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In this paper, the problem of persistent‐bounded disturbance rejection of linear continuous‐time systems with time‐varying delays is investigated using the tools of invariant set analysis and Lyapunov‐function methodology. We derive less conservative sufficient conditions on robust attractor for time‐delay systems in terms of strict linear matrix inequalities (LMIs) to guarantee the desired ??1‐performance. A robust output‐feedback controller is designed and the associated gain is determined using strict LMIs. The developed results are tested on two representative time‐delay examples. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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Magdi Shehata Sunil Bhandari Gopalakrishnan Venkat-Raman Richard Moore Richard D'Souza Hany Riad Ali Bakran Richard Baker Christine Needham Christopher Andrews 《Transplant international》2009,22(8):821-830
Despite the potential tolerability advantage of enteric-coated mycophenolate sodium (EC-MPS), no prospective, randomized trial has evaluated whether conversion from mycophenolate mofetil (MMF) to EC-MPS permits mycophenolic acid dose to be increased or gastrointestinal side-effects to be ameliorated. In a randomized, multicenter, open-label trial, kidney transplant recipients experiencing gastrointestinal side-effects either remained on MMF or switched to an equimolar dose of EC-MPS, adjusted 2 weeks subsequently to target the highest tolerated dose up to 1440 mg/day (EC-MPS) or 2000 mg/day (MMF). Patients were followed up to 12 weeks postrandomization. One hundred and thirty-four patients were randomized. The primary efficacy endpoint, the proportion of patients receiving a higher mycophenolic acid (MPA) dose at week 12 than at randomization, was significantly greater in the EC-MPS arm (32/68, 47.1%) than the MMF arm (10/61, 16.4%; P < 0.001). At the final visit, 50.0% (34/68) of EC-MPS patients were receiving the maximum recommended dose versus 26.2% (16/61) of MMF patients ( P = 0.007). Kidney transplant patients receiving reduced-dose MMF because of gastrointestinal side-effects can tolerate a significant increase in MPA dose after conversion to EC-MPS. Patient-reported gastrointestinal outcomes with higher doses of EC-MPS remained at least as good as in MMF-treated controls. 相似文献
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George RS Birks EJ Radley-Smith RC Khaghani A Yacoub M 《The Annals of thoracic surgery》2007,83(1):306-308
In recent years the conservative techniques to treat degenerative mitral valve insufficiency have developed to such an extent mainly due to a better understanding of the physiology and pathology of the mitral valve and to the possibility to get predictable and satisfactory results. Still a challenge persists for the cardiac surgeon when he has to deal with complex reconstructions. The technique described seems to offer an even better surgical option for patients with complex lesions involving the posterior mitral leaflet, especially as far as the hemodynamic performance is concerned. 相似文献
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Background
Opioid analgesics have proven efficacy in the short-term management of chronic cancer pain, but data on their long-term use is more limited. OROS? hydromorphone is a controlled-release formulation of oral hydromorphone that may be particularly well suited to long-term management of chronic cancer pain because it provides stable plasma concentrations and consistent analgesia with convenient once-daily dosing. The objective of this study (DO-118X) was to characterise the pain control achieved with long-term repeated dosing of OROS? hydromorphone in patients with chronic cancer pain. 相似文献59.
Sanjay Jaju Samir Al-Adawi Hilal Al-Kharusi Magdi Morsi Asya Al-Riyami 《Child and adolescent psychiatry and mental health》2009,3(1):29-11
Background
There is a dearth of studies exploring the magnitude of mental disorders amongst adolescents and youths in the Arab world. To our knowledge, this phase 2 survey in Oman is the first nationally representative school-based study to determine the prevalence of DSM-IV mental disorders (lifetime and over the preceding 12 months), their age-of-onset distributions and determine their severity over the past 12 months using the World Mental Health-Composite International Diagnostic Interview, the WMH-CIDI, used for international comparison. 相似文献60.
Asya A Al Riyami Samir H Al Adawi Hilal A Al Kharusi Magdi M Morsi Sanjay S Jaju 《International journal of mental health systems》2009,3(1):22-11