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41.
Marriott I Miller JR Sahraei M 《Current opinion in investigational drugs (London, England : 2000)》2007,8(11):887-898
Despite current treatment strategies, osteomyelitis is often refractory and recurrent. The bacteria responsible for osteomyelitis can invade bone-forming osteoblasts, which are active participants in the generation of damaging inflammation and bone loss at sites of infection. Therefore, strategies promoting cell-mediated immune responses while limiting inflammation are required for the treatment of chronic bone infections. This review describes the mechanisms utilized by resident bone cells to perceive bacteria, recruit leukocytes to sites of infection and promote osteoclast-mediated bone destruction, as well as novel targets for the therapeutic intervention of these processes. 相似文献
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Giovanni F. Torelli Carmela Rozera Laura Santodonato Nadia Peragine Giuseppina D’Agostino Enrica Montefiore Maria R. Napolitano Domenica M. Monque Davide Carlei Paola Mariglia Simona Pauselli Maria Gozzer Mahnaz Shafii Bafti Gabriella Girelli Anna Guarini Filippo Belardelli Robin Foà 《Trasfusione del sangue》2015,13(3):464-471
BackgroundGreat interest has been raised recently by the design of new adoptive immunotherapeutic strategies based on the in vivo infusion of ex vivo-expanded and activated natural killer (NK) cells. The development of good manufacturing practice (GMP) methods for the efficient production of fully functional NK cells is mandatory for clinical application.ResultsNK-cell populations expanded on average 15.7±4.7 fold by day 14, with a viability of 96% ±0.5. At the end of the incubation period, 97% ±1.1 of the expanded population was CD56+ NK cells; these effector cells showed significant up-regulation of the activating receptors NKG2D and DNAM-1. Functional tests demonstrated that expanded NK cells are fully functional with no difference whether tested before cryopreservation or after thawing.DiscussionThese data provide the basis for developing new NK-cell-based immunotherapeutic strategies for the treatment of patients with cancer. 相似文献
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Jhon A. Ochoa-Alvarez Harini Krishnan John G. Pastorino Evan Nevel David Kephart Joseph J. Lee Edward P. Retzbach Yongquan Shen Mahnaz Fatahzadeh Soly Baredes Evelyne Kalyoussef Masaru Honma Martin E. Adelson Mika K. Kaneko Yukinari Kato Mary Ann Young Lisa Deluca-Rapone Alan J. Shienbaum Kingsley Yin Lasse D. Jensen Gary S. Goldberg 《Oncotarget》2015,6(11):9045-9060
Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause most oral cancers. Here, we studied how a monoclonal antibody (NZ-1) and lectin (MASL) that target PDPN affect human OSCC cell motility and viability. Both reagents inhibited the migration of PDPN expressing OSCC cells at nanomolar concentrations before inhibiting cell viability at micromolar concentrations. In addition, both reagents induced mitochondrial membrane permeability transition to kill OSCC cells that express PDPN by caspase independent nonapoptotic necrosis. Furthermore, MASL displayed a surprisingly robust ability to target PDPN on OSCC cells within minutes of exposure, and significantly inhibited human OSCC dissemination in zebrafish embryos. Moreover, we report that human OSCC cells formed tumors that expressed PDPN in mice, and induced PDPN expression in infiltrating host murine cancer associated fibroblasts. Taken together, these data suggest that antibodies and lectins may be utilized to combat OSCC and other cancers that express PDPN. 相似文献
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Pang-yu?Teng Norman?P.?Blair Justin?Wanek Mahnaz?ShahidiEmail author 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2012,250(3):361-367
Background
Oxygen delivery from the retinal vasculature plays a crucial role in maintaining normal retinal metabolic function. Therefore, measurements of retinal vascular oxygen tension (PO2) and PO2 longitudinal gradients (gPO2) along retinal blood vessels may help gain fundamental knowledge of retinal physiology and pathological processes. 相似文献49.
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