Clinical use of tramal in patients in the early postoperative period

Tramal was given to 204 patients who were operated on the lung, heart, abdomen. During pain therapy, good and satisfactory results were on average obtained in 75% patients operated on the lung, in 77%, on the heart, in 89%, on the abdomen, in 70%, on the great vessels. The absence of the inhibitory effect of the drug on the respiratory center and its slightly marked sedative effect allow one to recommend the agent for application in the early period following the surgery when narcotic analgesics still retain their effect and a real risk of their overdosage exists. During prolonged artificial pulmonary ventilation in the early postoperative period and in impaired adaptation of the patients to a respirator, tramal aids normalization of lung mechanics and hemodynamic parameters without eliminating and suppressing the patients' consciousness and results in cessation of muscular shivering. Adverse effects of tramal are of no decisive clinical significance and occur mainly when the drug is rapidly injected into the vein.     

Effect of chronic prostatitis on the endocrine activity of the testes]

It was shown in experiments on rabbits that androgenopoiesis was disturbed in the testes under conditions of aseptic chronic inflammation of the prostate: against the background of a sharp reduction of testosterone and androstendion formation there was observed production and discharge into the blood of great amounts of progesterone, this being not characteristic of the incretory activity of the intact gonads. It is suggested that the search for the ways of steroidogenesis restoration in the testes under conditions of induced pathology should be directed to the activation of enzymes catalyzing the processes of progesterone transformation into 17-alpha-hydroxyprogesteron, androstendion, and testosterone.