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排序方式: 共有1015条查询结果,搜索用时 15 毫秒
41.
Takashi Ando Yuichi Riku Akio Akagi Hiroaki Miyahara Mitsuaki Hirano Toshimasa Ikeda Hiroyuki Yabata Ryuichi Koizumi Chisato Oba Saori Morozumi Keizo Yasui Atsuko Goto Taiji Katayama Satoko Sakakibara Ikuko Aiba Motoko Sakai Masaaki Konagaya Keiko Mori Yasuhiro Ito Hiroyuki Yuasa Masayo Nomura Kristine Joyce L. Porto Jun Mitsui Shoji Tsuji Maya Mimuro Yoshio Hashizume Masahisa Katsuno Yasushi Iwasaki Mari Yoshida 《Brain pathology (Zurich, Switzerland)》2022,32(1):e13002
The striatonigral and olivopontocerebellar systems are known to be vulnerable in multiple system atrophy (MSA), showing neuronal loss, astrogliosis, and alpha-synuclein-immunoreactive inclusions. MSA patients who displayed abundant neuronal cytoplasmic inclusions (NCIs) in the regions other than the striatonigral or olivopontocerebellar system have occasionally been diagnosed with variants of MSA. In this study, we report clinical and pathologic findings of MSA patients characterized by prominent pathologic involvement of the hippocampus. We assessed 146 consecutively autopsied MSA patients. Semi-quantitative analysis of anti-alpha-synuclein immunohistochemistry revealed that 12 of 146 patients (8.2%) had severe NCIs in two or more of the following areas: the hippocampal granule cells, cornu ammonis areas, parahippocampal gyrus, and amygdala. In contrast, the remaining 134 patients did not show severe NCIs in any of these regions. Patients with severe hippocampal involvement showed a higher representation of women (nine women/three men; Fisher's exact test, p = 0.0324), longer disease duration (13.1 ± 5.9 years; Mann–Whitney U-test, p = 0.000157), higher prevalence of cognitive impairment (four patients; Fisher's exact test, p = 0.0222), and lower brain weight (1070.3 ± 168.6 g; Mann–Whitney U-test, p = 0.00911) than other patients. The hippocampal granule cells and cornu ammonis area 1/subiculum almost always showed severe NCIs. The NCIs appeared to be ring-shaped or neurofibrillary tangle-like, fibrous configurations. Three of 12 patients also had dense, round-shaped NCIs that were morphologically similar to pick bodies. The patients with Pick body-like inclusions showed more severe atrophy of the medial temporal lobes and broader spreading of NCIs than those without. Immunohistochemistry for hyperphosphorylated tau and phosphorylated TDP-43 revealed minimal aggregations in the hippocampus of the hippocampal MSA patients. Our observations suggest a pathological variant of MSA that is characterized by severe involvement of hippocampal neurons. This phenotype may reinforce the importance of neuronal alpha-synucleinopathy in the pathogenesis of MSA. 相似文献
42.
Vascular Endothelial Growth Factor C Promotes Lymph Node Metastasis in a Rectal Cancer Orthotopic Model 总被引:5,自引:0,他引:5
Purpose Vascular endothelial growth factor C (VEGF-C), a novel member of the vascular endothelial growth factor family, is a relatively specific lymphangiogenic growth factor. It has been suggested that increased expression of VEGF-C in primary tumors is correlated with lymph node metastasis. We conducted this study to determine whether VEGF-C directly affects lymphangiogenesis and lymph node metastasis in colorectal cancer.Methods For an accurate analysis and clear visualization of metastases, the rectal cancer cell line, DLD1, was engineered to stably express green fluorescent protein (GFP) (DLD1/GFP). We implanted DLD1/GFP cells overexpressing VEGF-C orthotopically into the rectal walls of nude mice.Results Lymph node metastasis was confirmed in all (100%) of the mice bearing DLD1/GFP-VEGF-C tumors, but in only 25% of the mice bearing control tumors. There were more lymph node metastases per mouse in the mice bearing DLD1/GFP-VEGF-C tumors than in the mice bearing control tumors. There were no differences in cell growth and motility in vitro or in the resulting tumor volume from the implanted cells between the two groups. Immunohistochemical staining revealed that VEGF-C induced the growth of lymphatic vessels, which were enlarged in the tumor periphery and contained tumor cell emboli.Conclusion These results suggest that VEGF-C-induced lymphangiogenesis mediates tumor spread and the formation of lymph node metastasis. 相似文献
43.
Postoperative complications after induction chemoradiotherapy in patients with non-small-cell lung cancer 总被引:1,自引:0,他引:1
Shiro Fujita Nobuyuki Katakami Yutaka Takahashi Keiko Hirokawa Akihiko Ikeda Chiharu Tabata Tadashi Mio Michiaki Mishima 《European journal of cardio-thoracic surgery》2006,29(6):896-901
Objective: This study evaluates the risks of postoperative complications in 124 patients with non-small-cell lung cancer who received pre-operative induction chemoradiotherapy and surgery. Methods: All patients with non-small-cell lung cancer who underwent surgery after induction therapy between January 1990 and December 2003 were reviewed. We adopted univariate and multiple logistic regression models to identify predictors that increased the incidence of postoperative complications. Results: Of 124 patients, 59 received carboplatin and docetaxel, 53 received cisplatin and etoposide, and 12 received other platinum-based combinations. Pre-operative thoracic radiotherapy was performed concurrently with chemotherapy. The median dose to the primary tumor was 40 Gy, and 29 patients (23.4%) received radiotherapy of more than 45 Gy before surgery. There were 25 pneumonectomies (20.2%). The overall postoperative mortality was 9 of 124 patients (7.3%), and complications developed in 54 patients (43.5%). Multivariate analysis demonstrated that only thoracic radiotherapy of more than 45 Gy predicted postoperative complications (P = 0.021; odds ratio, 3.620; 95% confidence interval, 1.214–10.797). Conclusions: Thoracic radiotherapy of more than 45 Gy, in combination with chemotherapy, was a significant risk factor for postoperative complications. 相似文献
44.
Naoki Ishii Noriyuki Horiki Toshiyuki Itoh Masayo Uemura Masataka Maruyama Shoko Suzuki Shino Uchida Yusuke Izuka Katsuyuki Fukuda Yoshiyuki Fujita 《Surgical endoscopy》2010,24(2):335-342
Background
Superficial esophageal neoplasias resected in piecemeal manner with endoscopic mucosal resection (EMR) sometimes recur locally, and additional treatments need to be developed. Efficacy and safety of endoscopic submucosal dissection (ESD) for esophageal neoplasias are not sufficiently demonstrated, so we conducted a retrospective study to evaluate the efficacy and safety of ESD for superficial esophageal neoplasias. 相似文献45.
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis 总被引:21,自引:0,他引:21
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46.
Kansui Y Ohtsubo T Goto K Oniki H Yamasaki T Fukuhara M Ohta Y Matsumura K 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2012,34(2):140-144
It has been shown that aging and hypertension are important risk factors to promote renal damage. However, little data are available on the effect of obesity on the progression of renal damage, especially in young and middle-aged individuals. The aim of this study was to determine the association between body mass index (BMI) and renal function evaluated by estimated glomerular filtration rate (eGFR) in Japanese men. We studied the cross-sectional association of BMI with eGFR in 3872 Japanese men in a work-site population (18-64 y; mean age 42.1 ± 0.2 y). Estimated glomerular filtration rate was calculated by a novel equation for Japanese men. Estimated glomerular filtration rate was negatively correlated with age, systolic blood pressure (SBP), hemoglobin A1c (HbA1c), and BMI. We performed multiple regression analysis, controlling for factors, such as SBP, low-density lipoprotein-cholesterol, gamma-glutamyl transpeptidase, age, HbA1c, and uric acid. The association between age and eGFR was highly statistically significant. In addition, BMI was still significantly associated with eGFR independently of SBP. Moreover, mean eGFR, which was adjusted for age, SBP, HbA1c, serum uric acid, and gamma-glutamyl transpeptidase, decreased from 88.9 mL/min/1.73 m(2) in the first quartile of BMI to 87.5 mL/min/1.73 m(2) in the second, 86.9 mL/min/1.73 m(2) in the third, and 85.9 mL/min/1.73 m(2) in the fourth quartile (test for trend, P < .0001). These results show that a close relationship is present between obesity and decreased eGFR in Japanese men. Keeping appropriate body weight, in addition to appropriate blood pressure, in young and middle age may be important to prevent renal damage in older age. 相似文献
47.
Osamu Nagayama Akira Koike Takeya Suzuki Masayo Hoshimoto-Iwamoto Hitoshi Sawada Tadanori Aizawa 《The journal of physiological sciences : JPS》2010,60(2):137-142
The overshoot in oxygen uptake ([(V)\dot] \dot{\rm{V}} O2 overshoot) during recovery from maximal exercise is thought to reflect an overshoot in cardiac output. We investigated whether
this phenomenon is related to cardiopulmonary function during exercise in cardiac patients. A total of 201 consecutive patients
with previous myocardial infarction underwent cardiopulmonary exercise testing (CPX). An apparent [(V)\dot] \dot{\rm{V}} O2 overshoot during the recovery from CPX (6.5 ± 8.1% increase relative to the peak [(V)\dot] \dot{\rm{V}} O2) was observed in ten patients. A comparison of patients with the [(V)\dot] \dot{\rm{V}} O2 overshoot to those without the [(V)\dot] \dot{\rm{V}} O2 overshoot revealed that the former had a significantly lower left ventricular ejection fraction (40.1 ± 19.1 vs. 55. 2 ±
14.9%, respectively, p = 0.002) and larger left ventricular diastolic and systolic dimensions. Patients with the [(V)\dot] \dot{\rm{V}} O2 overshoot also had a significantly lower peak [(V)\dot] \dot{\rm{V}} O2 (13.1 ± 6.1 vs. 18.1 ± 4.5 ml/min/kg, p < 0.001), lower Δ[(V)\dot] \dot{\rm{V}} O2/ΔWR (work rate) (6.6 ± 3.8 vs. 9.5 ± 1.7 mL/min/W, p < 0.0001), and a higher [(V)\dot] \dot{\rm{V}} E (minute ventilation)/[(V)\dot] \dot{\rm{V}} CO2 (carbon dioxide output) slope (45.0 ± 18.6 vs. 32.6 ± 6.6, p < 0.0001) than those without the overshoot. A [(V)\dot] \dot{\rm{V}} O2 overshoot during recovery from maximal exercise was found in 5% of patients with previous myocardial infarction. This condition,
which suggests a transient mismatch between cardiac contractility and afterload reduction, was found to be related to impaired
cardiopulmonary function during exercise. 相似文献
48.
Pharmacokinetics of ivermectin applied topically by whole‐body bathing method in healthy volunteers
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Atsushi Miyajima Takashi Hirota Mari Tashiro Wataru Noguchi Yayoi Kawano Takehisa Hanawa Akira Kigure Taichi Anata Yosuke Yamamoto Nae Yuasa Machi Koshino Yumi Shiraishi Kaoru Yuzawa Keita Akagi Takashi Yoshimasu Kuniko Makigami Masayo Komoda 《The Journal of dermatology》2017,44(4):406-413
As a novel administration method of ivermectin (IVM) for scabies treatment, we proposed a “whole‐body bathing method (WBBM)”. In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. Previously, we demonstrated that WBBM could deliver IVM to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole‐body bathing examination (second trial) were conducted in healthy volunteers. In both the first and second trials, after bathing in fluid containing IVM, the exposure in the stratum corneum was higher compared with that after taking IVM p.o. as reported previously. IVM was not detected in plasma at any sampling point after the whole‐body bathing in the second trial. Furthermore no serious adverse events were found. These results in both trials suggest that WBBM can deliver IVM to the human stratum corneum without systemic exposure or serious adverse effects in healthy volunteers, and at concentrations that would be adequate for scabies treatment. 相似文献
49.
Yasumasa Nishimura Kazuhiko Nakagawa Koji Takeda Masahiro Tanaka Yoshihiko Segawa Kayoko Tsujino Shunichi Negoro Nobukazu Fuwa Toyoaki Hida Masaaki Kawahara Nobuyuki Katakami Keiko Hirokawa Nobuyuki Yamamoto Masahiro Fukuoka Yutaka Ariyoshi 《International journal of radiation oncology, biology, physics》2007
50.
Dogru M Katakami C Miyashita M Hida E Uenishi M Tetsumoto K Kanno S Nishida T Yamanaka A 《Ophthalmology》2000,107(6):1144-1152
PURPOSE: To study the ocular surface disorder in patients with Avellino, granular, and lattice dystrophy, band keratopathy, and corneal leukoma before and after excimer laser phototherapeutic keratectomy. DESIGN: A prospective case-controlled study. PARTICIPANTS: A total of 45 eyes of 33 patients with superficial corneal opacities seen at Kobe Kaisei Hospital, Department of Ophthalmology, and 40 eyes of 20 normal control subjects were studied. INTERVENTION: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, tear film break up time (BUT), Schirmer test, tear film lipid layer interferometry, and conjunctival impression cytology. MAIN OUTCOME MEASURES: The patients and the control subjects were compared for prephototherapeutic keratectomy (PTK) tear function parameters, tear film lipid layer interferometry grade, goblet cell density, and conjunctival squamous metaplasia grade. Alterations of these parameters within 3 months after PTK were also looked for. RESULTS: The average pre-PTK corneal sensitivity and tear film break up time were lower in patients compared with control subjects before PTK. Tear film lipid layer interferometry grade and conjunctival squamous metaplasia grades were higher in the patients than the controls before PTK. All these parameters improved gradually and significantly after PTK. Goblet cell density was significantly lower in the patients compared with controls before PTK. Schirmer test results and goblet cell density did not show any significant alterations after PTK. CONCLUSIONS: Concurrent improvements in corneal sensitivity, tear film break up time, lipid layer interference grades, and conjunctival squamous metaplasia grades all point to the favorable effects of PTK on the ocular surface by improving the stability of the tear film and ocular surface health through attainment of a regular corneal surface and probably inducing qualitatively/quantitatively better mucin production by a healthier epithelium after PTK. 相似文献