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91.
Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer. 总被引:5,自引:0,他引:5
Hening Ren Ximing Tang J Jack Lee Lei Feng Allen D Everett Waun Ki Hong Fadlo R Khuri Li Mao 《Journal of clinical oncology》2004,22(16):3230-3237
PURPOSE: Hepatoma-derived growth factor (HDGF), which is unrelated to hepatocyte growth factor, can stimulate DNA synthesis and cell proliferation on entering the nucleus. We hypothesize that HDGF plays an important role in biologic behavior of early-stage non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Ninety-eight patients with pathologic stage I NSCLC who underwent curative surgery were studied. Immunohistochemistry was used to determine the expression level of HDGF in the tumor specimens. The intensity of the protein staining and percentage of stained tumor cells were used to determine a labeling index. Statistical analyses, all two-sided, were performed to determine the prognostic effect of HDGF expression levels on clinical parameters and outcomes. RESULTS: The mean +/- standard deviation HDGF labeling index in the 98 tumors was 185 +/- 41. Patients whose tumors had higher HDGF indexes (>/= 185) had a significantly poorer probability of overall survival at 5 years after surgery than did those with lower HDGF indexes (0.26 v 0.82; P <.0001). Similarly, the 5-year disease-specific and disease-free survival probabilities were lower in those with higher HDGF indexes (0.42 v 0.92, and 0.34 v 0.71; P <.0001 and P =.0008; respectively). Multivariate analysis indicated that HDGF level was an independent predictor of overall, disease-specific, and disease-free survivals. CONCLUSION: Overexpression of HDGF is common in early-stage NSCLC. The expression level in tumor cells is strongly correlated with poor overall, disease-specific, and disease-free survivals, suggesting HDGF may be a powerful prognostic marker for patients with early-stage NSCLC. 相似文献
92.
93.
Loss of Fhit expression in head and neck squamous cell carcinoma and its potential clinical implication. 总被引:12,自引:0,他引:12
Shyh-Kuan Tai Janet I Lee K Kian Ang Adel K El-Naggar Khaled A Hassan Diane Liu J Jack Lee Hening Ren Waun K Hong Li Mao 《Clinical cancer research》2004,10(16):5554-5557
PURPOSE: Abnormalities of FHIT, a candidate tumor suppressor gene, have frequently been found in multiple malignancies, including head and neck squamous cell carcinoma (HNSCC). To define its role in HNSCC treated with surgery and postoperative radiotherapy (PORT), the Fhit protein expression status was investigated in 80 patients enrolled in a prospective Phase III clinical trial addressing the dose and fractionation regimen of PORT. EXPERIMENTAL DESIGN: Immunohistochemical staining of HNSCC tissue sections for Fhit expression was performed. The Fhit expression status was correlated with the clinicopathological characteristics and clinical course. The median follow-up duration was 4.9 years. RESULTS: Loss of Fhit expression was found in 52 of the 80 study patients (65%). There was not a significant association between Fhit expression and clinical characteristics. Patients whose tumor exhibited negative Fhit expression had a significantly worse 5-year overall survival duration [hazard ratio = 0.49; 95% confidence interval, 0.23-1.03; P = 0.05 (log-rank test)] than did those whose tumor exhibited positive Fhit expression. One third of the patients with a Fhit-negative tumor had distant metastasis during the follow-up period. Paradoxically, patients classified as high risk who had a Fhit-negative tumor experienced locoregional recurrence less often (18%) than did high-risk patients who had a Fhit-positive tumor (33%). CONCLUSIONS: Loss of Fhit expression is a poor prognostic indicator in patients with HNSCC. However, tumors lacking Fhit expression may be more sensitive to PORT and therefore more susceptible to locoregional control. 相似文献
94.
95.
阻断致瘤病毒复制的抗肿瘤药物筛选策略 总被引:2,自引:0,他引:2
许多病毒与人类恶性肿瘤的发生有关,阻断病毒与靶细胞的结合和融合、干扰病毒的复制和表达,抑制与病毒复制有关的酶等多个环节,将为抗肿瘤药物的筛选提供相关策略。 相似文献
96.
97.
自然抑制(NS)活性是一类尚未完全定性的细胞所具有的对多种免疫反应的非特异抑制作用.NS细胞表面不存在成熟B细胞、T细胞及巨噬细胞的表面标记,为此,我们研究了NS细胞和造血干细胞(HSC)间的关系,结果证明,NS细胞是处于增殖周期中的HSC,并证明小鼠NS细胞具有抑制肿瘤细胞增殖的作用.本实验中,我们研究人骨髓中NS细胞的体外抗肿瘤活性,并确定其作用模式和生物学特性. 相似文献
98.
目的:从部分中药成分中筛选新的非酶糖化(NEG)抑制荆,探讨其可能的作用机制。方法:通过建立体外牛血清白蛋白 NEG 系统以模拟糖尿病的体内环境,测定16种中药成分在不同浓度梯度(1×10~(-1)~1×10~(-7)mg/ml)下对糖化终末产物(AGEs 的荧光抑制率及半效抑制浓度(IC_(50)),并与公认的 NEG 抑制剂——氨基胍(AG)作比较。结果:槲皮素、芦丁、羟乙基芦丁、黄芩甙元、黄芩甙、水飞蓟素等具有明显的 NEG 抑制作用,其 IC_(50)分别为0.86mg/L、1.16mg/L、1.64mg/L、2.36mg/L、4.71mg/L 与1.75mg/L,相应的 AG 为0.38mg/L;部分补中益气类中药,其皂甙也有一定的 NEG 抑制作用,但较 AG 弱。结论:槲皮素等6种黄酮类中药在抑制体外蛋白 NEG 作用方面与 AG 相近,但机制可能与 AG 不同。某些抗衰老药物的作用机制可能与抑制蛋白 AGEs 形成有关。 相似文献
99.
目的:了解本院儿科抗菌药使用情况,以提高抗菌药物应用的合理性。方法:随机抽查,本院儿科住院患者病历142份,统计每种抗菌药的应用例数,应用天数。药品总消耗量,并按例数排序,统计联合用药情况。结果:本院儿科抗菌药使用率98.50%,其中联用两种药者54例,联用3种药者5例,共涉及6类15种抗菌药。结论:我院儿科住院患者抗菌药使用率较高,新型抗菌药应用广泛,合理用药有待改进。 相似文献
100.