全文获取类型
收费全文 | 1163篇 |
免费 | 202篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 49篇 |
妇产科学 | 12篇 |
基础医学 | 92篇 |
口腔科学 | 12篇 |
临床医学 | 230篇 |
内科学 | 310篇 |
皮肤病学 | 32篇 |
神经病学 | 62篇 |
特种医学 | 81篇 |
外科学 | 223篇 |
综合类 | 56篇 |
现状与发展 | 20篇 |
一般理论 | 1篇 |
预防医学 | 80篇 |
眼科学 | 27篇 |
药学 | 32篇 |
中国医学 | 2篇 |
肿瘤学 | 50篇 |
出版年
2024年 | 7篇 |
2023年 | 42篇 |
2021年 | 22篇 |
2020年 | 25篇 |
2019年 | 13篇 |
2018年 | 51篇 |
2017年 | 45篇 |
2016年 | 33篇 |
2015年 | 47篇 |
2014年 | 47篇 |
2013年 | 64篇 |
2012年 | 32篇 |
2011年 | 43篇 |
2010年 | 56篇 |
2009年 | 70篇 |
2008年 | 46篇 |
2007年 | 34篇 |
2006年 | 41篇 |
2005年 | 22篇 |
2004年 | 18篇 |
2003年 | 20篇 |
2002年 | 29篇 |
2001年 | 26篇 |
2000年 | 26篇 |
1999年 | 26篇 |
1998年 | 36篇 |
1997年 | 40篇 |
1996年 | 44篇 |
1995年 | 31篇 |
1994年 | 19篇 |
1993年 | 26篇 |
1992年 | 12篇 |
1991年 | 16篇 |
1990年 | 16篇 |
1989年 | 18篇 |
1988年 | 21篇 |
1987年 | 23篇 |
1986年 | 19篇 |
1985年 | 23篇 |
1984年 | 7篇 |
1983年 | 11篇 |
1982年 | 11篇 |
1981年 | 13篇 |
1980年 | 7篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1976年 | 11篇 |
1975年 | 8篇 |
1971年 | 6篇 |
1960年 | 6篇 |
排序方式: 共有1383条查询结果,搜索用时 15 毫秒
81.
82.
Background
Anxiety and depression co-occur in children and adolescents with anxiety commonly preceding depression. Although there is some evidence to suggest that the association between early anxiety and later depression is explained by a shared genetic aetiology, the contribution of environmental factors is less well examined and it is unknown whether anxiety itself is a phenotypic risk factor for later depression. These explanations of the association between early anxiety and later depression were evaluated. 相似文献83.
Nishtar S Wierzbicki AS Lumb PJ Lambert-Hammill M Turner CN Crook MA Mattu MA Shahab S Badar A Ehsan A Marber MS Gill J 《Current medical research and opinion》2004,20(1):55-62
OBJECTIVE: To establish risk factor causal associations for coronary artery disease (CAD) in the native Pakistani population. METHODS: We conducted a hospital-based, case-control study of 200 cases with angiographically documented CAD and 200 age- and sex-matched controls without angiographic evidence of CAD. Patients on lipid lowering therapy were excluded. Lifestyle, anthropometric and biochemical risk factors were assessed in both groups. RESULTS: The presence of CAD was associated with current, past or passive smoking, a history of diabetes and high blood pressure, a positive family risk factors in this study; levels were below history of CAD, body fat percentage, waist-hip ratio (WHR), low apolipoprotein A1 or low HDL, lipoprotein (a), glucose, insulin, insulin resistance, C-reactive protein (CRP), total cholesterol to HDL ratio (TC/HDL) and creatinine on univariate conditional logistic regression analysis. In multiple regression analysis, significant independent associations were found with low HDL (OR 0.11; 95% CI 0.04-0.34; p < 0.001) positive family history (OR 1.79; 95% CI 1.09-2.93; p = 0.02), CRP (OR 1.45; 95% CI 1.19-1.75; p < 0.001) and WHR (OR 1.04; 95% CI 1.01-1.08; p = 0.01). Angiograms were also quantified for the extent and severity of CAD by the Gensini scoring system. Quantitative angiographic data showed associations with age (p = 0.01), the duration of diabetes (p = 0.04), WHR (p = 0.06), low HDL (p < 0.001), lipoprotein (a) (p = 0.001), creatinine (p < 0.001) and CRP (p = 0.007). Results indicate that total and LDL cholesterol were not significant currently accepted thresholds for treatment. CONCLUSIONS: The cardiovascular risk profile in this population is consistent with metabolic syndrome where low HDL and WHR can be used to predict the risk of CAD. Results suggest the need to redefine the currently practised approach to CAD management in this population to fit local needs. 相似文献
84.
OBJECTIVES: To compare the relative importance of social, academic and application form factors at admission in predicting performance in the first 3 years of a medicine course. DESIGN: Retrospective cohort study. SETTING: A single UK medical school. PARTICIPANTS: A total of 738 students who entered medical school between 1994 and 1997. MAIN OUTCOME MEASURE: Performance in Year 3 objective structured clinical examination (OSCE). RESULTS: School-leaving grades were significant predictors of success in the OSCE. Non-academic activities as assessed from the application form were associated with poorer performance. Mature students performed extremely well, and male and ethnic minority students performed less well. Socioeconomic status and type of school attended were not found to affect performance on the course. CONCLUSIONS: The relatively poor performance of male and ethnic minority students urgently needs further investigation. Our results carry no suggestion that, other things being equal, widening access to medical school for mature students and those from less affluent backgrounds would result in poorer performance. 相似文献
85.
New aspects of ventilation in acute lung injury 总被引:8,自引:0,他引:8
Recent recognition that artificial ventilation may cause damage to the acutely injured lung has caused renewed interest in ventilation techniques that minimise this potential harm. Many ventilation techniques have proved beneficial in small trials of very specific patient groups, but most have subsequently failed to translate into improved patient outcome in larger trials. An exception to this is 'protective ventilation' using reduced tidal volumes (to lower airway pressure) and increased PEEP (to reduce pulmonary collapse). Results of trials of protective ventilation have been encouraging, and the technique should now be adopted more widely. High frequency ventilation, inverse ratio ventilation, prone positioning and inhaled nitric oxide are all techniques that may be considered when, in spite of optimal artificial ventilation, the patient's gas exchange remains dangerously poor. Under these circumstances, the choice of technique is dependent on their availability, local expertise and individual patient needs. 相似文献
86.
The clinical and biochemical determinants of the fibrinogen response to simvastatin or atorvastatin therapy were assessed in 130 patients with severe polygenic or familial hypercholesterolemia treated in a randomized open-trial format design. Hyperfibrinogenemia was associated with atorvastatin, baseline fibrinogen, and initial concentration and change in concentration of apolipoprotein B or low-density lipoprotein cholesterol. 相似文献
87.
88.
Wierzbicki AS Lambert-Hammill M Junadi E Lumb PJ Crook MA 《Journal of cardiovascular risk》2000,7(6):431-434
BACKGROUND: Plasma homocysteine and the methylene tetrahydrofolate reductase C677T polymorphism have been suggested as being risk factors for cardiovascular disease. OBJECTIVE: To determine whether plasma homocysteine and the methylene tetrahydrofolate reductase C677T polymorphism are risk factors for coronary heart disease in patients with heterozygous familial hypercholesterolaemia as compared with those with polygenic hyperlipidaemia. METHODS: Plasma homocysteine and the methylene tetrahydrofolate reductase polymorphism were assessed with other risk factors in 112 patients with familial hypercholesterolaemia and 72 patients with polygenic hyperlipidaemia, of whom 29 (25.8%) and 30 (41%) respectively had established cardiovascular disease and in 100 healthy normal subjects. RESULTS: Plasma homocysteine was not significantly elevated in patients with and without coronary heart disease with familial hypercholesterolaemia or polygenic hyperlipidaemia compared with controls. The allele frequencies for C677T were significantly different in patients with coronary heart disease and with polygenic hyperlipidaemia (0.35 versus 0.29) (P = 0.02) as opposed to those with coronary heart disease and familial hypercholesterolaemia (0.25 versus 0.30) (P = 0.63). Methylene tetrahydrofolate reductase genotype but not homocysteine had a weak association with coronary heart disease in logistic regression analysis in patients with polygenic hyperlipidaemia (P = 0.05) but neither methylene tetrahydrofolate reductase genotype or plasma homocysteine was a risk factor in patients with familial hypercholesterolaemia. CONCLUSION: Whilst methylene tetrahydrofolate reductase genotype may be a weak risk factor for coronary heart disease in polygenic hyperlipidaemia as opposed to familial hypercholesterolaemia, homocysteine does not seem to be an important risk factor for coronary heart disease in patients in southern UK. 相似文献
89.
90.