of secretory capacity, it is concluded that the prolonged parenteral administration of propantheline may lead to an increase in parietal cell mass and its correlate, maximal secretory capacity. The mechanism by which these changes are produced is obscure.The author is grateful to Mr. Howard Ireson for his expert technical assistance, and to Mr. Ralph Marshall, Department of Medical Illustration, Cardiff Royal Infirmary, for the photography employed.Propantheline bromide (Pro-Banthine) was generously supplied by G. D. Searle and Co., Ltd. 相似文献
116.
Osteomyelitis (bone infection) and neuro-osteoarthropathy (Charcot arthropathy) are limb-threatening complications of diabetic
neuropathy with very different therapies. Distinguishing between them may be difficult, but it is important. In Charcot arthropathy,
noninfectious soft tissue inflammation accompanies rapidly progressive destruction, first of joints, then of bone. This occurs
in a well-vascularized and severely neuropathic, but nonulcerated, foot. In osteomyelitis, chronic soft tissue ulceration
precedes infection of bone, which may be physically exposed. Magnetic resonance imaging and bone biopsy are the preferred
diagnostic tests, provided adequate technical and interpretive skills are available. 相似文献
117.
Dr. Ramanathan Visvanathan BM BCH FRCS FWACS FICS 《Digestive diseases and sciences》1992,37(10):1600-1605
H+ secretion was studied in guinea pig fundic mucosa incubated in (A) bicarbonate-Ringer's gassed with 95% O2-5% CO2, or (B) HEPES gassed with 100% O2 before and after luminal pH was lowered to 2.0 for periods up to 90 min. At pH 2.0 for 60 min, H+ secretion in group A tissues fell by 35±4% (P=0.02) from a control rate of 1.35±0.09 eq/cm2/hr and in group B tissues by 50±11% (P=0.01) from a control rate of 1.59±0.08 eq/cm2/hr. After 90 min at pH 2.0, H+ secretion in group A fell by 53±8% (P=0.02) from a control rate of 1.47±0.07 eq/cm2/hr and in group B fell by 44±6% (P=0.01) from a control rate of 1.38±0.07 eq/cm2/hr. Histamine 1×10–4 M stimulation following exposure to pH 2.0 for 90 min increased secretion in group A tissues from 0.80 ±0.14 to 1.06±0.13 eq/cm2/hr (P<0.05), compared with an increase in nonacidified controls from 1.15±0.22 to 1.80±0.20 eq/cm2/hr (P<0.05) and in group B tissues from 1.27±0.10 to 1.56±0.19 eq/cm2/hr (P<0.05) compared with nonacidified controls from 1.43±0.22 to 2.23±0.41 eq/cm2/hr (P<0.05). Secretory function and electrical characteristics were adversely affected by luminal acidification to pH 2.0 and suggested a breach in the mucosal barrier with damage to parietal cells.This study was funded by the National Institute of Health Grant No. AM 15681. 相似文献
118.
Remnant Lipoprotein Cholesterol and Mortality After Acute Myocardial Infarction: Further Evidence for a Hypercholesterolemia Paradox From the TRIUMPH Registry
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Seth S. Martin MD MHS Kamil F. Faridi MD Parag H. Joshi MD MHS Michael J. Blaha MD MPH Krishnaji R. Kulkarni PhD Arif A. Khokhar BM BCh MA Thomas M. Maddox MD Edward P. Havranek MD Peter P. Toth MD PhD Fengming Tang MS John A. Spertus MD MPH Steven R. Jones MD 《Clinical cardiology》2015,38(11):660-667
119.
120.
Using workload measurement tools in diverse care contexts: the experience of staff in mental health and learning disability inpatient settings
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