溶栓颗粒对缺血再灌注损伤大鼠IL-1β及MMP-9的影响

目的:探讨溶栓颗粒对大鼠全脑缺血再灌注损伤的脑保护作用。方法:用四动脉夹闭(4VO)所致大鼠急性全脑缺血再灌注模型,放免法和免疫组化法分别检测血清IL-1β及脑组织MMP-9。结果:缺血再灌注损伤可造成大鼠血清IL-1β及脑组织MMP-9的高表达。中药组IL-1β及MMP-9的表达较少。结论:溶栓颗粒可以保护缺血再灌注大鼠受损伤脑组织,并可能通过减少血清IL-1β和脑组织MMP-9的途径实现。     

男性生殖器疣中人乳头瘤病毒基因分型研究进展

人乳头瘤病毒(HPV)感染是全球最常见的性传播疾病(STD)之一。近年来研究证实HPV感染与男性生殖器疣和恶性肿瘤同样具有密切关系。本文就男性HPV感染的近况以及HPV的基因分型在男性生殖器疣中的研究进展作一综述。     

Attitudes and perceptions regarding skin cancer and sun protection behaviour in an Irish population

BACKGROUND: Although people seem to be well educated on the harmful effects of the sun, they continue to intentionally expose themselves without adequate protection. AIMS: To ascertain baseline knowledge regarding skin cancer and review the sun protection behaviours in an Irish population and the effect of doctor-based education on these behaviours. METHODS: Two hundred participants were recruited for a questionnaire-based study on their perceptions regarding skin cancer and their sun protection behaviour. They were divided into two groups, with one group receiving doctor-based education following the initial survey, and a follow-up questionnaire was carried out within 3 months. RESULTS: Ninety per cent of participants knew that sun exposure was the major risk factor for skin cancer, and 95% knew that sun beds were not a safe way to tan. Despite this, < 20% used regular sunscreen, and 30% had used or were currently using sun beds in order to tan. CONCLUSION: Our study indicated that although the participants' knowledge of skin cancer and risk of sun exposure is high, their sun-protective attitudes were not influenced by education in the clinical setting.     

The effects of severe growth hormone deficiency on the skin of patients with Sheehan''s syndrome

BACKGROUND: Growth hormone (GH) may play an important role in the content and appearance of the skin. Dry, thin and pale skin has been described in hypopituitarism. Sheehan's syndrome is characterized by anterior pituitary dysfunction due to postpartum pituitary necrosis and GH is one of the hormones lost first. OBJECTIVE: The aim of this study was to examine the hydration of the skin of patients with Sheehan's syndrome using measurements of capacitance, sebum content, transepidermal water loss, pH and temperature. The data were compared with those of control subjects. METHODS: A total of 21 patients with Sheehan's syndrome and 20 women as control subjects were included in this blinded prospective study. Hormone deficiencies other than GH had been adequately replaced. The diagnosis of GH deficiency (GHD) was established by the insulin tolerance test (ITT). Skin properties were measured by non-invasive and well-established methods. RESULTS: The skin capacitance had decreased on the forehead and forearm and sebum content had decreased on the forehead of patients with Sheehan's syndrome when compared with control subjects. The pH, temperature and average transepidermal water loss (TEWL) of the skin of the patients were not statistically different from the controls. CONCLUSION: GHD results in a decrease in skin capacitance and sebum content indicating that GH and/or insulin-like growth factor-I (IGF-I) have an important role in skin function.