全文获取类型
收费全文 | 137808篇 |
免费 | 13152篇 |
国内免费 | 10320篇 |
专业分类
耳鼻咽喉 | 1170篇 |
儿科学 | 1359篇 |
妇产科学 | 1248篇 |
基础医学 | 15132篇 |
口腔科学 | 2451篇 |
临床医学 | 18342篇 |
内科学 | 19066篇 |
皮肤病学 | 1382篇 |
神经病学 | 6645篇 |
特种医学 | 5194篇 |
外国民族医学 | 78篇 |
外科学 | 13544篇 |
综合类 | 26597篇 |
现状与发展 | 45篇 |
一般理论 | 6篇 |
预防医学 | 10356篇 |
眼科学 | 3546篇 |
药学 | 14840篇 |
127篇 | |
中国医学 | 9469篇 |
肿瘤学 | 10683篇 |
出版年
2024年 | 571篇 |
2023年 | 2313篇 |
2022年 | 5796篇 |
2021年 | 7256篇 |
2020年 | 5568篇 |
2019年 | 4407篇 |
2018年 | 4599篇 |
2017年 | 4303篇 |
2016年 | 3996篇 |
2015年 | 6250篇 |
2014年 | 7693篇 |
2013年 | 7274篇 |
2012年 | 10534篇 |
2011年 | 11466篇 |
2010年 | 7928篇 |
2009年 | 6305篇 |
2008年 | 7697篇 |
2007年 | 7528篇 |
2006年 | 7161篇 |
2005年 | 6861篇 |
2004年 | 4524篇 |
2003年 | 4090篇 |
2002年 | 3445篇 |
2001年 | 3055篇 |
2000年 | 3073篇 |
1999年 | 3082篇 |
1998年 | 2007篇 |
1997年 | 2041篇 |
1996年 | 1571篇 |
1995年 | 1479篇 |
1994年 | 1288篇 |
1993年 | 798篇 |
1992年 | 990篇 |
1991年 | 802篇 |
1990年 | 669篇 |
1989年 | 628篇 |
1988年 | 524篇 |
1987年 | 461篇 |
1986年 | 403篇 |
1985年 | 301篇 |
1984年 | 136篇 |
1983年 | 120篇 |
1982年 | 70篇 |
1981年 | 72篇 |
1980年 | 47篇 |
1979年 | 55篇 |
1959年 | 4篇 |
1958年 | 12篇 |
1957年 | 5篇 |
1955年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 11 毫秒
961.
Xu Yangyang He Qi Wang Mengqi Gao Yuan Liu Xiaowei Li Denghui Xiong Botao Wang Wei 《Neurosurgical review》2021,44(1):115-127
Neurosurgical Review - Magnetic resonance imaging-guided focused ultrasound (MRgFUS) neurosurgery is a new option for medication-resistant Parkinson’s disease (PD), but its safety and... 相似文献
962.
目的探讨多西他赛+卡铂联合曲妥珠单抗(TCH)方案对早期人表皮生长因子受体2(HER2)阳性乳腺癌的新辅助治疗效果。方法回顾性分析2013年1月至2018年12月北京大学第一医院乳腺疾病中心经治的522例早期HER2阳性乳腺癌患者的临床资料,占同期收治早期浸润性乳腺癌患者的21.80%(522/2 394)。其中113例接受TCH方案进行新辅助治疗,年龄[M(QR)]52(13)岁(范围:23~69岁)。记录TCH方案新辅助治疗后病理完全缓解(pCR,ypT0N0M0期)的例数,采用Miller-Payne标准进行病理学评价。采用Kaplan-Meier法计算无病生存率和总体生存率,采用Log-rank检验比较组间生存差异。结果接受曲妥珠单抗规范治疗患者(294例)的无病生存率优于未规范治疗患者(177例)(84.4%比72.4%,χ2=4.095,P=0.046)。发生3~4级不良反应的患者占全部患者的15.9%(18/113),包括3~4级中性粒细胞减少12例,腹泻6例。31例患者获得pCR(ypT0N0M0),pCR率为27.4%(31/113)。pCR患者与非pCR患者的无病生存率和总体生存率无差异(91.8%比85.0%,92.5%比90.5%,P值均>0.05)。病理学评价为G4~5的患者无病生存率优于G1~3患者(89.6%比81.5%,χ2=5.340,P=0.021),而总体生存率的差异无统计学意义(91.4%比89.1%,χ2=1.008,P=0.315)。结论早期HER2阳性乳腺癌采用TCH方案行新辅助治疗的效果较好,新辅助治疗后病理学评价为G4~5的患者的无病生存率更高。 相似文献
963.
964.
BackgroundDespite the importance of diversity in advancing scientific progress, diversity among leading authors in arthroplasty has not been examined. This study aimed to identify, characterize, and assess disparities among leading authors in arthroplasty literature from 2002 to 2019.MethodsArticles published between 2002 and 2019 from 12 academic journals that publish orthopedic and arthroplasty research were extracted from PubMed. Original articles containing keywords related to arthroplasty were analyzed. Author gender was assigned using the Genderize algorithm. Gender and characterization of the top 100 male and female authors utilized available information on academic profiles.ResultsFrom the 14,692 articles that met inclusion criteria, the genders of 23,626 unique authors were identified. Women were less likely than men to publish 5 years after beginning their publishing careers (adjusted odds ratio 0.51, 95% confidence interval 0.45-0.57, P < .001). Of the top 100 authors, 96 were men, while only 4 were women. Orthopedic surgeons made up 93 of 100 top authors, of which 92 were men and 1 was a woman. Among the top 10 publishing female and male authors, 10 of 10 men were orthopedic surgeons, only 2 of 10 women were physicians, and only one was an attending orthopedic surgeon.ConclusionWhile the majority of authors with high arthroplasty publication volume were orthopedic surgeons, there were significant gender disparities among the leading researchers. We should continue working to increase gender representation and supporting the research careers of women in arthroplasty. 相似文献
965.
Zichen Hao Jun Li Bo Li Kareme D Alder Sean V Cahill Alana M Munger Inkyu Lee Hyuk-Kwon Kwon JungHo Back Shuogui Xu Min-Jong Kang Francis Y Lee 《Journal of bone and mineral research》2021,36(1):186-198
Smokers are at a higher risk of delayed union or nonunion after fracture repair. Few specific interventions are available for prevention because the molecular mechanisms that result in these negative sequelae are poorly understood. Murine models that mimic fracture healing in smokers are crucial in further understanding the local cellular and molecular alterations during fracture healing caused by smoking. We exposed three murine strains, C57BL/6J, 129X1/SvJ, and BALB/cJ, to cigarette smoke for 3 months before the induction of a midshaft transverse femoral osteotomy. We evaluated fracture healing 4 weeks after the osteotomy using radiography, micro-computed tomography (μCT), and biomechanical testing. Radiographic analysis demonstrated a significant decrease in the fracture healing capacity of smoking 129X1/SvJ mice. μCT results showed delayed remodeling of fracture calluses in all three strains after cigarette smoke exposure. Biomechanical testing indicated the most significant impairment in the functional properties of 129X1/SvJ in comparison with C57BL/6J and BALB/cJ mice after cigarette smoke exposure. Thus, the 129X1/SvJ strain is most suitable in simulating smoking-induced impaired fracture healing. Furthermore, in smoking 129X1/SvJ murine models, we investigated the molecular and cellular alterations in fracture healing caused by cigarette smoking using histology, flow cytometry, and multiplex cytokine/chemokine analysis. Histological analysis showed impaired chondrogenesis in cigarette smoking. In addition, the important reparative cell populations, including skeletal stem cells and their downstream progenitors, demonstrated decreased expansion after injury as a result of cigarette smoking. Moreover, significantly increased pro-inflammatory mediators and the recruitment of immune cells in fracture hematomas were demonstrated in smoking mice. Collectively, our findings demonstrate the significant cellular and molecular alterations during fracture healing impaired by smoking, including disrupted chondrogenesis, aberrant skeletal stem and progenitor cell activity, and a pronounced initial inflammatory response. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献
966.
Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice
967.
Honghong Ren Lijun Zhao Yutong Zou Yiting Wang Junlin Zhang Yucheng Wu Rui Zhang Tingli Wang Jiali Wang Yitao Zhu Ruikun Guo Huan Xu Lin Li Mark E. Cooper Fang Liu 《Renal failure》2021,43(1):477
AimsChronic kidney disease (CKD) and diabetes mellitus increase atherosclerotic cardiovascular diseases (ASCVD) risk. However, the association between renal outcome of diabetic kidney disease (DKD) and ASCVD risk is unclear.MethodsThis retrospective study enrolled 218 type 2 diabetic patients with biopsy-proven DKD, and without known cardiovascular diseases. Baseline characteristics were obtained and the 10-year ASCVD risk score was calculated using the Pooled Cohort Equation (PCE). Renal outcome was defined as progression to end-stage renal disease (ESRD). The association between ASCVD risk and renal function and outcome was analyzed with logistic regression and Cox analysis.ResultsAmong all patients, the median 10-year ASCVD risk score was 14.1%. The median of ASCVD risk score in CKD stage 1, 2, 3, and 4 was 10.9%, 12.3%, 16.5%, and 14.8%, respectively (p = 0.268). Compared with patients with lower ASCVD risk (<14.1%), those with higher ASCVD risk had lower eGFR, higher systolic blood pressure, and more severe renal interstitial inflammation. High ASCVD risk (>14.1%) was an independent indicator of renal dysfunction in multivariable-adjusted logistic analysis (OR, 3.997; 95%CI, 1.385–11.530; p = 0.010), though failed to be an independent risk factor for ESRD in patients with DKD in univariate and multivariate Cox analysis.ConclusionsDKD patients even in CKD stage 1 had comparable ASCVD risk score to patients in CKD stage 2, 3, and 4. Higher ASCVD risk indicated severe renal insufficiency, while no prognostic value of ASVCD risk for renal outcome was observed, which implied macroangiopathy and microangiopathy in patients with DKD were related, but relatively independent. 相似文献
968.
Feng Zhang Yingmei Wang Yuying Wang Xinli Wang Dawei Zhang Xiong Zhao Runmin Jiang Yu Gu Guifang Yang Xin Fu Longyong Xu Longxia Xu Liting Zheng Jing Zhang Zengshan Li Qingguo Yan Jianguo Shi Albert Roessner Zhe Wang Qing Li Jing Ye Charlie Degui Chen Shuangping Guo Jie Min 《Journal of bone and mineral research》2021,36(10):1931-1941
969.
970.
Tong Chen Jianglong Chen Qingfeng Sheng Linlin Zhu Xiaoling Bai Weijue Xu Jiangbin Liu Xiaoyan Li Zhibao Lv 《Journal of pediatric surgery》2021,56(4):800-804
BackgroundPyriform sinus fistula (PSF) is a rare congenital anomaly, and the preferred definitive treatment is yet to be verified. In this study, we investigated the treatment outcomes of PSF specifically comparing endoscopic-assisted surgery and endoscopic radiofrequency ablation (RA).MethodsThe medical records of patients treated for PSF at the Shanghai Children's Hospital between October 2016 and September 2019 were retrospectively evaluated.ResultsThere were 93 girls and 98 boys. The median age at onset and operation was 3 years and 5 years, respectively. Endoscopic-assisted surgery was performed in 143 patients. During the same period, RA was performed in 48 patients, and 10 of them concurrently underwent incision and drainage of neck abscesses. Longer hospital stay was found in the endoscopic-assisted surgery group than in the RA group (10.50 ± 3.93 vs. 5.02 ± 3.30 days, P < 0.001). Postoperative complications were not significantly different between the two groups, except for neck infection (0 vs. 8.3%, P = 0.004). After a median follow-up period of 21 months, no significant difference was found between the two groups in terms of recurrence (1.4% vs. 0, P = 0.560).ConclusionPatients treated with RA had a significantly shorter hospital stay than those treated with endoscopic-assisted surgery. Outcomes of endoscopic-assisted surgery and RA were not significantly different for the management of PSF and treatment method should be tailored to the patient.Level of evidenceIV. 相似文献