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21.
22.
Fabrizio Romano Marco Chiarelli Mattia Garancini Mauro Scotti Mauro Zago Gerardo Cioffi Matilde De Simone Ugo Cioffi 《World journal of gastroenterology : WJG》2021,27(21):2784-2794
According to Barcelona Clinic Liver Cancer recommendations, intermediate stage hepatocellular carcinomas (stage B) are excluded from liver resection and are referred to palliative treatment. Moreover, Child-Pugh B patients are not usually candidates for liver resection. However, many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection, maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver function. Several studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification, and this treatment gives good results in the setting of multinodular, large tumors in patients with portal hypertension and/or Child-Pugh B cirrhosis. In this review we explore this controversial topic, and we show through the literature analysis how liver resection may improve the short- and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma patients. However, other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection. 相似文献
23.
Pietro Palmisano MD Matteo Ziacchi MD Ernesto Ammendola MD Antonio D'Onofrio MD Gabriele Dell'Era MD Mattia Laffi MD Mauro Biffi MD Gerardo Nigro MD PhD Walter Bianchi MD Eleonora Prenna MD Andrea Angeletti MD Alessandro Guido MD Giulia Stronati MD Germano Gaggioli MD Antonio Dello Russo MD Michele Accogli MD Federico Guerra MD Italian Association of Arrhythmology Cardiac Pacing 《Journal of cardiovascular electrophysiology》2021,32(6):1712-1723
24.
G. De Mattia M. C. Bravi O. Laurenti M. Cassone-Faldetta A. Proietti O. De Luca A. Armiento C. Ferri 《Diabetologia》1998,41(11):1392-1396
Summary To assess in vivo effects of antioxidants on vascular cell adhesion molecule (VCAM)-1 expression, circulating soluble VCAM-1
and intraerythrocytic reduced glutathione (GSH) and GSH disulphide (GSSG) concentrations were evaluated in non-insulin-dependent
diabetic patients without complications (9 men, 6 women, 48 ± 6 years old) before and after 1 month of either oral N-acetyl-L-cysteine (1.200 mg/day) or placebo treatments, given in randomized, cross-over, double-blind fashion. Ten healthy
subjects (7 men, 3 women, 52 ± 4 years old) served as control subjects. Baseline plasma VCAM-1 concentrations were higher
(p = 0.007) in non-insulin-dependent diabetic patients (707.9 ± 52.5 ng/ml) than in control subjects (627.3 ± 84.6 ng/ml). Intraerythrocytic
GSSG content was higher (non-insulin dependent diabetic patients: 0.618 ± 0.185 μmol/g Hb; control subjects: 0.352 ± 0.04
μmol/g Hb, p = 0.0002), whereas intraerythrocytic GSH concentrations were lower (p = 0.001) in non-insulin dependent diabetic patients (6.0 ± 0.7 μmol/g Hb) than in control subjects (7.1 ± 0.5 μmol/g Hb).
The mean GSH:GSSG ratio was also lower (p = 0.0001) in the first (10.9 ± 4.5) than in the second group (20.2 ± 1.4). Circulating VCAM-1 and intraerythrocytic GSH concentrations
were negatively correlated in non-insulin diabetic patients (r = 0.605, p = 0.01). Treatment with N-acetyl-L-cysteine decreased plasma VCAM-1 (p = 0.01) and intraerythrocytic GSSG (p = 0.006) but increased GSH concentrations (p = 0.04) and the GSH:GSSG ratio (p = 0.004) in non-insulin dependent diabetic patients. Our data indicate that the vascular endothelium is activated in non-insulin
dependent diabetes. Antioxidant treatment counterbalanced such endothelial activation. Thus, antioxidant agents might protect
against oxidant-related upregulation of endothelial adhesion molecules and slow down the progression of vascular damage in
non-insulin dependent diabetes. [Diabetologia (1998) 41: 1392–1396]
Received: 15 May 1998 and in revised form: 8 July 1998 相似文献
25.
Carmen Barba Massimo Cossu Renzo Guerrini Giancarlo Di Gennaro Flavio Villani Luca De Palma Laura Grisotto Alessandro Consales Domenica Battaglia Nelia Zamponi Piergiorgio dOrio Martina Revay Michele Rizzi Sara Casciato Vincenzo Esposito Pier Paolo Quarato Roberta Di Giacomo Giuseppe Didato Chiara Pastori Giusy Carfi Pavia Simona Pellacani Giulia Matta Mattia Pacetti Gianpiero Tamburrini Elisabetta Cesaroni Gabriella Colicchio Giampaolo Vatti Sofia Asioli Massimo Caulo Carlo Efisio Marras Laura Tassi 《Epilepsia》2021,62(1):128-142
26.
Baldassarre Martire Antonia Gentile Ruggiero Francavilla Attilio De Santis Domenico De Mattia 《Immunopharmacology and immunotoxicology》2013,35(4):535-543
Common variable immunodeficiency (CVID) is the commonest primary immunodeficiency disease characterized by defective antibody production and various degrees of T cell numbers abnormality or impaired proliferation to mitogens. Clinical features include recurrent bacterial sinopulmonary and gastrointestinal infections. Autoimmunity is very common in CVID, occurring in approximately 25% of the patients particularly with autoimmune thrombocytopenia, hemolytic anemia, inflammatory bowel disease, and rheumatoid arthritis. Persistent antigen stimulation, secondary to a defective eradication of pathogens followed by a compensatory exaggerated chronic inflammatory response, is the primary cause leading to autoimmunity. Here we describe a girl with CVID in whom a chronic liver disease mimicking autoimmune hepatitis developed after hepatitis C virus infection. The immunosuppressive treatment with cyclosporine A proved effective in reversing liver disease. 相似文献
27.
Norma Maugeri Mattia Baldini Patrizia Rovere-Querini Attilio Maseri Maria Grazia Sabbadini 《Autoimmunity》2013,46(4):386-388
Ischemia is a leading causes of morbidity in giant cell arteritis (GCA). We studied circulating platelets and leukocytes in patients with GCA and with polymyalgia rheumatica. Normal healthy donors (>60 a) served as controls. Patients had a significantly greater fraction of platelets expressing P-selectin, of platelet–Nph and platelet–Mo aggregates, and of Nph and Mo expressing tissue factor. These differences were correlated with the percentage of platelets expressing P-selectin and were not influenced by clinical features or by systemic inflammation. Activated circulating leukocytes and platelets could contribute to indolent vessel inflammation and possibly to thromboembolic events in patients with systemic large vessel vasculitis. 相似文献
28.
Rigoli Mattia Facchin Alessio Cardile Davide Beschin Nicoletta Luzzatti Claudio 《Neurological sciences》2021,42(6):2461-2469
Neurological Sciences - The speed of information processing is one of the most reliable indices of cognitive efficiency. The most common way to evaluate this ability is to assess reaction times... 相似文献
29.
Farina Roberto Simonelli Anna Baraldi Andrea Pramstraller Mattia Minenna Luigi Toselli Luca Maietti Elisa Trombelli Leonardo 《Clinical oral investigations》2021,25(10):5897-5906
Clinical Oral Investigations - To evaluate yearly tooth loss rate (TLR) in periodontitis patients with different periodontal risk levels who had complied or not complied with supportive periodontal... 相似文献
30.
Elisa Maria Fiorelli Tiziana Carandini Delia Gagliardi Viviana Bozzano Mattia Bonzi Eleonora Tobaldini Giacomo Pietro Comi Elio Angelo Scarpini Nicola Montano Monica Solbiati 《Internal and emergency medicine》2018,13(8):1287-1303
The aim of our study is to compare patent foramen ovale (PFO) closure versus medical treatment and antiplatelet versus anticoagulant therapy in patients with cryptogenic stroke (CS) and PFO. We conducted a systematic review and meta-analysis with trial sequential analysis (TSA) of randomized trials. Primary outcomes are stroke or transient ischemic attack (TIA) and all-cause mortality. Secondary outcomes are peripheral embolism, bleeding, serious adverse events, myocardial infarction and atrial dysrhythmias. We performed an intention to treat meta-analysis with a random-effects model. We include six trials (3677 patients, mean age 47.3 years, 55.8% men). PFO closure is associated with a lower recurrence of stroke or TIA at a mean follow-up of 3.88 years compared to medical therapy [risk ratio (RR) 0.55, 95% CI 0.38–0.81; I2?=?40%]. The TSA confirms this result. No difference is found in mortality (RR 0.74, 95% CI 0.35–1.60; I2?=?0%), while PFO closure is associated with a higher incidence of atrial dysrhythmias (RR 4.55, 95% CI 2.16–9.60; I2?=?25%). The rate of the other outcomes is not different among the two groups. The comparison between anticoagulant and antiplatelet therapy shows no difference in terms of stroke recurrence, mortality and bleeding. There is conclusive evidence that PFO closure reduces the recurrence of stroke or TIA in patients younger than 60 years of age with CS. More data are warranted to assess the consequences of the increase in atrial dysrhythmias and the advantage of PFO closure over anticoagulants. 相似文献