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991.
992.
993.
Three hours after iv administration of alloxan and 5,6-diamino-2,4-dihydroxy-pyrimidine to mice infected with chloroquine-sensitive (CS) and chloroquine-resistant (CR) strains of Plasmodium berghei, the 2 compounds showed remarkable antimalarial actions. Parasitemia in CS and CR infected mice were reduced by about 50%. Slight hemolysis was seen in mice treated with alloxan but not in mice treated with 5,6-diamino-2,4-dihydro-pyrimidine. Alloxan did not inhibit glutathione reductase activity and no alloxan-glutathione complex was produced. No relationship between the antimalarial effects of alloxan and hemolysis or GSH content were found. It is suggested that the antimalarial effects of the two agents may be due to the inhibition of dihydroorotic acid dehydrogenase. 相似文献
994.
995.
In this paper, 34 samples, 25 from 18 cervical carcinoma patients and 9 from 8 non-cervical carcinoma patients, were assayed using (alpha-32P) dCTP HSV-2 DNA probe and nucleic acid hybridization technic. It was shown that the positive rates of HSV-2 DNA corresponding sequence were 50% (2/4), 36% (5/14) and 12% (1/8) in the in situ cancer, invasive cancer and non-cervical cancer tissues. No HSV was isolated from 7 cancer specimens which showed a positive reaction by nucleic acid hybridization. 相似文献
996.
997.
998.
999.
K L Davis L E Hollister A A Mathé B M Davis A B Rothpearl K F Faull J Y Hsieh J D Barchas P A Berger 《The American journal of psychiatry》1981,138(12):1555-1562
The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patients were DST positive and 33% had a blunted TSH response. Two biologic variables, the 8 a.m. postdexamethasone cortisol and the postprobenecid CSF 5-hydroxyindoleacetic acid (5-HIAA), accounted for over half of the variance in the behavioral measure, the Hamilton score. Plasma cortisol elevation was associated with high 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion; TSH blunting was associated with low urinary MHPG excretion. Comprehensive biologic measures showed certain significant interrelationships and correlations with the severity of depression. 相似文献
1000.
Zhou Zhong-yuan周中源 Zhao Wei-bin赵蔚斌 Fu Xin-xiang傅信祥Shanghai Fourth People''s Hospital Shanghai 《中华医学杂志(英文版)》1987,100(2):118-121
Plasma testosterone and estradiol are determined
in 72 patients with abnormal high density lipoprotein.
cholesterol (HDL-C) and high density lipoprotein
cholesterol/total cholesterol (H/T) ratio values, and
in 72 randomly chosen males with normal HDLC
and H/T values. The results showed that plasma
testosterone levels in the groups with abnormal
HDL-C and H/T were obviously lower than those
in the controls. Statistically significant differences
were found in all the abnormal groups in comparison
with the controls (P0.20).
Testosterone levels lowered further with increasing
age in the groups with abnormal HDL-C and H/T.,
the most obvious drops were in the groups around
56 years of age (P<0.005). The data indicate that
male hormone deficiency may reduce HDL-C and
H.'T and facilitate the process of atherosclero_is.
Therefore, it seems rational to treat such patients
with male sex hormone preparations or to use the
traditional Chinese medicines which strengthen Yang
(maleness) in a new attempt to treat and prevent
CHD. 相似文献