Propranolol as a novel, effective spermicide: preliminary findings

The efficacy and tolerability of 80 mg propranolol tablets as a vaginal contraceptive were studied in 198 fertile women for 11 months. The calculated one year life table pregnancy rate was 3.4/100 women and the Pearl index was 3.9/100 women years. No major adverse effects were encountered. The findings suggested that propranolol is an effective vaginal contraceptive whose failure rate compares favourably with that of other methods of contraception. Further study of propranolol and similar compounds is warranted.     

Suicide: the unmet challenge of the trauma system

HYPOTHESIS: We hypothesized that a significant number of injuries and deaths due to suicide occurred in patients undergoing psychiatric treatment. DESIGN: We performed a retrospective cohort study of patients who committed suicide and patients with intentional self-inflicted injury. SETTING: San Francisco General Hospital in San Francisco, Calif, and the San Francisco Violent Injury Reporting System. PATIENTS: We retrospectively reviewed the San Francisco General Hospital records for all attempted and fatal suicides during calendar years 2001 and 2002. Data were merged with suicide data collected by the San Francisco Violent Injury Reporting System. RESULTS: Two hundred thirty-five suicides occurred between January 1, 2001, and December 31, 2002. One hundred thirty-two patients (56%) who committed suicide had a known mental health disorder at the time of their suicide. One hundred fifteen (87.1%) of those with a known mental health disorder had received psychiatric treatment at some point. Ninety-one patients (68.9%) with a known mental health disorder who committed suicide were receiving psychiatric treatment at the time of suicide. One hundred sixty-five (70%) of those who committed suicide had a traumatic mechanism of death. During the same 2-year period, 3106 trauma patients were admitted to San Francisco General Hospital. Fifty-five (2%) sustained intentional self-inflicted injuries. Ten (18%) of the 55 patients with intentional self-inflicted injury died after arrival at San Francisco General Hospital. CONCLUSION: Creation of a feedback mechanism between the trauma and mental health systems has the potential to improve psychiatric care and prevent injury and death.