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991.
Kodama Kenichiro Kawaoka Tomokazu Kosaka Masanari Johira Yusuke Shirane Yuki Miura Ryoichi Yano Shigeki Murakami Serami Amioka Kei Naruto Kensuke Ando Yuwa Kosaka Yumi Uchikawa Shinsuke Fujino Hatsue Nakahara Takashi Murakami Eisuke Okamoto Wataru Yamauchi Masami Miki Daiki Imamura Michio Kuroda Shintaro Kobayashi Tsuyoshi Ohdan Hideki Aikata Hiroshi Chayama Kazuaki 《Journal of gastroenterology》2022,57(9):676-683
Journal of Gastroenterology - Intrahepatic cholangiocarcinoma is the second most common primary cancer of the liver. It is highly malignant and its prognosis is very poor. Although there have been... 相似文献
992.
Yuno Nishida Tomokazu Kawaoka Michio Imamura Maiko Namba Yasutoshi Fujii Shinsuke Uchikawa Kazuki Ohya Kana Daijo Yuji Teraoka Kei Morio Hatsue Fujino Takashi Nakahara Masami Yamauchi Akira Hiramatsu Masataka Tsuge Hiroshi Aikata Shoichi Takahashi C. Nelson Hayes Takayuki Fukuhara Keiji Tsuji Keiko Arataki Yuko Nagaoki Yasuyuki Aisaka Koji Kamada Hideaki Kodama Kazuaki Chayama 《Internal medicine (Tokyo, Japan)》2021,60(6):829
Objective Lusutrombopag is a thrombopoietin receptor agonist that improves thrombocytopenia in patients with chronic liver disease scheduled to undergo invasive procedures. However, information on the efficacy of repeated lusutrombopag treatment and factors associated with the treatment is scarce. We analyzed the efficacy of repeated lusutrombopag treatment and the factors associated with a response to lusutrombopag. Methods Thirty-nine patients with chronic liver disease who received lusutrombopag treatment before undergoing invasive procedures were enrolled in this retrospective study. Of the 39 patients, 10 received lusutrombopag treatment multiple times for a total of 53 regimens of lusutrombopag treatment. Changes in platelet counts, the effects of repeated lusutrombopag treatment, and factors associated with response to lusutrombopag were analyzed. Results The median platelet count increased significantly from 4.5×104/μL before lusutrombopag treatment to 7.2×104/μL before the invasive procedure (p<0.01), and patients undergoing 49 of the 53 (92%) treatment regimens succeeded in undergoing invasive procedures without needing platelet transfusions. In patients who received lusutrombopag treatment repeatedly, the median platelet count significantly increased following the second administration of lusutrombopag, and the effects of lusutrombopag were similar between the first and second administration. A multivariate analysis identified the absence of diabetes mellitus (odds ratio, 5.56 for presence; p=0.04) as a significant and independent predictor of a response to lusutrombopag. Conclusion Lusutrombopag treatment significantly increased platelet counts in patients with chronic liver disease, making it possible to receive invasive procedures. The treatment produced identical effects when it was repeated. The efficacy of lusutrombopag might be decreased in patients with diabetes mellitus. 相似文献
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994.
Ogasawara Nobuhiko Kikuchi Daisuke Inoshita Naoko Nakayama Atsuhito Kohno Kei Ochiai Yorinari Hayasaka Junnosuke Suzuki Yugo Dan Nobuhihiro Okamura Takayuki Mitsunaga Yutaka Tanaka Masami Nomura Kosuke Odagiri Hiroyuki Yamashita Satoshi Matsui Akira Hoteya Shu Iizuka Toshiro 《Esophagus》2021,18(4):806-816
Esophagus - This study aimed to reveal long-term outcomes, such as incidence of metachronous esophageal and head and neck squamous cell carcinomas and overall survival rate, through long-term... 相似文献
995.
Single crystals of a Na–Ga–Si clathrate, Na8Ga5.70Si40.30, of size 2.9 mm were grown via the evaporation of Na from a Na–Ga–Si melt with the molar ratio of Na : Ga : Si = 4 : 1 : 2 at 773 K for 21 h under an Ar atmosphere. The crystal structure was analyzed using X-ray diffraction with the model of the type-I clathrate (cubic, a = 10.3266(2) Å, space group Pmn, no. 223). By adding Sn to a Na–Ga–Si melt (Na : Ga : Si : Sn = 6 : 1 : 2 : 1), single crystals of Na8GaxSi46−x (x = 4.94–5.52, a = 10.3020(2)–10.3210(3) Å), with the maximum size of 3.7 mm, were obtained via Na evaporation at 723–873 K. The electrical resistivities of Na8Ga5.70Si40.30 and Na8Ga4.94Si41.06 were 1.40 and 0.72 mΩ cm, respectively, at 300 K, and metallic temperature dependences of the resistivities were observed. In the Si L2,3 soft X-ray emission spectrum of Na8Ga5.70Si40.30, a weak peak originating from the lowest conduction band in the undoped Si46 was observed at an emission energy of 98 eV.Single crystals of a Na–Ga–Si clathrate, Na8Ga4.94Si41.06, of size 3.7 mm were grown via the evaporation of Na from a Na–Ga–Si–Sn melt with the molar ratio of Na : Ga : Si : Sn = 6 : 1 : 2 : 1 at 873 K for 3 h under an Ar atmosphere. 相似文献
996.
997.
There are limited data available on the relationship between multidrug-resistant bacteria and infection control activities in small to medium-sized hospitals. Therefore, we collected data on the use of alcohol-based hand sanitizers (ABHSs), personal protective equipment, antibiotics, and the levels of detectable bacteria between April 2014 and March 2015 in 11 Japanese hospitals. Average total antibiotic consumption was 100 defined daily doses per 1000 patient-days (PD), and average use of ABHSs, masks, plastic aprons, and gloves was 5 L per 1000 PD, and 1, 2, and 26 pieces per 1 PD, respectively. Average numbers of isolated (isolation rate) Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing bacteria, and multidrug-resistant Pseudomonas aeruginosa (MDRP) were 107 (8% of total bacterial tests performed), 51 (4%), and 4 (0.3%), respectively. Multivariate analyses of ABHS and tazobactam/piperacillin consumption showed a significant negative association with the MRSA isolation rate (adjusted R2 = 0.87). These findings suggest that hand hygiene is more important than antibiotic consumption in small to medium-sized hospitals. 相似文献
998.
Gustavo Pedraza-Alva Leonor Pérez-Martínez Laura Valdez-Hernández Karla F. Meza-Sosa Masami Ando-Kuri 《Immunological reviews》2015,265(1):231-257
In addition to its roles in controlling infection and tissue repair, inflammation plays a critical role in diverse and distinct chronic diseases, such as cancer, metabolic syndrome, and neurodegenerative disorders, underscoring the harmful effect of an uncontrolled inflammatory response. Regardless of the nature of the stimulus, initiation of the inflammatory response is mediated by assembly of a multimolecular protein complex called the inflammasome, which is responsible for the production of inflammatory cytokines, such as interleukin-1β (IL-1β) and IL-18. The different stimuli and mechanisms that control inflammasome activation are fairly well understood, but the mechanisms underlying the control of undesired inflammasome activation and its inactivation remain largely unknown. Here, we review recent advances in our understanding of the molecular mechanisms that negatively regulate inflammasome activation to prevent unwanted activation in the resting state, as well as those involved in terminating the inflammatory response after a specific insult to maintain homeostasis. 相似文献
999.
Harpal Singh Masayuki Shimojima Thanh Cao Ngoc Nguyen Vu Quoc Huy Tran Xuan Chuong An Le Van Masayuki Saijo Ming Yang Masami Sugamata 《Journal of medical virology》2015,87(12):2145-2148
Pteropine orthoreovirus, potentially of bat origin, has been reported to cause respiratory tract infections among human beings in Southeast Asia. Twelve IgG ELISA‐positive cases with antibodies against Pteropine orthoreovirus were detected among 272 human serum samples collected between March and June 2014 from in and around Hue City, Central Vietnam. These 12 cases were IgM ELISA negative. Neutralizing antibodies were also detected among six of these cases with the highest titer of 1:1,280 in 2 cases (both female, 32 and 68 years old, respectively). This is the first report of human infection with Pteropine orthoreovirus in Central Vietnam. These findings indicate the need for surveillance on Pteropine orthoreovirus infections in Southeast Asia to enable prevention and control strategies to be developed should a change in virulence occur. J. Med. Virol. 87:2145–2148, 2015. © 2015 The Authors. Journal of Medical Virology Wiley Periodicals, Inc. 相似文献
1000.