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排序方式: 共有5050条查询结果,搜索用时 8 毫秒
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Naga Venkata K. Pothineni MD Nigel Amankwah MD Pasquale Santangeli MD PhD Robert D. Schaller DO Gregory E. Supple MD Rajat Deo MD Saman Nazarian MD Fermin C. Garcia MD Sanjay Dixit MD David J. Callans MD Francis E. Marchlinski MD David S. Frankel MD 《Journal of cardiovascular electrophysiology》2021,32(2):345-353
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Amrish Deshmukh MD John Larson MD Michael Ghannam MD Mohammed Saeed MD Ryan Cunnane MD Hamid Ghanbari MD Rakesh Latchamsetty MD Thomas Crawford MD Krit Jongnarangsin MD Frank Pelosi Jr. MD Aman Chugh MD Hakan Oral MD Fred Morady MD Frank Bogun MD Jackson J. Liang DO 《Journal of cardiovascular electrophysiology》2021,32(12):3173-3178
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Greene CM Van Beneden CA Javadi M Skoff TH Beall B Facklam R Abercrombie DR Kramer SL Arnold KE 《American journal of infection control》2005,33(2):108-113
BACKGROUND: Invasive group A streptococcus (GAS) affects approximately 10,500 persons annually; 1 in 5 patients >/=65 years die. In August 2001, CDC investigated a cluster of GAS deaths in a Georgia long-term care facility (LTCF). METHODS: We screened LTCF residents and staff for GAS carriage and conducted a retrospective cohort study among residents. We defined a case as GAS isolation associated with clinical infection. RESULTS: Eight cases were identified (median age: 79 years); 6 (75%) patients died. Carriage was similar in residents (10%) and staff (9%). All isolates among residents and 63% among staff were type emm 77. Risk factors for GAS disease or carriage among residents were receiving skin treatment (relative risk [RR] = 4.0, 95% confidence interval [CI] = 1.9-11.0) and having an infected or colonized roommate (RR = 2.0, 95% CI = 1.10-5.0). No wound care nurse carried GAS. Interventions included education about standardized infection control guidelines and appropriate hand hygiene; carriers were treated with antibiotics. No subsequent GAS cases were identified in the following year. CONCLUSIONS: Transmission of GAS in this outbreak likely occurred during wound care and ended with improved hand hygiene. This investigation highlights additional research and policy needs for control of severe GAS infections among the high-risk LTCF population. 相似文献
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Abd El Kader Ait Tayeb Laurent Becquemont Khalil El‐Asmar Kaïna Mahmoudi Romain Colle Severine Trabado Florence Gressier Bruno Feve Emmanuelle Corruble Cline Verstuyft 《Basic & clinical pharmacology & toxicology》2020,126(3):289-295
Two thirds of patients suffering from a major depressive episode (MDE) do not reach a complete response with antidepressant drugs. This lack of response is due to several factors, including genetic determinants. Since major depressive disorder is associated with inflammatory and oxidative stress abnormalities, the metabolism of superoxide anions might be involved in non‐response to antidepressant drugs. Superoxide anions are metabolized by manganese‐dependent superoxide dismutase (SOD2) in the mitochondria. A functional genetic polymorphism (SOD2, rs4880), responsible of a 40% reduction in enzyme activity, is associated with anti‐inflammatory response of rosuvastatin. We investigated the association of ala‐allele of SOD2 rs4880 and both antidepressant efficacy and inflammatory parameters in patients treated for a MDE with antidepressant drugs. The Hamilton Depression Rating Scale (HDRS) score and levels of plasma CRP and inflammatory cytokines were assessed at baseline, one month (M1), 3 months (M3) and 6 months (M6) after antidepressant treatment. They were compared according to SOD2 genetic polymorphism. Of the 484 patients studied, 361 (74.6%) carried the ala‐allele (Ala group), 123 (25.4%) of them had Val/Val genotype (Val/Val group). No significant difference was observed between the Ala and Val/Val groups neither for baseline clinical characteristics, nor for HDRS scores, response/remission rates, plasma CRP and cytokine levels throughout the study. The rs4880 SOD2 genetic polymorphism was not associated with the clinical response and cytokines levels after antidepressant treatment. These data suggest that SOD2 is not a major genetic determinant of antidepressant response. Other genes of the oxidative stress pathways should be explored in further studies. 相似文献