全文获取类型
收费全文 | 6668篇 |
免费 | 477篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 195篇 |
妇产科学 | 211篇 |
基础医学 | 995篇 |
口腔科学 | 154篇 |
临床医学 | 688篇 |
内科学 | 1395篇 |
皮肤病学 | 170篇 |
神经病学 | 810篇 |
特种医学 | 162篇 |
外科学 | 635篇 |
综合类 | 19篇 |
一般理论 | 3篇 |
预防医学 | 577篇 |
眼科学 | 124篇 |
药学 | 454篇 |
中国医学 | 26篇 |
肿瘤学 | 502篇 |
出版年
2024年 | 12篇 |
2023年 | 69篇 |
2022年 | 95篇 |
2021年 | 201篇 |
2020年 | 121篇 |
2019年 | 198篇 |
2018年 | 208篇 |
2017年 | 194篇 |
2016年 | 212篇 |
2015年 | 213篇 |
2014年 | 248篇 |
2013年 | 353篇 |
2012年 | 555篇 |
2011年 | 582篇 |
2010年 | 291篇 |
2009年 | 273篇 |
2008年 | 419篇 |
2007年 | 430篇 |
2006年 | 392篇 |
2005年 | 408篇 |
2004年 | 347篇 |
2003年 | 329篇 |
2002年 | 317篇 |
2001年 | 73篇 |
2000年 | 63篇 |
1999年 | 80篇 |
1998年 | 39篇 |
1997年 | 44篇 |
1996年 | 31篇 |
1995年 | 20篇 |
1994年 | 26篇 |
1993年 | 18篇 |
1992年 | 32篇 |
1991年 | 40篇 |
1990年 | 34篇 |
1989年 | 17篇 |
1988年 | 21篇 |
1987年 | 19篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1984年 | 21篇 |
1983年 | 10篇 |
1982年 | 8篇 |
1981年 | 11篇 |
1980年 | 7篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1974年 | 5篇 |
1973年 | 5篇 |
排序方式: 共有7169条查询结果,搜索用时 15 毫秒
31.
Kuniaki Tanaka Yoshifumi Tomita Mari Tsuruta Fumiko Konishi Masao Okuda Kunisuke Himeno Kikuo Nomoto 《Immunopharmacology and immunotoxicology》1990,12(2):277-291
Chlorella vulgaris, an unicellular green algae, or its acetone-extract (Ac-Ex) were administered orally to Meth A tumor bearing BALB/c or (BALB/c DBA/2)F1 (CDF1) mice. When CDF1 mice were fed daily with 10% dried powder of Chlorella vulgaris (CVP) containing diet before and after Meth A tumor inoculation, the growth of rechallenged Meth A tumor was significantly suppressed in an antigen-specific manner. Augmentation of antitumor resistance was exhibited also by Winn assay using lymph node cells of tumor-bearing mice orally administered with CVP or Ac-Ex. Antigen-specific concomitant immunity in these mice were mediated by cytostatic T cells but not by cytotoxic T cells. Natural killer cells seemed not to contribute in antitumor resistance in this system. 相似文献
32.
Mori S Endo M Nishizawa K Ohno M Miyazaki H Tsujita K Saito Y 《Physics in medicine and biology》2005,50(22):N359-N370
The prototype cone-beam CT (CBCT) has a larger beam width than the conventional multi-detector row CT (MDCT). This causes a non-uniform angular distribution of the x-ray beam intensity known as the heel effect. Scan conditions for CBCT tube current are adjusted on the anode side to obtain an acceptable clinical image quality. However, as the dose is greater on the cathode side than on the anode side, the signal-to-noise ratio on the cathode side is excessively high, resulting in an unnecessary dose amount. To compensate for the heel effect, we developed a heel effect compensation (HEC) filter. The HEC filter rendered the dose distribution uniform and reduced the dose by an average of 25% for free air and by 20% for CTDI phantoms compared to doses with the conventional filter. In addition, its effect in rendering the effective energy uniform resulted in an improvement in image quality. This new HEC filter may be useful in cone-beam CT studies. 相似文献
33.
34.
Kiyoshi Imaizumi Junko Kimura Mari Matsuo Kenji Kurosawa Mitsuo Masuno Norio Niikawa Yoshikazu Kuroki 《American journal of medical genetics》2002,107(1):58-60
We describe a de novo balanced reciprocal translocation between the long arms of chromosomes 5 and 8 [46,XX,t(5;8)(q35;q24.1)] in a 15-month-old girl with a typical Sotos syndrome phenotype. Involvement of the 5q35 region was previously reported (Maroun et al. [1994: Am J Med Genet 50:291-293]) as one of translocation breakpoints in the present patient. We suggest that the gene responsible for Sotos syndrome is located to a distal long-arm region of chromosome 5. 相似文献
35.
B Desablens J L Sebert J F Claisse A Pruna A Marié J Delobel J Messerschmitt 《Annales de médecine interne》1985,136(2):114-120
Acute hypercalcaemia was observed in a 54 year old woman followed up over a five year period for a lymphocytic non-Hodgkin lymphoma, a complication which is rare in chronic lymphoproliferative disorders except multiple myeloma. This case is of interest from 3 points of view: haematological: the simultaneous occurrence of hypercalcaemia (4.80 mmol/l) and of a leukaemic phase (19,300 lymphocytes/mm3) with no signs of "transformation" of the haemopathy; physiopathological: increased osteoclastic bone resorption and a rise in serum parathormone (0.21 to 4.82 ng/ml); therapeutic: efficacy of oral ethane 1, hydroxy 1, 1 diphosphonate (20 mg/kg/day) in treating the hypercalcaemia. 相似文献
36.
Jair de Jesus Mari 《Social psychiatry and psychiatric epidemiology》1987,22(3):129-138
Summary The aim of this study was to assess the prevalence of psychiatric disturbance in three primary medical care settings (Brasilandia, Servidor and Barra Funda) in a large city of a developing country and the effect of relevant sociodemographic factors (sex, age, marital status, occupation, migration, colour of skin and housing) on minor psychiatric morbidity.The prevalence rates of psychiatric morbidity were estimated at two levels: for minor and for severe psychiatric disturbance. The extent of minor psychiatric morbidity was found to be very high in the three primary medical care clinics (Brasilandia 56%, Servidor 50% and Barra Funda 47%) and about one-quarter of persons attending each clinic presented a severe psychiatric disturbance.Two factors were found to be associated with minor psychiatric morbidity (sex and family income per capita) when the joint effects of the sociodemographic variables were investigated. Women were more likely than men to present a minor psychiatric disturbance and the lower the family income the higher the risk of minor psychiatric morbidity. These findings are discussed in the light of the mental health of the urban poor living in the large cities of developing countries. 相似文献
37.
Herkama Sanna Kontio Mari Sainio Miia Turunen Tiina Poskiparta Elisa Salmivalli Christina 《Prevention science》2022,23(6):954-968
Prevention Science - The long-term sustainment of bullying prevention programs has rarely been investigated. This study addresses this gap by identifying facilitators and barriers to the systematic... 相似文献
38.
Catherine Lunt Christopher Dowrick Mari Lloyd-Williams 《Health & social care in the community》2021,29(5):1201-1221
There is a lack of robust evidence regarding outcomes for day care use among older people living with long-term conditions (LTCs). Day care is provided by independent, private and voluntary and charitable sectors. This systematic review aims to establish current evidence of outcomes for older people with LTCs attending day care services and outcomes on carers, across all service models. Narrative synthesis of quantitative and qualitative data was undertaken. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic literature search was carried out across eight electronic databases and reference lists of key journals between 2004 and October 2020 were searched. Searches returned 1,202 unique titles. Forty-five articles from 16 countries met the criteria on review of title, abstract and full article. There is limited evidence suggesting improved levels of perceived psychological health, quality of life, perceived general health, physical health and functioning for older people attending day care who have LTCs. The respite function of day care resulted in positive outcomes for carers. Studies evaluating outcomes for participants or carers were limited in quantity and quality. There is limited information regarding outcomes for day care attendance for older people with multiple LTCs from existing literature. Further research focusing on LTCs and day care attendance would benefit this field. 相似文献
39.
Mari A 《International archives of allergy and immunology》2002,129(4):286-295
BACKGROUND: IgE to cross-reacting carbohydrate determinants has already been described by several authors, but their function and distribution are still a matter of debate. In previous studies we showed how the presence of IgE to bromelain could be a useful and simple marker of the presence of IgE to carbohydrate epitopes. METHODS: A survey of 1,831 subjects with a suspected allergic respiratory disease has been carried out by detecting IgE to bromelain. Data were analysed on the basis of demographical and allergological parameters. To find out whether a glycoprotein is capable of triggering an allergic reaction, 1,076 subjects were also skin tested with several purified molecules bearing carbohydrate side chains differing in number, composition and complexity. RESULTS: An overall prevalence of 23% of positive IgE to cross-reacting carbohydrate determinants was recorded. Prevalence varied when subsets of non-allergic (5%), non-pollen-allergic (10%), and pollen-allergic (31%) subjects were considered. Prevalence further increased in subsets with multiple pollen sensitization (71%), and with a previous pollen immunotherapy course (46%), whereas minor differences were found in gender and age distribution. Almost all the allergenic extracts recorded negative in the skin test gave a positive IgE test in vitro. A higher correlation was found mainly with plant-derived allergenic extracts, whereas a lower one was recorded with mites and fungi. Horseradish peroxidase was the only glycoprotein capable of exerting a positive skin test in 21% of the subjects with IgE to cross-reacting carbohydrate determinants, 80% of them having IgE to the HRP molecule. CONCLUSIONS: IgE to cross-reacting carbohydrate determinants are common among the allergic population and the binding to skin test negative allergenic extracts further confirms their poor biological activity. Further studies on horseradish peroxidase should be carried out to define the role of the glycan side chains in its allergenic activity. 相似文献
40.
Elise Pelgrims Sally Ann Lynch Laurens Hannes Mariëtte J. V. Hoffer Cindy Melotte Arie Van Haeringen Ann Swillen Jeroen Breckpot 《American journal of medical genetics. Part A》2023,191(7):1889-1899
Triplication of chromosomal region 1p36.3 is a rare genomic rearrangement. In this report, we delineate the phenotypic spectrum associated with 1p36.3 triplications. We describe four patients with microtriplications of variable size, but with a strong phenotypic overlap, and compare them to previously described patients with an isolated triplication or duplication of this region. The 1p36.3 triplication syndrome is associated with a distinct phenotype, characterized by global developmental delay, moderate intellectual disability, seizures, behavioral problems, and specific facial dysmorphic features, including ptosis, hypertelorism, and arched eyebrows. The de novo occurrence of these microtriplications demonstrates the reduced reproductive fitness associated with this genotype, in contrast to 1p36.3 duplications which are mostly inherited and can be associated with similar facial features but with a less severe developmental phenotype. The shared triplicated region encompasses four disease-related genes of which GABRD and SKI are most likely to contribute to the phenotype. 相似文献