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941.
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Defa Arisandi MHS RN Makoto Oe PhD RN Rie Roselyne Yotsu PhD MD Masaru Matsumoto PhD RN Kazuhiro Ogai PhD Gojiro Nakagami PhD RN Takeshi Tamaki PhD MD Suriadi PhD RN Hiromi Sanada PhD RN WOCN Junko Sugama PhD RN 《Wound repair and regeneration》2016,24(5):876-884
We developed a new assessment tool for diabetic foot ulcers because no such tool specifically for diabetic foot ulcer exists. The diabetic foot ulcer assessment scale (DFUAS) has 11 domain items. The minimum and maximum scores on this scale are 0 and 98, respectively; higher scores indicate more severe wounds. The aim of this study was to evaluate the concurrent validity, construct validity and predictive validity of DFUAS in Indonesia. A prospective cohort study was conducted on patients with diabetic foot ulcer at Kitamura wound clinic in Indonesia. A total of 62 patients with 70 diabetic foot ulcers were assessed with DFUAS tool, Bates‐Jensen wound assessment tool (BWAT), and pressure ulcer scale for healing (PUSH). Concurrent validity was determined by correlation of the DFUAS total score with the external criterion (BWAT, PUSH, and wound surface area). A comparison between the total DFUAS score and chronic wound status was made to determine construct validity. We also analyzed 41 wounds that were followed for 4 weeks to evaluate predictive validity. The correlation coefficient total scores of the DFUAS against the BWAT, PUSH, and wound surface area were 0.92, 0.87, and 0.82, respectively. The comparison of the total DFUAS score with chronic wound status was p < 0.001. The predictive validity test indicated that a DFUAS cutoff score of 12 produced the best balance of sensitivity, specificity, positive predictive value, and negative predictive value (89%, 71%, 86%, and 77%, respectively). In conclusion, the newly developed DFUAS is a valid tool for assessing diabetic foot ulcers. 相似文献
943.
Automated Functional Imaging by 2D Speckle Tracking Echocardiography Reveals High Incidence of Abnormal Longitudinal Strain in a Cohort of Pediatric Oncology Patients 下载免费PDF全文
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Breast magnetic resonance imaging (MRI) radiogenomics is an emerging area of research that has the potential to directly influence clinical practice. Clinical MRI scanners today are capable of providing excellent temporal and spatial resolution, which allows extraction of numerous imaging features via human extraction approaches or complex computer vision algorithms. Meanwhile, advances in breast cancer genetics research has resulted in the identification of promising genes associated with cancer outcomes. In addition, validated genomic signatures have been developed that allow categorization of breast cancers into distinct molecular subtypes as well as predict the risk of cancer recurrence and response to therapy. Current radiogenomics research has been directed towards exploratory analysis of individual genes, understanding tumor biology, and developing imaging surrogates to genetic analysis with the long‐term goal of developing a meaningful tool for clinical care. The background of breast MRI radiogenomics research, image feature extraction techniques, approaches to radiogenomics research, and promising areas of investigation are reviewed. J. Magn. Reson. Imaging 2016;43:1269–1278. 相似文献
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Dr. Barbara Greenberg MSc PhD Dr. Alan Berkman MD Dr. Rogelio Thomas MD Dr. David Hoos MD Dr. Ruth Finkelstein ScD Ms. Jacquie Astemborski MHS Drs. David Vlahov PhD 《Journal of urban health》1999,76(4):468-480
Objective To examine response to highly active antiretroviral therapy (HAART) among a sample of treatment-experienced patients in the
late stage of human immunodeficiency virus (HIV) infection in residential health care facilities (RHCFs) in New York City
facilities designated for HIV/AIDS (acquired immunodeficiency syndrome) when access and adherence are maximized.
Methods Medical record review of 111 patients.
Results Demographics were mean age 42 years; 58% male; 60% African-American; 31% Hispanic; 57% injection drug users (IDUs); 23% with
history of dementia; 52% hepatitis C virus (HCV) antibody seropositive; 80% on HAART, of whom 18% had lipodystrophy. Of 88
patients on HAART, 52% had a decreased viral load (>1/2log) versus 13% of 23 not on HAART (P<.05); a>1/2log viral load increase was seen in 8% and 35%, respectively (P<.05). Those with viral load increase were more likely than those with stable/decreased viral load to be IDUs (71% vs. 64%)
and to have HCV seropositivity (86% vs. 53%), even with similar initial CD4+ cell count, viral load, and follow-up time.
Conclusion In a predominantly minority IDU population who are treatment experienced, 50% of the patients successfully responded to treatment
with supervised therapy. The RHCFs in New York City provide a unique opportunity to examine further factors associated with
response to HAART in an environment in which medication administration and adherence are maximized and monitored carefully.
Dr. Berkman is from Columbia University/Highbridge Woodycrest Residential Health Care Facility.
Ms. Astemborski is from the Johns Hopkins School of Hygiene and Public Health.
Supported by the New York Academy of Medicine. 相似文献
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Longitudinal analysis of quality‐of‐life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial 下载免费PDF全文
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Long‐term psychological and educational outcomes for survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study 下载免费PDF全文
Daniel J. Zheng MD MHS Kevin R. Krull PhD Yan Chen MMath Lisa Diller MD Yutaka Yasui PhD Wendy Leisenring ScD Pim Brouwers PhD Rebecca Howell PhD Jin‐Shei Lai PhD Lyn Balsamo PhD Kevin C. Oeffinger MD Leslie L. Robison PhD Gregory T. Armstrong MD MSCE Nina S. Kadan‐Lottick MD MSPH 《Cancer》2018,124(15):3220-3230