全文获取类型
收费全文 | 11729篇 |
免费 | 623篇 |
国内免费 | 85篇 |
专业分类
耳鼻咽喉 | 64篇 |
儿科学 | 168篇 |
妇产科学 | 77篇 |
基础医学 | 1430篇 |
口腔科学 | 239篇 |
临床医学 | 704篇 |
内科学 | 2924篇 |
皮肤病学 | 236篇 |
神经病学 | 944篇 |
特种医学 | 704篇 |
外科学 | 2087篇 |
综合类 | 42篇 |
预防医学 | 379篇 |
眼科学 | 186篇 |
药学 | 763篇 |
中国医学 | 45篇 |
肿瘤学 | 1445篇 |
出版年
2023年 | 71篇 |
2022年 | 141篇 |
2021年 | 334篇 |
2020年 | 165篇 |
2019年 | 234篇 |
2018年 | 263篇 |
2017年 | 253篇 |
2016年 | 298篇 |
2015年 | 314篇 |
2014年 | 417篇 |
2013年 | 485篇 |
2012年 | 736篇 |
2011年 | 839篇 |
2010年 | 485篇 |
2009年 | 406篇 |
2008年 | 675篇 |
2007年 | 741篇 |
2006年 | 745篇 |
2005年 | 805篇 |
2004年 | 743篇 |
2003年 | 717篇 |
2002年 | 756篇 |
2001年 | 130篇 |
2000年 | 97篇 |
1999年 | 136篇 |
1998年 | 200篇 |
1997年 | 145篇 |
1996年 | 160篇 |
1995年 | 131篇 |
1994年 | 115篇 |
1993年 | 109篇 |
1992年 | 92篇 |
1991年 | 60篇 |
1990年 | 58篇 |
1989年 | 51篇 |
1988年 | 33篇 |
1987年 | 34篇 |
1986年 | 27篇 |
1985年 | 25篇 |
1984年 | 23篇 |
1983年 | 18篇 |
1982年 | 28篇 |
1981年 | 18篇 |
1980年 | 18篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1975年 | 9篇 |
1974年 | 13篇 |
1973年 | 10篇 |
1969年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Yuichi Miyazaki Kazunori Toyoda Yasuyuki Iguchi Teruyuki Hirano Norifumi Metoki Masanori Tomoda Masayuki Shiozawa Junpei Koge Yasushi Okada Yuka Terasawa Muneaki Kikuno Haruko Okano Joji Hagii Masanori Nakajima Teppei Komatsu Masahiro Yasaka 《Journal of atherosclerosis and thrombosis》2021,28(5):544
Aim: This study aimed to investigate the diagnostic yield of 7-day Holter monitoring for detecting covert atrial fibrillation (AF) in patients with recent embolic stroke of undetermined source (ESUS) and to identify the pre-entry screening biomarkers that had significant associations with later detection of AF (clinicaltrials.gov. ). Methods: A total of 206 patients who have recent ESUS without previously documented AF underwent Holter electrocardiography using a chest strap-style monitor. External validation of biomarkers predictive of AF was performed using 83 patients with ESUS who were implanted with insertable cardiac monitors. Results: The 7-day Holter monitoring started at a median of 13 days after the onset of stroke. AF was detected in 14 patients, and three of these showed a single AF episode lasting <2 min. The median time delay to the first documented AF was 50 h. Each of serum brain natriuretic peptide ≥ 66.0 pg/mL (adjusted odds ratio 5.23), atrial premature contractions (APCs) ≥ 345 beats (3.80), and APC short runs ≥ 13 (5.74) on 24-h Holter prior to the 7-day Holter showed a significant association with detection of AF, independent of age and physiological findings in this derivation cohort, and all of these showed a significant association in the validation cohort (adjusted odds ratio 6.59, 7.87, and 6.16, respectively). Conclusions: In recent ESUS patients, the detection rate of AF using the 7-day Holter monitoring was 6.8% (95% CI 4.1%–11.1%). Brain natriuretic peptide, APC count, and APC short runs in the standard clinical workup seemed to be predictors of covert AF. NCT02801708相似文献
992.
Masayuki Inoue Nayoung Lee Takeshi Tsumuraya Ikuo Fujii Masahiro Hirama 《Toxicon》2009,53(7-8):802-805
Ciguatera is a global food poisoning caused by the consumption of fish that have accumulated sodium channel activator toxins, ciguatoxins. At present, most diagnosed cases of ciguatera are treated with symptomatic and supportive remedies, and no specific therapy has been devised. Here we report that ciguatoxin CTX3C can be effectively neutralized in vitro and in vivo by simultaneous use of two anti-ciguatoxin monoclonal antibodies, providing the first rational approach toward directly preventing and treating ciguatera. 相似文献
993.
Hirohito MURAMATSU Daizo SAITO Shigeaki YOSHIDA Shichiroku WATANABE Narukazu BOKU Takahiro FUJII Mitsuya YOSHINO Hisao TAJIRI Hajime YAMAGUCHI Masayoshi YOSHIMORI Yanao OGURO Mitsuru SASAKO Taira KINOSHITA Keiichi MARUYAMA Masayuki ITABASHI Teruyuki HIROTA 《Digestive endoscopy》1991,3(3):357-367
Abstract: In this study the definition of cardiac cancer (histologically adenocarcinoma) was taken to be a cancerous lesion, the size of which is less than 4 cm and the center of which is located within 2 cm from the esophagocardiac junction. 42 patients (0.8%) fit the above definition of cardiac cancer out of 4,958 patients with solitary gastric cancer operated on at the National Cancer Center Hospital daring the period between 1962 and 1988. The clinicopathological and endoscopic findings of these 42 patients were compared with those of 132 patients with gastric cancer located in the upper third of the stomach other than in the cardia (cancer in the other C-area). In the group with cardiac cancer, the male patients (M/F ratio: 3.7), the elderly patients (mean age: 61.3 years), a differentiated type of adenocarcinoma (90%), lesions located at the lesser curvature (62%) and the elevated type of lesion were found to predominate. The incidence of early cancer (60%) and the incidence of small lesions less than 2 cm (32%) in diameter were lower than in the patients with cancers in the other C-area. In the group with cardiac cancer, however, the incidence of such types of early cancer as the depressed lesion, a small lesion less than 2 cm in diameter and lesions difficult to diagnose endoscopically, have been increasing. In recent years, cardicac cancers have been found not only on the lesser curvature, but also in different areas of the cardia. These results suggest an improvement in endoscopic diagnosis for cardiac cancer. To make early detection more precise, it will be indispensable not to overlook even faint or indistinct mucosal abnormalities at the area adjacent to the esophagocardiac junction. 相似文献
994.
Takeshi Hisa Masaki Tanaka Hiroki Ohkubo Masayuki Furutake Masato Takamatsu 《Digestive endoscopy》2008,20(1):44-47
A 56‐year‐old man was referred for an enlarging pancreatic pseudocyst that developed after severe acute pancreatitis with gallstones. Abdominal ultrasound showed a huge cystic lesion with a large amount of solid high echoic components. Arterial phase contrast‐enhanced computed tomography scan revealed arteries across the cystic cavity. Stents were placed after endoscopic ultrasound‐guided cystgastrostomy; however, the stents were obstructed by necrotic debris, and secondary infection of the pseudocyst occurred. Therefore, the cystgastrostomy was dilated by a dilation balloon, and a forward‐viewing endoscope was inserted into the cystic cavity. Many vessels and a large amount of necrotic debris existed in the cavity. Under direct vision, all necrotic debris was safely removed using a retrieval net and forceps. One year after this procedure, there was no recurrence. Our case indicates that peripancreatic fat necrosis can cause exposure of vessels across/along the cystic cavity, and blind necrosectomy should be avoided. 相似文献
995.
996.
Kazuyoshi Aoyama Youichi Kondou Yasuyuki Suzuki Hirokazu Sakai Masayuki Oshima Eiichi Inada 《Journal of anesthesia》2010,24(4):633-638
Aggressive posterior retinopathy of prematurity (ROP) can, if left untreated, rapidly progress to total retinal detachment
within 1–2 weeks. Early surgical intervention with vitrectomy has been attempted to treat and prevent further retinal detachment.
We investigated the anesthetic management of 29 infants with aggressive posterior ROP undergoing early vitrectomy. Postmenstrual
age at surgery ranged from 35 to 47 weeks (median 41). Weight ranged from 1408 to 3478 g (median 1875). All infants underwent
general anesthesia with fentanyl and sevoflurane. Mean surgical and anesthetic times were 88.6 and 143.6 min, respectively.
In two patients, vitrectomy was postponed for one week due to enteric perforation in one patient and meningitis in the other,
because the anticipated perioperative risk was deemed high. There were no intraoperative complications, except in one patient
who developed pulmonary edema following upper airway obstruction. All patients survived to be discharged from NICU or transferred
to the referring hospital. In all cases, complete or partial retinal reattachment was successfully achieved. Early vitrectomy
for aggressive posterior ROP may be effective despite associated perioperative risks. As this condition progresses rapidly,
prompt preoperative organization, including anesthetic planning, is important and useful. Anesthesiologists can play an important
role in the perioperative management of such high-risk infants. 相似文献
997.
998.
Piroxicam and Acarbose as Chemopreventive Agents for Spontaneous Intestinal Adenomas in APC Gene 1309 Knockout Mice 总被引:5,自引:0,他引:5
Carlos F. Quesada Hiroyuki Kimata Masayuki Mori Masahiko Nishimura Toshihiro Tsuneyoshi Shozo Baba 《Cancer science》1998,89(4):392-396
The use of nonsteroidal anti-inflammatory drugs has been suggested to have a chemopreventive effect against colon carcinoma, through the inhibition of cyclooxygenases 1 and 2, in patients with familial adenomatous polyposis and in animal models. Acarbose, an alpha-glycosidase inhibitor, may also be chemopreventive. In order to examine the effects of these drugs we employed APC gene knockout mice randomized into 3 groups, one for treatment with piroxicam (0.05% concentration in drinking water), one for acarbose (0.04% concentration in food) and another for the control. After 14 weeks of treatment, mice were killed for quantitation of gastric and intestinal adenomas. Tumor multiplicity in the whole gastrointestinal tract decreased from 33.89±13.07 tumors/mouse in the control group to 17.05±7 tumors/mouse in the piroxicam-treated group ( P <0.001). The decrease in the acarbose-treated group (29.68±12.86 tumors/mouse) was not significant ( P >0.05). The number of tumors ≥3 mm in diameter was also quantified in all gastrointestinal segments. The number of such tumors in the piroxicam group was decreased to 0.56±1.2 tumors/mouse from the control value of 3.78±1.17 tumors/mouse ( P <0.001), while in the acarbose-treated group the number decreased to 2.36±1.7 tumors/mouse ( P <0.01). Thus, piroxicam decreases the size and number of gastrointestinal adenomas in APC 1309 knockout mice, while acarbose decreases only the size. 相似文献
999.
Redox behavior of cytochrome oxidase and neurological prognosis in 66 patients who underwent thoracic aortic surgery. 总被引:1,自引:0,他引:1
Yasuyuki Kakihana Akira Matsunaga Kazumi Tobo Sumikazu Isowaki Masayuki Kawakami Isao Tsuneyoshi Yuichi Kanmura Mamoru Tamura 《European journal of cardio-thoracic surgery》2002,21(3):434-439
OBJECTIVE: Using near-infrared spectroscopy (NIRS), we have developed a new approach to the measurement of the redox state of cytochrome oxidase (cyt. ox.) in the brain. Our previous animal study showed that oxygen-dependent redox changes in cyt. ox. occur only when oxygen delivery is badly impaired. Therefore, in this study, we retrospectively examined the relationship between the redox behavior of cyt. ox. (measured by NIRS) during an operation and the neurological outcome in patients. METHODS: We studied 66 patients undergoing thoracic aortic surgery with cardiopulmonary bypass. Cerebral oxygenation was monitored by NIRS, and relative values for the concentrations of oxy-Hb, deoxy-Hb, and the redox state of cyt. ox. in the brain were calculated using our developed algorithm. RESULTS: Retrospective assessment revealed three different types of cyt. ox. behavior: (1) no change (type-A) in 34 cases (51.5%), (2) a temporary reduction, with a subsequent return to the pre-surgery baseline level (type-B) in 29 cases (43.9%), or (3) a marked and prolonged reduction (type-C) in only three cases (4.5%). Nine of the 66 patients (13.6%; one type-A, five type-B, and all three type-C patients) showed evidence of postoperative brain injury (in the type-A patient, the injury proved to be localized and far from the monitoring site). The relationship between the occurrence of such an injury and the type of cyt. ox. behavior seen during the operation was highly significant (P<0.0001; chi-square test for independence). CONCLUSIONS: Our data suggest that the redox behavior of cyt. ox. during an operation is a good (though not perfect) predictor of postoperative cerebral outcome, and that overall tissue oxygen sufficiency can be confirmed by near-infrared measurement of cyt. ox. 相似文献
1000.