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991.
R. K. Saxena Saurabh Varshney J. Singh A. Kaushal P. P. Bishnu 《Indian journal of otolaryngology and head and neck surgery》2001,53(2):154-157
A 9 years old boy reported with left nasal blockage, occasional left nasal bleeding, protruding left eye ball and widening of the nasal bridge for the last nine months. Clinical examination and radiological evaluation were suggeitive of fibrous dysplasia. Mass was excised by transfacial and transcranial approach. Histopathology of the excised muns proved to be a case of haemorrhagic cystic sino-nasal fibrous dysplasia. 相似文献
992.
993.
994.
Sivasubramanian Ramakrishnan Bharat Bhooshan Kukreti Lakshmy Ramakrishnan Salman Salahuddin Amit Pendharkar Ganesan Karthikeyan Balram Bhargava Rajnish Juneja Sandeep Seth Shyam S. Kothari Anita Saxena Vinay K. Bahl 《Pediatric cardiology》2013,34(8):1791-1796
Inflammation may be an important contributing factor to the progression of Eisenmenger syndrome (ES). Markers of systemic inflammation in ES have not been systematically studied. Inflammatory markers including high-sensitivity C-reactive protein (hs-CRP), interleukin-2 (IL-2), IL-6, and interferon-γ (IFN-γ) were measured in 42 consecutive ES patients (mean age, 24.3 ± 10.6 years) compared with their levels in 22 healthy control subjects. The patients were followed up for a mean duration of 16.3 ± 13.7 months. The levels of inflammatory markers were correlated with clinical and hemodynamic variables at baseline and the outcomes of death, hospitalization, and worsening World Health Organization (WHO) functional class at follow-up evaluation. Compared with the control subjects, ES patients showed a significant elevation in hs-CRP (2.99 ± 3.5 vs 1.1 ± 0.9 mg/dl; p = 0.002) and IFN-γ (41.3 ± 43.6 vs 10.4 ± 6.9 pg/ml; p < 0.001) levels. The levels of IL-2 and IL-6 also were elevated but did not differ significantly from those in the control subjects. The patients with hs-CRP levels higher than 3 mg/dl were significantly older (28.9 ± 10.6 vs 21.5 ± 9.8 years) and had a significantly shorter 6-min walk distance (421.5 ± 133.2 vs 493.3 ± 74.8 m). The levels of inflammatory markers did not correlate with baseline parameters or clinical outcomes. To conclude, the levels of hs-CRP and IFN-γ are significantly elevated in ES. Elevated hs-CRP in ES was associated with older age and shorter 6-min walk distance, but the levels of inflammatory markers were not predictive of clinical events. 相似文献
995.
996.
Rahul Naithani Rajat Kumar Renu Saxena M. Mahapatra 《Pediatric hematology and oncology》2013,30(2):100-102
Chronic myeloid leukemia (CML) is infrequent in children. The best-known treatment is stem cell transplant. In a country with limited resources like Sudan, such expensive therapy is not available. Alternative approaches are needed to help these children. The tyrosine kinase inhibiter–imatinib–might be an answer to this problem. The objective of this study is to determine the pattern of children with CML, their hematological response to imatinib, and tolerance and side effects to this drug. All patients with confirmed BCR-ABL by polymerase chain reaction (PCR) were included in this study. The relevant data were collected and the patients were started on imatinib. Response to treatment was assessed clinically and hematologicaly only. Cytogentics and molecular studies are not available. The average age of the 31 patient evaluated was 8.7 years, 2 patients were less than 1 year, and 5 patients, ie, 16%, were 2 years old or less. Chloroma was observed in 6 (19%) patients. The average of the white blood cell (WBC) count was 206.6 × 109/L and the platelet count average was 523 × 109/L. Two (6.5%) of the 31 patients presented as acute myeloid leukemia (AML). All patients had hematological remission within 2 months. Twenty-three (74%) had a sustained remission over an average follow-up period of 26 months (2–67 months). Six (19%) patients died with AML or sepsis. Side effects to imatinib were infrequent, observed in 4 out of 29 (13.7%) patients, and mild. One patient only needed dose modification. No resistance was observed during this period. CML patients present at an earlier age than in other parts of the world. Imatinib is safe and effective in treating pediatric CML where stem cell transplant in not available. Further cytogentics are important to monitor response and proper management. 相似文献
997.
Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: results of a pilot study 总被引:4,自引:0,他引:4
Moudgal NR; Murthy GS; Prasanna Kumar KM; Martin F; Suresh R; Medhamurthy R; Patil S; Sehgal S; Saxena BN 《Human reproduction (Oxford, England)》1997,12(3):457-463
A study of 140 days duration was performed to examine if human male
volunteers (n = 5) respond to ovine follicle stimulating hormone (oFSH)
immunization (administered adsorbed on Alugel on days 1, 20, 40 and 70) by
producing antibodies capable of both binding and neutralizing bioactivity
of human FSH. The kinetics of antibody production for both the immunogen
(oFSH) and the cross-reactive antigen (hFSH) were essentially similar. The
volunteers responded only to the first two immunizations. The boosters
given on days 40 and 70 were ineffective, probably because of the presence
of substantial amounts of circulating antibody to oFSH. Of the antibodies
generated to oFSH, 25-45% bound hFSH with a mean binding affinity of 0.65 x
10(9) +/- 0.53 M(-1). The binding capacities at the time of high (30-80
days of immunization) and low (>110 days) titres were 346 +/- 185 and
10.5 +/- 5.8 ng hFSH/ml respectively. During the period of high titre, free
serum FSH (value in normal males 1-5 ng/ml) was not monitorable. A 50
microl aliquot of the antiserum obtained from different volunteers between
days 30 and 80 and on day 140 blocked binding of (125)I-labelled hFSH to
its receptor by 82 +/- 9.7 and 53 +/- 12.2% respectively. The antibody
produced was specific for FSH, and no significant change in the values of
related glycoprotein hormones (luteinizing hormone/testosterone and thyroid
stimulating hormone/thyroxine) were recorded. Seminal plasma transferrin, a
marker of Sertoli cell as well as of seminiferous tubular function, showed
marked reduction (30-90%) following immunization with oFSH. Considering
that endogenous FSH remained neutralized for approximately one sperm cycle
only (65 days), the reduction in sperm counts (30-74%) exhibited by some
volunteers is encouraging. Immunization with oFSH did not result in any
significant changes in haematology, serum biochemistry or hormonal
profiles. There was no production of antibodies capable of interacting with
non- specific tissues. It is concluded that it should be possible to obtain
a sustained long-term blockade of endogenous FSH action in men by using
oFSH as an immunogen. This is a prerequisite for obtaining significant
reduction in the quality and quantity of spermatozoa produced, thus leading
to infertility.
相似文献
998.
999.
Hassan S Dashti Brian E Cade Gerda Stutaite Richa Saxena Susan Redline Elizabeth W Karlson 《Sleep》2021,44(3)
Study ObjectivesImplementation of electronic health record biobanks has facilitated linkage between clinical and questionnaire data and enabled assessments of relationships between sleep health and diseases in phenome-wide association studies (PheWAS). In the Mass General Brigham Biobank, a large health system-based study, we aimed to systematically catalog associations between time in bed, sleep timing, and weekly variability with clinical phenotypes derived from ICD-9/10 codes.MethodsSelf-reported habitual bed and wake times were used to derive variables: short (<7 hours) and long (≥9 hours) time in bed, sleep midpoint, social jetlag, and sleep debt. Logistic regression and Cox proportional hazards models were used to test cross-sectional and prospective associations, respectively, adjusted for age, gender, race/ethnicity, and employment status and further adjusted for body mass index.ResultsIn cross-sectional analysis (n = 34,651), sleep variable associations were most notable for circulatory system, mental disorders, and endocrine/metabolic phenotypes. We observed the strongest associations for short time in bed with obesity, for long time in bed and sleep midpoint with major depressive disorder, for social jetlag with hypercholesterolemia, and for sleep debt with acne. In prospective analysis (n = 24,065), we observed short time in bed associations with higher incidence of acute pain and later sleep midpoint and higher sleep debt and social jetlag associations with higher incidence of major depressive disorder.ConclusionsOur analysis reinforced that sleep health is a multidimensional construct, corroborated robust known findings from traditional cohort studies, and supported the application of PheWAS as a promising tool for advancing sleep research. Considering the exploratory nature of PheWAS, careful interrogation of novel findings is imperative. 相似文献
1000.
Kapoor K Arulmani U Heiligers JP Garrelds IM Willems EW Doods H Villalón CM Saxena PR 《British journal of pharmacology》2003,140(2):329-338
1. Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive trigeminal sensory nerves, seems to be involved in the pathogenesis of migraine. Hence, CGRP receptor antagonists may serve as a novel treatment for migraine. This study was therefore designed to investigate the effects of BIBN4096BS (100, 300 and 1000 microg kg-1, i.v.), a potent and selective CGRP receptor antagonist, on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs. Both vagosympathetic trunks were cut and phenylephrine was infused into the carotid artery (i.c.) to support carotid vascular tone. 2. Infusions of capsaicin (0.3, 1, 3 and 10 microg kg-1 min-1, i.c.) did not alter the heart rate, but dose-dependently increased the mean arterial blood pressure. This moderate hypertensive effect was not modified by BIBN4096BS. 3. Capsaicin infusion (10 microg kg-1 min-1, i.c.) increased total carotid, arteriovenous anastomotic and tissue blood flows and conductances as well as carotid pulsations, but decreased the difference between arterial and jugular venous oxygen saturations. These responses to capsaicin were dose-dependently blocked by BIBN4096BS. 4. Capsaicin infusion (10 microg kg-1 min-1, i.c.) more than doubled the jugular venous plasma concentration of CGRP. This effect was not blocked, but rather increased, by BIBN4096BS. 5. The above results show that BIBN4096BS behaves as a potent antagonist of capsaicin-induced carotid haemodynamic changes that are mediated via the release of CGRP. Therefore, this compound may prove effective in the treatment of migraine. 相似文献