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排序方式: 共有109条查询结果,搜索用时 31 毫秒
91.
92.
Silins SL; Cross SM; Elliott SL; Pye SJ; Burrows JM; Moss DJ; Misko IS 《International immunology》1997,9(11):1745-1755
93.
目的检测恶性疟原虫氯喹抗性转运基因(Pfcrt)76编码多态性及其用该多态性显示恶性疟原虫对氯喹反应性进行评价.方法用套式PCR/RFLP技术检测现场采集的滤纸血滴上恶性疟原虫crt基因76编码的赖氨酸野生型多态性及苏氨酸突变型多态性,并对恶性疟原虫的氯喹反应性进行体内法测定.结果34份滤纸血样中,32份的恶性疟原虫crt基因76号编码为苏氨酸(突变型),突变型比例为94.12%;34份血样中21份做氯喹抗性体内观察,该21个病例中14份血样恶性疟原虫crt基因76号编码为突变型,体内法观察同样显示恶性疟原虫对氯喹有抗性,两种方法显示恶性疟原虫对氯喹有抗性的符合率为66.67%.结论套式PCR/RFLP检测Pfcrt基因76号编码多态性,其方法简便、快速,但其多态性对氯喹反应性的提示尚需进一步评价. 相似文献
94.
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96.
Nishikawa A; Tanakamura Z; Furukawa F; Lee IS; Kasahara K; Ikezaki S; Takahashi M 《Carcinogenesis》1998,19(2):365-368
The modifying effects of oltipraz on induction of glandular stomach
carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were
investigated in a total of 120 male 6-week-old Wistar rats, divided into
six groups. Groups 1-3 (30 animals each) were given 100 p.p.m. MNNG in
their drinking water for 10 weeks as an initiation treatment for gastric
cancer induction and respectively fed diets supplemented with 0.04%, 0.02%
and 0% oltipraz for 12 weeks, starting 1 week before and finishing 1 week
after the carcinogen exposure. Groups 4-6 (10 animals each) were similarly
treated without the application of MNNG. At the end of the 80th
experimental week, all surviving animals were autopsied and examined
histopathologically for the existence of gastric proliferative lesions. The
incidence and multiplicity of adenocarcinomas were significantly (P <
0.01) lower in group 1 than in group 3. In addition, the multiplicity of
atypical hyperplasias in the pyloric region was significantly (P < 0.05)
decreased in group 1 as compared with the group 3 value. No gastric
proliferative lesions were found in groups 4-6. In an additional short-term
experiment, oltipraz significantly reduced cell proliferative activity (P
< 0.01) and elevated glutathione levels (P < 0.05) in the glandular
stomach mucosa of rats treated with MNNG. Thus our results clearly indicate
that oltipraz can inhibit induction of proliferative glandular stomach
lesions by MNNG in the rat.
相似文献
97.
JM Hanson AM Wood R Seymour IS Petheram 《Journal of Medical Imaging and Radiation Oncology》2005,49(3):246-251
Total anomalous pulmonary venous drainage is a rare congenital anomaly. It usually involves a pulmonary to systemic venous shunt and most cases have a septal defect in order to survive. Anomalous pulmonary venous drainage with pulmonary venous shunting is an extremely rare and entirely benign entity. We present two such cases, in which there was atresia of the left superior pulmonary vein and drainage via a tortuous collateral vein to the left inferior pulmonary vein. This collateral was mistaken on plain film and CT for a pulmonary arteriovenous malformation. Awareness of this anomalous unilateral single pulmonary vein and its radiological appearances may help in avoiding unnecessary pulmonary angiography. 相似文献
98.
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia 总被引:11,自引:0,他引:11
Harmon DL; Woodside JV; Yarnell JW; McMaster D; Young IS; McCrum EE; Gey KF; Whitehead AS; Evans AE 《QJM : monthly journal of the Association of Physicians》1996,89(8):571-577
Mild hyperhomocysteinaemia is a major risk factor for vascular disease and
neural tube defects (NTDs), conferring an approximately three-fold relative
risk for each condition. It has several possible causes: heterozygosity for
rare loss of function mutations in the genes for 5,10-methylene
tetrahydrofolate reductase (MTHFR) or cystathionine-&bgr;-synthase
(CBS); dietary insufficiency of vitamin co-factors B6, B12 or folates; or
homozygosity for a common 'thermolabile' mutation in the MTHFR gene which
has also been associated with vascular disease and NTDs. We quantified the
contribution of the thermolabile mutation to the hyperhomocysteinaemic
phenotype in a working male population (625 individuals). Serum folate and
vitamin B12 concentrations were also measured and their relationship with
homocysteine status and MTHFR genotype assessed. The homozygous
thermolabile genotype occurred in 48.4, 35.5, and 23.4% for the top 5, 10
and 20% of individuals repectively) ranked by plasma homocysteine levels,
compared with a frequency of 11.5% in the study population as a whole
establishing that the mutation is a major determinant of homocystein levels
at the upper end of the range. Serum folate concentrations also varied with
genotype, being lowest in thermolabile homozygotes. The MTHFR thermolabile
genotype should be considered when population studies are designed to
determine the effective homocysteine-lowering dose of dietary folate
supplements, and when prophylactic doses of folate are recommended for
individuals.
相似文献
99.
Gritsaev SV Abldulkadyrov KM Tiranova SA Kapustin SI Martynkevich IS Bessmel'tsev SS Rugal' VI Bakaĭ MP 《Terapevticheski? arkhiv》2004,76(12):68-73
AIM: To characterize patients with mixed myeloid neoplasias with proliferation of neutrophils, platelets and eosinophils. MATERIAL AND METHODS: Examination and treatment results were analysed for patients with atypical myeloid leukemia (n = 4), myelodysplastic syndrome (MDS, n = 1) and thrombocytosis, MDS and eosinophilia (n = 1). The examination included morphological, histological, cytogenetic and molecular tests. RESULTS: One patient with atypical chronic myeloid leukemia was prior diagnosed to have primarily MDS with a typical aberration of chromosome 5. Two other patients had an initial morphological picture of resistant anemia with blast excess, signs of myeloproliferation and extramedullary hemopoiesis. One and two months after the first examination they received transfusions of erythrocytic mass. Just then they were found to have splenomegaly and leukocytosis due to proliferating and maturating forms of neutrophils. The course of the disease in patients with MDS, thrombocytosis and normal karyotype and in patients with MDS, eosinophilia and combined chromosomal breaks including translocation (3;12)(q21;p13) was characterized by resistance to standard programs of polychemotherapy and transformation into acute myeloblastic leukemia. CONCLUSION: In some cases atypical CML is a stage of a natural course of MDS. Some MDS variants with eosinophilia and thrombocytosis should be referred to the group of mixed myeloid neoplasias. 相似文献
100.
AnewratmodelofportalhypertensioninducedbyintraportalinjectionofmicrospheresLIXiangNong1,ISBenjamin2andBAlexander2Subjecthead... 相似文献