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排序方式: 共有285条查询结果,搜索用时 15 毫秒
111.
MAURIZIO LUNATI PASCAL DEFAYE† JOHANN MERMI‡ ARCADI GARCIA-ALBEROLA§ JOSÉ L. MERINO ANGEL ARENAL¶ RICCARDO CAPPATO# XAVIER NAVARRO MICAELA PASSARDI†† MASSIMO SANTINI‡‡ 《Pacing and clinical electrophysiology : PACE》2006,29(S2):S35-S39
Background: Implantable cardioverter-defibrillators (ICD) can terminate ventricular tachyarrhythmias with shocks (painful) or antitachycardia pacing (painless). According to the results of the Pacing Fast VT Reduces Shock ThErapies Trials, antitachycardia pacing (ATP) can avoid painful shocks and also increase device longevity. The purpose of the ADVANCE-D (Atp DeliVery for PAiNless ICD ThErapy) study is to determine the most appropriate ventricular tachycardia (VT) therapy, so as to optimize painless therapy for life-threatening arrhythmias.
Methods and Results: The ADVANCE-D is a prospective, multicenter, parallel, two-arm randomized study designed to evaluate the efficacy of two different sequences of ATP therapies (burst 15 pulses, 88%, vs burst 8 pulses, 88%), during an episode of spontaneous arrhythmia classified as fast VT (FVT) in patients with a Class I or IIA indication for ICD implantation (single and dual chamber devices). The primary endpoint is to compare the efficacy of two ATP therapies for FVT episodes. The study will enroll a minimum of 900 patients within 2 years, followed-up for 12 months. The investigation is expected to be completed in 2007.
Conclusions: The ADVANCE-D trial is the first large randomized clinical investigation aimed to evaluate optimal programming and efficacy of ATP. 相似文献
Methods and Results: The ADVANCE-D is a prospective, multicenter, parallel, two-arm randomized study designed to evaluate the efficacy of two different sequences of ATP therapies (burst 15 pulses, 88%, vs burst 8 pulses, 88%), during an episode of spontaneous arrhythmia classified as fast VT (FVT) in patients with a Class I or IIA indication for ICD implantation (single and dual chamber devices). The primary endpoint is to compare the efficacy of two ATP therapies for FVT episodes. The study will enroll a minimum of 900 patients within 2 years, followed-up for 12 months. The investigation is expected to be completed in 2007.
Conclusions: The ADVANCE-D trial is the first large randomized clinical investigation aimed to evaluate optimal programming and efficacy of ATP. 相似文献
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CLAUDIO COSTANTINO NICOLE BONACCORSO MARTINA SCIORTINO LUCIANO DAZZO ALESSANDRO CARUBIA DANIELA CHIFARI DANIELA SEGRETO DONATELLA MARCHESE FABRIZIO RUSSO MARIO MINORE ALESSIA PIERI GIORGIO GRAZIANO CARMELO MASSIMO MAIDA VINCENZO RESTIVO FABIO TRAMUTO FRANCESCO VITALE WALTER MAZZUCCO 《Journal of preventive medicine and hygiene》2022,63(3):E399
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Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial 总被引:3,自引:0,他引:3
DAVIDSON R. N.; MARTINO L. DI; GRADONI L.; GIACCHINO R.; RUSSO R.; GAETA G. B.; PEMPINELLO R.; SCOTT S.; RAIMONDI F.; CASCIO A.; PRESTILEO T.; CALDEIRA L.; WILKINSON R. J.; BRYCESON A. D. M. 《QJM : monthly journal of the Association of Physicians》1994,87(2):75-81
Thirty-one patients with visceral leishmaniasis (VL) causedby Leishmania infantum received liposomal amphotericin B (AmBisome)in a multi-centre study. Ten immunocompetent patients (six children)received 11.38 mg/kg/day for 21 days, and ten (nine children)received 3 mg/kg/day for 10 days. All were cured without significantadverse events and without relapse during 1224 monthsof follow-up. Eleven immunocompromised adults, including sevenco-infected with HIV (four with AIDS) received 100mg (1.381.85mg/kg) daily for 21 days. All were initially considered cured,but eight relapsed clinically and parasitologically at 322months. Liposomal amphotericin B is a new, safe and effectivedrug for the treatment of VL. 相似文献
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ABSTRACT— The transport of cholic acid (CA) and chenodeoxycholic acid (CDC) and their influence on bile formation was investigated in rats treated with bromobenzene (BZ), a toxicant which selectively destroys zone 3 of the hepatic acinus. The necrosis equals 27–31% of the acinus cells. The absence of zone 3 in rats reduced the secretory rate maximum of CA and CDC by 18% (NS) and 25% (p<0.05), respectively. The maximum bile flow was not different from control during CA infusion but was lower during CDC infusion in BZ-treated animals. Although the bile acid concentration was lower in BZ-treated rats, only values obtained during the basal period and the beginning of the infusion reached the level of statistically significant difference. The bile salt-independent flow (BSIF) was not affected by the absence of zone 3. Our data suggest that zones 1 and 2 of the hepatic acinus can compensate for the secretion of CA and elaboration of BSIF when zone 3 is destroyed. However, necrosis of zone 3 reduces CDC secretion. Thus, the capacity for bile acid transport of the hepatocytes of different zones in the hepatic acinus may differ according to the circulating bile acid. 相似文献
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ERMINIA M. GUARNERI M.D. ROBERT J. RUSSO M.D. FRANKLIN ZALMAN M.D. NANCY B. MORRIS R.N. PAUL S. TEIRSTEIN M.D. 《Journal of interventional cardiology》1996,9(6):459-462
A 62-year-old man sustained an anterior wall myocardial infarction 7 years following coronary artery bypass graft surgery. The patient underwent successful placement of a Palmaz-Schatz stent within the ostium of the left internal mammary artery utilizing ultrasound guidance and was discharged in 24 hours with reduced anticoagulation . 相似文献