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71.
O’Grady Aiden Welsh Luke Gibson Matthew Briggs James Speirs Archie Little Mark 《Cardiovascular and interventional radiology》2022,45(1):80-90
CardioVascular and Interventional Radiology - Genicular artery embolisation (GAE) is a novel treatment for patients with knee osteoarthritis (OA). Cadaveric dissection was undertaken to provide a... 相似文献
72.
Pamidronate results in symptom control of hypertrophic pulmonary osteoarthropathy in cystic fibrosis 总被引:4,自引:0,他引:4
Hypertrophic pulmonary osteoarthropathy (HPOA) may complicate the advanced lung disease that is associated with cystic fibrosis, resulting in severe joint pain and early-morning stiffness. Symptoms are usually controlled with the administration of nonsteroidal anti-inflammatory drugs, physiotherapy, and, on occasions, oral corticosteroids. This report describes a case of refractory HPOA with complete remission following the administration of IV pamidronate, which is a potent inhibitor of osteoclastic bone resorption. Symptom relief resulted for up to 3 months, but repeated courses of pamidronate have been required to maintain symptom control. 相似文献
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74.
Brian Cox James Duffy Victor Zdorichenko Corentin Bellanger Jessica Hurcum Benoît Laleu Kevin I. Booker-Milburn Luke D. Elliott Michael Robertson-Ralph Christopher J. Swain Stephen J. Bishop Irene Hallyburton Mark Anderson 《ACS medicinal chemistry letters》2020,11(12):2497
We utilized synthetic photochemistry to generate novel sp3-rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane scaffold. Preliminary antimalarial screening of the library provided promising compounds with activity in the 1–5 μM range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality. 相似文献
75.
Jelle Veraart Erika P. Raven Luke J. Edwards Nikolaus Weiskopf Derek K. Jones 《Human brain mapping》2021,42(7):2201
The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non‐invasive mapping of micron‐sized axon radii using commonly applied neuroimaging techniques, that is, diffusion‐weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter‐ and intra‐scanner test–retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient‐of‐variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test–retest analysis, but it is shown that the performance can be improved fourfold using a customized along‐tract analysis. 相似文献
76.
Luke Eason Josh Mason Rachel Cooper Ganesh Radhakrishna Peter Bownes 《Brachytherapy》2021,20(2):393-400
PurposeTG43 does not account for a lack of scatter and tissue and applicator heterogeneities. The advanced collapsed-cone engine (ACE) algorithm available for use in the Oncentra Brachy treatment planning system (Elekta AB, Stockholm, Sweden) can model these conditions more accurately and is evaluated for esophageal and surface mold brachytherapy treatments.Methods and MaterialsACE was commissioned for use then compared against TG43 for five esophageal and five surface mold treatment plans. Dosimetric differences between each algorithm were assessed using superimposed comparisons and dose-volume histogram statistics.ResultsEsophagus (6 Gy per fraction): Compared with TG43, ACE demonstrated up to a 0.63% and 0.05 Gy reduction in planning target volume (PTV) V100% and PTV D98, respectively. Lung D2cc and bone D2cc deviated by up to 0.09 Gy and 0.03 Gy, respectively. Lung D0.1 cc and bone D0.1 cc both deviated by up to 0.12 Gy.Surface mold (4.5 Gy per fraction): Compared with TG43, ACE demonstrated up to a 12.5% and 0.18 Gy reduction in PTV V80% and PTV D98, respectively. Bone D2cc and D0.1 cc both reduced by up to 0.2 Gy when modeled with ACE. Increasing mold size laterally increased the dosimetric differences between TG43 and ACE.ConclusionsTG43 generally overestimated dose delivered to the target volume and organs at risk for the sites investigated. Dosimetric differences observed for esophageal treatments were minimal; however, surface mold treatments would benefit from the increased dosimetric accuracy offered by ACE.Implementation should be considered for surface mold 192Ir treatment planning, but increased calculation time, additional contouring, and mass density assignment requirements should be scrutinized with regard to their potentially negative impact on current clinical practice. 相似文献
77.
Johnson Sonia Dalton-Locke Christian Vera San Juan Norha Foye Una Oram Sian Papamichail Alexandra Landau Sabine Rowan Olive Rachel Jeynes Tamar Shah Prisha Sheridan Rains Luke Lloyd-Evans Brynmor Carr Sarah Killaspy Helen Gillard Steve Simpson Alan 《Social psychiatry and psychiatric epidemiology》2021,56(1):25-37
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79.
Carroll Sarah L. Clark D. Angus Hyde Luke W. Klump Kelly L. Burt S. Alexandra 《Behavior genetics》2021,51(5):580-591
Behavior Genetics - Trajectories of youth antisocial behavior (ASB) are characterized by both continuity and change. Twin studies have further indicated that genetic factors underlie continuity,... 相似文献
80.
William M. Adams Samantha E. Scarneo-Miller Lesley W. Vandermark Luke N. Belval Lindsay J. DiStefano Elaine C. Lee Lawrence E. Armstrong Douglas J. Casa 《Journal of Athletic Training》2021,56(2):203
ContextHypohydration has been shown to alter neuromuscular function. However, the longevity of these impairments remains unclear.ObjectiveTo examine the effects of graded exercise-induced dehydration on neuromuscular control 24 hours after exercise-induced hypohydration.DesignCrossover study.SettingLaboratory.Patients or Other ParticipantsA total of 23 men (age = 21 ± 2 years, height = 179.8 ± 6.4 cm, mass = 75.24 ± 7.93 kg, maximal oxygen uptake [VO2max] = 51.7 ± 5.5 mL·kg−1·min−1, body fat = 14.2% ± 4.6%).Intervention(s)Participants completed 3 randomized exercise trials: euhydrated arrival plus fluid replacement (EUR), euhydrated arrival plus no fluid (EUD), and hypohydrated arrival plus no fluid (HYD) in hot conditions (ambient temperature = 35.2°C ± 0.6°C, relative humidity = 31.3% ± 2.5%). Each trial consisted of 180 minutes of exercise (six 30-minute cycles: 8 minutes at 40% VO2max; 8 minutes, 60% VO2max; 8 minutes, 40% VO2max; 6 minutes, passive rest) followed by 60 minutes of passive recovery.Main Outcome Measure(s)We used the Landing Error Scoring System and Balance Error Scoring System (BESS) to measure movement technique and postural control at pre-exercise, postexercise and passive rest (POSTEX), and 24 hours postexercise (POST24). Differences were assessed using separate mixed-design (trial × time) repeated-measures analyses of variance.ResultsThe magnitude of hypohydration at POSTEX was different among EUR, EUD, and HYD trials (0.2% ± 1%, 3.5% ± 1%, and 5% ± 0.9%, respectively; P < .05). We observed no differences in Landing Error Scoring System scores at pre-exercise (2.9 ± 1.6, 3.0 ± 2.1, 3.0 ± 2.0), POSTEX (3.3 ± 1.5, 3.0 ± 2.0, 3.1 ± 1.9), or POST24 (3.3 ± 1.9, 3.2 ± 1.4, 3.3 ± 1.6) among the EUD, EUR, and HYD trials, respectively (P = .90). Hydration status did not affect BESS scores (P = .11), but BESS scores at POSTEX (10.4 ± 1.1) were greater than at POST24 (7.7 ± 0.9; P = .03).ConclusionsWhereas exercise-induced dehydration up to 5% body mass did not impair movement technique or postural control 24 hours after a prolonged bout of exercise in a hot environment, postural control was impaired at 60 minutes after prolonged exercise in the heat. Consideration of the length of recovery time between bouts of exercise in hot environments is warranted. 相似文献