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排序方式: 共有9170条查询结果,搜索用时 15 毫秒
991.
N Pellegrini P Laforet D Orlikowski M Pellegrini C Caillaud B Eymard J-C Raphael F Lofaso 《The European respiratory journal》2005,26(6):1024-1031
The objective of the present study was to prospectively evaluate relationships linking age, respiratory function and locomotor function in 29 outpatients with late-onset Pompe's disease and to retrospectively determine clinical outcomes. Using univariate regression analysis, vital capacity (VC) was weakly, but significantly, correlated to shoulder motility, Walton score and lower-limb Modified Medical Research Council score. Six patients were able to walk without a walking aid and with only the help of a handrail on the stairs (Walton score=3), although VC was <50%. No parameters were significantly correlated with age. As assessed retrospectively, VC and locomotion deteriorated over time in most patients. In contrast, among the 16 patients started on invasive or noninvasive ventilation with VC monitoring, eight had a VC increase at the first measurement time-point. The absence of correlation with age and the presence, in some patients, of severe respiratory insufficiency without severe limb girdle muscle weakness indicate that respiratory function should be monitored independently from the degree of peripheral muscle weakness. Mechanical ventilation and tracheostomy may improve vital capacity and should, therefore, be taken into account when evaluating treatments for the adult form of Pompe's disease. 相似文献
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Clinical and angiographic outcome after sirolimus-eluting stent implantation in aorto-ostial lesions. 总被引:4,自引:0,他引:4
Ioannis Iakovou Lei Ge Iassen Michev Giuseppe M Sangiorgi Matteo Montorfano Flavio Airoldi Alaide Chieffo Goran Stankovic Giancarlo Vitrella Mauro Carlino Nicola Corvaja Carlo Briguori Antonio Colombo 《Journal of the American College of Cardiology》2004,44(5):967-971
OBJECTIVES: This observational study evaluated the clinical and angiographic outcomes of patients with aorto-ostial coronary artery disease treated with sirolimus-eluting stents (SESs) or with bare metal stents (BMSs). BACKGROUND: The safety and effectiveness of SESs for the treatment of aorto-ostial lesions have not been demonstrated. METHODS: We identified 82 consecutive patients who underwent percutaneous coronary interventions in 82 aorto-ostial lesions using the SES (32 patients) or BMS (50 patients) and compared the two groups of patients. The incidence of major adverse cardiac events (MACE), including death or Q-wave myocardial infarction (MI), target lesion revascularization (TLR), and target vessel revascularization (TVR), were recorded in-hospital and at a 10-month follow-up. RESULTS: All stents were implanted successfully. There were no statistically significant differences regarding major in-hospital complications between the two groups. At 10-month follow-up, two (6.3%) patients in the SES group and 14 (28%) patients in the BMS group underwent TLR (p = 0.01); MACE were less frequent in the SES group compared to the BMS group (19% vs. 44%, p = 0.02). Angiographic follow-up showed lower binary restenosis rates (11% vs. 51%, p = 0.001) and smaller late loss (0.21 +/- 0.31 mm vs. 2.06 +/- 1.37 mm, p < 0.0001) in the SES group. CONCLUSIONS: The main finding of our study is that, compared to the BMS, implantation of the SES in aorto-ostial lesions appears safe and effective, with no increase in major in-hospital complications and a significant improvement in restenosis and late event rates at 10-month follow-up. 相似文献
995.
Ablation with an internally irrigated radiofrequency catheter: Learning how to avoid steam pops 总被引:1,自引:0,他引:1
Joshua M. Cooper MD John L. Sapp MD Usha Tedrow MD Christine P. Pellegrini RN MSN David Robinson BS Laurence M. Epstein MD William G. Stevenson MD 《Heart rhythm》2004,1(3):193-333
OBJECTIVES: The aim of this study was to assess the feasibility of using electrode temperature, impedance, and power to predict and thereby potentially prevent steam pops during cooled radiofrequency (RF) ablation. BACKGROUND: When myocardial temperature reaches 100 degrees C during RF catheter ablation, steam explosions are seen. Saline-cooled RF ablation reduces temperatures at the electrode-tissue interface, but excessive intramyocardial heating still may occur. METHODS: In anesthetized swine, 26 cooled RF applications were made in the right and left atria while observing with intracardiac echocardiography (ICE). Power delivery was increased gradually until a steam explosion was seen or a maximum output of 50 W was reached. RESULTS: ICE identified steam explosions in 21 RF applications. Steam explosions were associated with a large impedance increase, >25 Omega in only three cases, whereas small increases <10 Omega (mean 5.3 +/- 2.6 Omega) occurred in 18 cases. Mean electrode temperature at the time of steam explosion was 43.6 degrees C +/- 5.3; 18 of 21 explosions occurred when temperature reached >/=40 degrees C. Mean power and impedance drop were similar for applications with and without steam explosions. Five steam explosions were associated with a sudden drop in electrode temperature. CONCLUSIONS: Steam explosions are common when cooled electrode temperature exceeds 40 degrees C and are not predictable from power or impedance drop. Small impedance rises and sudden drops in measured electrode temperature indicate possible steam formation. Maintaining cooled electrode temperature <40 degrees C during RF likely will reduce the risk of steam explosions. 相似文献
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A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity 下载免费PDF全文
998.
999.
Gregorio Di Franco Enrico Tagliaferri Erica Pieroni Edoardo Benedetti Simone Guadagni Matteo Palmeri Niccolò Furbetta Daniela Campani Giulio Di Candio Mario Petrini Franco Mosca Luca Morelli 《Infection》2018,46(3):317-324
Purpose
Invasive aspergillosis (IA) represents a major cause of morbidity and mortality in immunocompromised patients. Involvement of the gastrointestinal tract by Aspergillus is mostly reported as part of a disseminated infection from a primary pulmonary site and only rarely as an isolated organ infection.Methods
We report a case of small bowel perforation due to IA in a patient with acute leukemia under chemotherapy and pulmonary aspergillosis. We performed a systematic review of the literature as well.Results
A 43-year-old man with acute myeloid leukemia under chemotherapy developed severe neutropenia and pulmonary aspergillosis due to Aspergillus flavus. He developed melena and hemodynamic failure and a contrast-enhanced ultrasound scan suggested active intestinal bleeding. During emergency laparotomy we found multiple intestinal abscesses, several perforations of intestinal loop and Aspergillus flavus was isolated from the abscesses. Resection of the jejunum was performed. The patient received voriconazole and finally recovered. The patient is now alive and in complete disease remission. From literature review we found 35 intestinal IA previously published in single case reports or small case series as well.Conclusion
Clinical manifestations of gastrointestinal aspergillosis are nonspecific, such as abdominal pain, and only occasionally it presents as an acute abdomen. Antemortem detection of bowel involvement is rarely achieved and, only in cases of complicated gastrointestinal aspergillosis, the diagnosis is achieved thanks to the findings during surgery. Gastrointestinal aspergillosis should be suspected in patients with severe and prolonged neutropenia with or without pulmonary involvement in order to consider the right therapy and prompt surgery.1000.
Romano F Piacentini MG Franciosi C Caprotti R De Fina S Cesana G Uggeri F Conti M Uggeri F 《Hepato-gastroenterology》2004,51(60):1872-1876
BACKGROUND/AIMS: Surgery has appeared to induce lymphocytopenia and this decrease in host defenses during postoperative period could promote both the proliferation of possible micrometastases and the implantation of surgically disseminated tumor cells. The aim of this study is to evaluate if the preoperative subcutaneous injection of IL-2 (interleukin-2) may be able to abrogate surgery-induced immunosuppression in radically operable gastric cancer and to assess its toxicity. METHODOLOGY: This phase II study included 39 consecutive patients with histologically proven gastric adenocarcinoma (M/F 26/13; mean age 68; range 48-82) who underwent radical surgery from October 1999 to December 2000. Patients were randomized to be treated with surgery alone as controls (20 patients) or surgery plus preoperative treatment with recombinant human IL-2 (19 patients). IL-2 was administered subcutaneously, at a dose of 9,000,000 IU, for three consecutive days, followed by surgery within 36 hours from IL-2 withdrawal. We considered the total lymphocyte count and lymphocyte subset (CD4, CD4/CD8) during the preoperative period, before IL-2 administration, and on the 14th and 50th day. RESULTS: Two groups were well matched for type of surgery and extent of disease. All the patients underwent radical surgery plus D2 lymphadenectomy. At baseline, there were no significant differences in total lymphocyte and lymphocyte subsets between groups. The control group showed a significant decrease of total lymphocytes, CD4 cells, and CD4/CD8 ratio at the 14th postoperative day relative to the baseline value. Among the 22 patients evaluated in the control group 13 had a decreased of CD4 under 500 cells/mm3 (65%). Instead in the IL-2 group a significant increase was observed over the control group values of total lymphocytes and CD4 cells (14th ly total and CD4: IL-2 vs. control p<0.05). Moreover in this group only 3 patients had CD4 under 500 cells/mm3 (15%). This difference in CD4 count, is significant at the 50th postoperative day too (p=0.006). No anesthesiologic or surgical complication was seen in IL-2 treated group, with low grade of toxicity (WHO grade:1): the main effect was fever (14/19) easily manageable, with no cardiovascular complications. Furthermore, IL-2 group showed lower postoperative complications (p<0.05) and higher lymphocyte/eosinophil infiltration into the tumor (p<0.002). CONCLUSIONS: This phase II study would suggest that a preoperative immunotherapy with IL-2 is a well tolerated treatment able to prevent surgery induced lymphocytopenia. IL-2 seems to neutralize the immunosuppression induced by operation and so to stimulate the host reaction against tumor tissue (lymphocytes/eosinophils infiltration). Next randomized clinical trials could investigate the prognostic impact of IL-2 on the clinical course. 相似文献