全文获取类型
收费全文 | 36575篇 |
免费 | 2505篇 |
国内免费 | 170篇 |
专业分类
耳鼻咽喉 | 519篇 |
儿科学 | 859篇 |
妇产科学 | 655篇 |
基础医学 | 4246篇 |
口腔科学 | 664篇 |
临床医学 | 3851篇 |
内科学 | 8660篇 |
皮肤病学 | 418篇 |
神经病学 | 3644篇 |
特种医学 | 1491篇 |
外国民族医学 | 1篇 |
外科学 | 6418篇 |
综合类 | 226篇 |
一般理论 | 18篇 |
预防医学 | 2162篇 |
眼科学 | 475篇 |
药学 | 2038篇 |
中国医学 | 45篇 |
肿瘤学 | 2860篇 |
出版年
2024年 | 29篇 |
2023年 | 255篇 |
2022年 | 410篇 |
2021年 | 924篇 |
2020年 | 594篇 |
2019年 | 923篇 |
2018年 | 1157篇 |
2017年 | 851篇 |
2016年 | 851篇 |
2015年 | 1021篇 |
2014年 | 1457篇 |
2013年 | 1956篇 |
2012年 | 2732篇 |
2011年 | 2924篇 |
2010年 | 1717篇 |
2009年 | 1692篇 |
2008年 | 2522篇 |
2007年 | 2656篇 |
2006年 | 2473篇 |
2005年 | 2386篇 |
2004年 | 2153篇 |
2003年 | 2015篇 |
2002年 | 1814篇 |
2001年 | 295篇 |
2000年 | 184篇 |
1999年 | 247篇 |
1998年 | 427篇 |
1997年 | 333篇 |
1996年 | 249篇 |
1995年 | 242篇 |
1994年 | 194篇 |
1993年 | 183篇 |
1992年 | 107篇 |
1991年 | 122篇 |
1990年 | 95篇 |
1989年 | 82篇 |
1988年 | 67篇 |
1987年 | 63篇 |
1986年 | 64篇 |
1985年 | 73篇 |
1984年 | 88篇 |
1983年 | 91篇 |
1982年 | 86篇 |
1981年 | 83篇 |
1980年 | 67篇 |
1979年 | 37篇 |
1978年 | 37篇 |
1977年 | 29篇 |
1975年 | 26篇 |
1974年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
Marc Elieson Timothy Mixon John Carpenter 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2012,39(6):884-889
Although rare, coronary artery stent infections are associated with a high mortality rate. Since the introduction of coronary stents in 1987, only 16 cases of infection have been reported. We report a new case in a 66-year-old woman who had undergone a difficult percutaneous coronary intervention procedure, during which 3 overlapping stents were implanted in the mid portion of the right coronary artery. Twenty-two days after the procedure, the patient died. Autopsy revealed the cause of death to be pericardial tamponade due to rupture of the right ventricular myocardium. The stented portion of the right coronary artery was enveloped by an abscess, and purulent material completely occluded the stents. Cultures of the myocardium were positive for methicillin-resistant Staphylococcus aureus.
We conducted a review of the literature on coronary artery stent infections. Data suggest that early-onset infections (<10 days after stent implantation) are potentially amenable to medical therapy alone, but late-onset infections (≥10 days after implantation) or major complications necessitate combined surgical and medical therapy. Medical therapy consists of broad-spectrum antibiotics. Surgical intervention includes stent removal if possible, and abscess drainage or perforation repair when indicated.Key words: Blood vessel prosthesis implantation/adverse effects, coronary stent infections, prosthesis-related infections/complications/diagnosis/therapy, stents/adverse effects, Staphylococcus aureusCoronary artery stents have been in use for more than 2 decades. Stent infections are rare, hard to treat, and potentially devastating. Our treatment of a patient with a coronary stent abscess prompted us to review the literature. From our experience and the evaluation of previously reported cases,1–14 we propose an approach for diagnosing and treating these infections. 相似文献
992.
Patel SA Herfel BM Nolan MA 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2012,39(1):79-83
Colorectal cancer rarely metastasizes to the heart. In the world medical literature, we identified only 7 cases of well-documented colorectal cancer metastasis to the right atrium. Herein, we describe the case of a 72-year-old man in whom metastatic mucinous adenocarcinoma of the colon involved the right atrium and caused superior vena cava syndrome. To our knowledge, this is the first case report of sudden cardiac death due to embolization of metastatic colon cancer from the right atrium. We also present the first comprehensive case series review of this rare entity.Given improvements in diagnostic and therapeutic methods that have increased the longevity of many cancer patients, the detection of cardiac metastases is likely to increase in frequency. Accordingly, we recommend that previously asymptomatic cancer patients with a history of colorectal cancer who develop cardiac symptoms undergo prompt investigation for possible cardiac metastasis. 相似文献
993.
994.
995.
Michelle L. O'Donoghue Ajay Vaidya Rizwan Afsal Joakim Alfredsson William E. Boden Eugene Braunwald Christopher P. Cannon Tim C. Clayton Robbert J. de Winter Keith A.A. Fox Bo Lagerqvist Peter A. McCullough Sabina A. Murphy Rudolf Spacek Eva Swahn Fons Windhausen Marc S. Sabatine 《Journal of the American College of Cardiology》2012
996.
Christel Vanroy Dirk Vissers Yves Vanlandewijck Hilde Feys Steven Truijen Marc Michielsen 《Topics in stroke rehabilitation》2013,20(2):98-105
Background: Despite confirmed reduced physical activity (PA) after stroke in various stages of recovery, the type of activities stroke patients executed and the time spent at different activity levels have not been sufficiently verified with stroke-validated assessment tools.Design: Observational study.Objective: To determine PA of sub-acute stroke patients hospitalized in a rehabilitation centre (HOS) compared to chronic home-living stroke patients (HOM) using objective and self-reported measures during 2 weekdays and 1 weekend day.Methods: Fifteen HOS and 15 HOM patients wore a Sense Wear Pro 2 accelerometer (METs*minutes/24 h) and a knee-worn pedometer Yamax Digi Walker SW 200 (steps) and filled in a coded activity diary (kcal/24 h; METs*minutes/24 h) during three consecutive days.Results: In HOM significantly more steps (stepstotal HOM = 18722.6 ± 10063.6; stepstotal HOS = 7097.8 ± 5850.5) and higher energy expenditure (EE) levels (EEtotal HOM = 7759.34 ± 2243.04; EEtotal HOS = 5860.15 ± 1412.78) were measured. In this group less moderate activity (≥3–6 ≤ METs) was performed on a weekday (pday1 = 0.006; pday2 = 0.027) and in total (p = 0.037). Few therapy hours (physical, occupational and speech therapy, and psychological support) were provided in HOM compared to HOS (p < 0.001). Vigorous activities were only seen in HOM. In both groups few patients executed sport activities.Conclusions: In HOM significantly more steps were performed and higher EE values were measured. However, participation in moderate activities and time spent on therapy were less in HOM. Evaluating PA with quantitative measures is feasible in both chronic home-living and sub-acute hospitalized patients with stroke. 相似文献
997.
998.
Marc Thioux Agnesa Pillon Dana Samson Marie-Pierre de Partz Marie-Pascale Noël Xavier Seron 《Neurocase》2013,19(4-5):371-389
Abstract In this study, we examine the case of a patient (NM) who could comprehend and produce numerals despite impairment on comprehension tasks and a high degree of anomia for other categories of words. It will be claimed that NM suffered from an impairment to the semantic system affecting all categories except numerals and the series of days and months. The case of a patient presenting with the exact reverse dissociation has been described a few years ago by Cipolotti et al. (Brain 1991; 114: 619–37). We conclude that NM's pattern of performance provides evidence that numerals constitute a relevant and perhaps a distinct category at the semantic level. 相似文献
999.
Antonieta Nieto Marc Corral-Juan Antoni Matilla-Dueñas Francisco Martínez-Burgallo Fernando Montón 《Neurocase》2013,19(5):195-201
ABSTRACTAutosomal recessive spinocerebellar ataxia type 10 (SCAR10) caused by a homozygous c.132dupA mutation in the anoctamin 10 gene is infrequent and little is known about its cognitive profile. Three siblings (1 male) with this mutation were assessed with a neuropsychological battery measuring multiple cognitive domains. The deficits observed in one patient were in executive functions whereas the other two patients showed deficits in practically all the functions. Cognitive impairment seems to be a characteristic of the SCAR10 produced by this mutation, with a range from mild impairment, especially involving prefrontal systems, to a severe cognitive impairment suggesting widespread cerebral involvement. 相似文献
1000.
Previous research studies have reported many hemispherical asymmetries in cortical and subcortical anatomy, but only a subset of findings is consistent across studies. Here, we used improved Freesurfer-based automated methods to analyse the properties of the cortex and seven subcortical structures in 138 young adult subjects. Male and female subjects showed similar hemispheric asymmetries in gyral and sulcal structures, with many areas associated with language processing enlarged in the left hemisphere (LH) and a number of areas associated with visuospatial processing enlarged in the right hemisphere (RH). In addition, we found greater (non-directional) cortical asymmetries in subjects with larger brains. Asymmetries in subcortical structures included larger LH volumes of thalamus, putamen and globus pallidus and larger RH volumes of the cerebellum and the amygdala. We also found significant correlations between the subcortical structural volumes, particularly of the thalamus and cerebellum, with cortical area. These results help to resolve some of the inconsistencies in previous studies of hemispheric asymmetries in brain anatomy. 相似文献