全文获取类型
收费全文 | 4155篇 |
免费 | 173篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 111篇 |
妇产科学 | 54篇 |
基础医学 | 615篇 |
口腔科学 | 73篇 |
临床医学 | 215篇 |
内科学 | 1118篇 |
皮肤病学 | 51篇 |
神经病学 | 310篇 |
特种医学 | 189篇 |
外科学 | 563篇 |
综合类 | 20篇 |
预防医学 | 95篇 |
眼科学 | 55篇 |
药学 | 329篇 |
中国医学 | 34篇 |
肿瘤学 | 489篇 |
出版年
2023年 | 17篇 |
2022年 | 40篇 |
2021年 | 73篇 |
2020年 | 54篇 |
2019年 | 63篇 |
2018年 | 92篇 |
2017年 | 50篇 |
2016年 | 75篇 |
2015年 | 84篇 |
2014年 | 119篇 |
2013年 | 117篇 |
2012年 | 208篇 |
2011年 | 250篇 |
2010年 | 140篇 |
2009年 | 138篇 |
2008年 | 229篇 |
2007年 | 264篇 |
2006年 | 244篇 |
2005年 | 268篇 |
2004年 | 258篇 |
2003年 | 289篇 |
2002年 | 286篇 |
2001年 | 40篇 |
2000年 | 37篇 |
1999年 | 75篇 |
1998年 | 76篇 |
1997年 | 64篇 |
1996年 | 57篇 |
1995年 | 42篇 |
1994年 | 54篇 |
1993年 | 62篇 |
1992年 | 45篇 |
1991年 | 44篇 |
1990年 | 44篇 |
1989年 | 42篇 |
1988年 | 39篇 |
1987年 | 37篇 |
1986年 | 34篇 |
1985年 | 25篇 |
1984年 | 30篇 |
1983年 | 26篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1980年 | 14篇 |
1979年 | 13篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1969年 | 7篇 |
1968年 | 5篇 |
1967年 | 5篇 |
排序方式: 共有4350条查询结果,搜索用时 15 毫秒
91.
Hiroshi Matsuura M.D. Masami Murai M.D. Takenori Hashimoto M.D. Takafumi Matsumoto M.D. Osamu Fukui M.D. 《The American journal of gastroenterology》1983,78(1):1-5
A rare case of systemic vasculitis with second component of complement (C2) deficiency was documented in a patient who developed colonic ulcerations, jejunal edema and dilatation, cutaneous ulcers, peripheral neuropathy, and psychosis. Colonoscopy revealed typical features of ischemic colitis and radiological examination showed ischemic changes in the jejunum and ileum. Histopathological examination of the cutaneous biopsy revealed typical necrotizing vasculitis. It is very likely that multiorgan involvement, including ischemic changes of the intestine, developed secondary to vasculitis associated with C2 deficiency. 相似文献
92.
Shingen Nakamura Momoyo Azuma Tomoko Maruhashi Kimiko Sogabe Ryohei Sumitani Munenori Uemura Masami Iwasa Shiro Fujii Hirokazu Miki Kumiko Kagawa Takashi Hiraga Noriyasu Kondo Hiromi Fujita Fumihiko Mahara Masahiro Abe 《Journal of infection and chemotherapy》2018,24(5):389-392
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by the SFTS virus (SFTSV). Clinical symptoms of SFTS often involve encephalopathy and other central neurological symptoms, particularly in seriously ill patients; however, pathogenesis of encephalopathy by SFTSV is largely unknown. Herein, we present case reports of three patients with SFTS, complicated by encephalopathy, admitted to Tokushima University hospital: one patient was a 63-year-old man, while the other two were 83- and 86-year-old women. All of them developed disturbance of consciousness around the 7th day post onset of fever. After methylprednisolone pulse therapy of 500 mg/day, all of them recovered without any neurological sequelae. SFTSV genome was not detected in the cerebrospinal fluid of 2 out of the 3 patients that were available for examination. In these patients, disturbance of consciousness seemed to be an indirect effect of the cytokine storm triggered by SFTSV infection. We propose that short-term glucocorticoid therapy might be beneficial in the treatment of encephalopathy during early phase of SFTSV infection. 相似文献
93.
Yutaka Ueda Tomotaka Sobue Akiko Morimoto Tomomi Egawa-Takata Chie Hashizume Hisayo Kishida Satomi Okamoto Kiyoshi Yoshino Masami Fujita Takayuki Enomoto Yoshimi Tomine Jun Fukuyoshi Tadashi Kimura 《Journal of epidemiology / Japan Epidemiological Association》2015,25(1):50-56
Background
Finding ways to improve the cervical cancer screening rates among young women has been seen as a critical national health problem in many countries, including Japan. The aim of the present study was to evaluate the effects of a free-coupon program for cervical cancer screening conducted by a local government under financial support from the Japanese national government.Methods
The personal cervical cancer screening information was analyzed for all female residents of Toyonaka City, including any past screening history and clinical results since the year 2009, when a free-coupon program for screening was started. These results were compared to results from 2008, prior to implementation of the free-coupon screening program.Results
The screening rates of women eligible for the free-coupon peaked dramatically compared to women of similar age who paid for their screening; however, the rates for the ineligible-age population also increased significantly in parallel to those in the free-coupon program, possibly by indirect peer and publicity effects. In women aged 20 to 25 years, the consecutive screening rate after a free-coupon screening was significantly lower than for those women who received a regular residential screening. After a free-coupon screening, the rate for participating in consecutive screenings depended significantly on the institution where the participant received her first screening test.Conclusions
These results suggest that, for a generation of young women 20–25 years of age, a free-coupon program for cervical cancer screening was effective in increasing the first-time participation rate for screening; however, the increase in first-time participation did not lead to the expected increase in consecutive screenings.Key words: cervical cancer screening, free-coupon, screening rate, consecutive screening 相似文献94.
Masami Shibukawa Masaru Yanagisawa Ryota Morinaga Tomomi Shimasaki Shingo Saito Shao-ting Wang Yu-qi Feng 《RSC advances》2018,8(47):26849
The effects of temperature and background counterions on ion-exchange selectivity for alkali metal ions and tetraalkylammonium ions on strongly acidic cation-exchange resins have been investigated using superheated water ion-exchange chromatography (SW-IEC). We have found out that alkali metal ions show reversal in the order of the distribution coefficient (KD), from Li+ < Na+ < K+ < Rb+ in water at ordinary temperature to Rb+ < K+ < Na+ < Li+ in superheated water, when a relatively large cation such as cesium ion is used as the background counterion. The effect of counterion on the ion-exchange selectivity is enhanced with the ion-exchange resins of higher ion-exchange capacity and cross-linking degree. Tetraalkylammonium ions chosen as model ions for poorly hydrated ions also exhibit reversal in the order of KD at around 430 K in superheated water. However, the effect of the nature of alkali metal counterions on the change in KD values of tetraalkylammonium ions is rather small compared with the effect on the KD of alkali metal ions. These results are attributed to the change in local hydration structures of the ions in the ion-exchange resin due to dehydration of alkali metal ions enhanced by interionic contacts of the analyte ion with the coexisting counterion and lower hydration energy of the ions at elevated temperatures. Although it has been considered that temperature is not effective at changing the ion-exchange separation selectivity, significant selectivity changes can be achieved by SW-IEC.Metal ions in cation-exchange resins are dehydrated by interionic contacts with a co-existing counterion at elevated temperatures, which causes a drastic change in separation selectivity. 相似文献
95.
Yasuharu Matsunaga-Lee MD Yasuyuki Egami MD Kohei Ukita MD Akito Kawamura MD Hitoshi Nakamura MD Yutaka Matsuhiro MD Koji Yasumoto MD Masaki Tsuda MD Akihiro Tanaka MD Naotaka Okamoto MD Masamichi Yano MD PhD Ryu Shutta MD Yasushi Sakata MD PhD FACC FESC Masami Nishino MD PhD FACC FESC Jun Tanouchi MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):58-66
96.
97.
Vipoma of the Pancreas Complicating Ulcerative Colitis 总被引:2,自引:0,他引:2
Hidenori Yanagi M.D. Masato Kusunoki M.D. Youichirou Sakanoue M.D. Yasutsugu Shoji M.D. Takehira Yamamura M.D. Masami Murai M.D. Nobuteru Kikkawa M.D. Joji Utsunomiya M.D. 《The American journal of gastroenterology》1991,86(8):1066-1069
We report a case of vipoma of the pancreas in conjunction with ulcerative colitis in a 20-yr-old woman. Twenty months after the onset of ulcerative colitis, the patient complained of watery diarrhea and was found to have an electrolyte disorder. A pancreatic tumor was detected by ultrasonography and computed tomography, along with an elevation of serum vasoactive intestinal polypeptide (VIP). The secretory diarrhea diminished dramatically, and the serum VIP level decreased into the normal range immediately after resection of the pancreatic tumor. Immunohistochemical staining revealed a pancreatic vipoma. Despite removal of the vipoma, she underwent restorative proctocolectomy and ileal J-pouch anal anastomosis 2 yr later due to progression of the ulcerative colitis. Postoperative course was uneventful, with excellent functional results. Knowledge of this rare condition accompanying ulcerative colitis may help in the management of the patient with an atypical clinical course. 相似文献
98.
Shuya Kusumoto Itsuro Jinnai Katsuro Itoh Nobutaka Kawai Tohru Sakata Akira Matsuda Kazunori Tominaga IKUO Murohashi Masami Bessho Kunitake Harashima & Atsuko Heshiki 《British journal of haematology》1996,99(3):649-655
Sixty-one consecutive patients with multiple myeloma were studied with magnetic resonance (MR) imaging of the spine. Sagittal T1-weighted and short inversion time (TI) inversion recovery (STIR) images were obtained. The MR patterns of the bone marrow were classified as diffuse (D) ( n = 26), nodular (N) ( n = 11), D + N ( n = 13) or normal (n) ( n = 11). Abnormal patterns were seen in 50 (82%) of the 61 patients. Correlations were found between the MR imaging patterns and some laboratory findings (WBC, haematocrit, platelet count, serum albumin, and percentage of marrow plasmacytosis). The survival of the patients with abnormal MRI patterns was significantly poorer than that of the patients with normal patterns. However, the survival of patients with a nodular pattern did not differ from those with a normal pattern. The MR imaging pattern of the bone marrow in patients with multiple myeloma is a useful factor in the assessment of prognosis. 相似文献
99.
Masami Taniguchi Naomi Tsurikisawa Noritaka Higashi Hiroshi Saito Haruhisa Mita Akio Mori Hiroki Sakakibara Kazuo Akiyama 《Allergology international》2007,56(2):97-103
Churg-Strauss syndrome (CSS) is characterized by the presence of asthma, eosinophilia, and small-vessel vasculitis with granuloma. It is a distinct entity, as determined from all classifications of systemic vasculitis. The poor prognostic factors in CSS are renal insufficiency, cardiomyopathy, severe gastrointestinal (GI) tract, and central nervous systems (CNS) involvement. The initial management of CSS should include a high dose of a corticosteroid: prednisone at 1 mg/kg/day or its equivalent for methylprednisolone with tapering over 6 months. In patients with severe or rapidly progressing CSS, the administration of methylprednisolone pulse at 1 g/body/day for 3 days is recommended. When corticosteroid therapy does not induce remission, or when patients have poor prognostic factors, immunosuppressive cytotoxic therapy is indicated. However, some patients with severe CSS often show resistance to conventional treatment. We think that IVIG therapy is a hopeful candidate for second-line treatment for CSS patients, particularly in the case of neuropathy and/or cardiomyopathy, which are resistant to conventional therapy. However, there is not much evidence supporting the effectiveness of IVIG in CSS, and the mechanisms underlying the action of IVIG remain unclear. Now we are performing clinical trials of IVIG therapy for CSS patients who are resistant to conventional treatment, through a nationwide double-blinded placebo-controlled study in Japan. 相似文献
100.
Takatsugu Yamamoto Mizue Tamura Toshikazu Hamauzu Akiko Nakayama Kazuo Kawasugi Masahide Kamakura Tadatoshi Kinoshita Yasushi Kuyama Masami Yamanaka Li-man Wang Masaki Sanaka Satoru Mineshita 《Journal of gastroenterology》1997,32(2):241-245
A 45-year-old man with intestinal Behçet's disease noticed an enlarged right cervical lymph node, and was diagnosed with diffuse large cell type, non-Hodgkin's lymphoma. The intrapelvic lymph tract was markedly deformed because of recurrent ileocecal ulceration, and conventional lymphoscintigraphy with a common tracer did not abolish the suspicion that lymphoma cells may have invaded the lymph nodes. Dynamic lymphoscintigraphy with a new tracer,99mtechnetium-diethylene triamine pentaacetic acid-human serum albumin, because of its high detection sensitivity, was very useful for excluding this suspicion, and for determining the clinical stage of lymphoma. Combination induction chemotherapy led to complete remission without any adverse effects, but subsequent supportive therapy with same protocol could not be completed because of progression of the intestinal lesions. Special management for the intestinal lesions, such as bowel rest, may be essential with chemotherapy for patients with intestinal Behçet's disease. 相似文献