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51.
Antônio P. R. Filho Camila B. do Nascimento Luciana P. G. d’Arce 《International journal of environmental health research》2018,28(1):1-7
Gas station attendants are potentially exposed to carcinogenic substances. This study aimed to evaluate chronic occupational exposed gas station attendant’s according to genetic parameters and its relationship with cancer predisposition. Forty gas station attendants were recruited and paired with 40 control subjects. Thousand cells from each subject were analyzed counting the number of pyknotic (PYC), karyolitic (KYL), karyorrhetic (KHC), condensed chromatin (CC), binucleated (BN), basal cells (BC), Nuclear buds (Nbud), and differentiated cells (DIFF). More 2.000 differentiated cells were analyzed counting micronucleated (MNi) and nuclear buds (NBud). We observed a statistical increase in BC and decrease in DIFF (p < 0.05). PYC, CC, KYL, MN, NBud were statistically increased (p < 0.05). All in all, our data showed elevated DNA damage, chromosomal instability, and cell cycle disturbing in our group of gas station attendants. It is a clear risk for their health in future and could be classified as a cancer predisposition. 相似文献
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Alice Song Edson Abdala Daniel Waisberg Rodrigo Bronze Martino Ho Yeh Li Luiz Marcelo Sa Malbouisson Ryan Yukimatsu Tanigawa Amaro Duarte Neto Guilherme Marques Andrade Liliana Ducatti Andre Mario Doi João Renato Rebello Pinho Michele Gomes‐Gouvea Fernanda Malta Lecio Figueira Pinto Bruno Fukelmann Guedes Luciana Haddad Venancio Avancini F. Alves Luiz Augusto D. Albuquerque 《The Brazilian journal of infectious diseases》2018
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How brain processes translate into creativity is still an unsolved puzzle in science. 相似文献
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Evaluating Communication Skills of Geriatrics Fellows: Interrater Agreement of an Objective Structured Clinical Examination 下载免费PDF全文
Marcos Daniel Saraiva MD Maria Luiza de Melo Paulo MD Thiago Junqueira Avelino‐Silva MD Luiz Antonio Gil‐Junior MD Elina Lika Kikuchi MD Luciana Louzada Farias MD Rafael Lyra Rodrigues Alves MD Gisele Sayuri Suzuki MD Fábio Cesar Olivieri MD Valmari Cristina Aranha MSc Leonardo da Costa Lopes MD PhD Maria Cristina Guerra Passarelli MD PhD Julio Cesar Moriguti MD PhD Eduardo Ferrioli MD PhD Chao Lung Wen MD PhD Daniel Apolinário MD PhD Wilson Jacob‐Filho MD PhD 《Journal of the American Geriatrics Society》2016,64(1):206-207
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Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion 下载免费PDF全文
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Luciana C. de Oliveira Margareth Z. Gomes Marcus L. Brandão 《International journal of developmental neuroscience》2011,29(1):77-83
Studies have revealed that the extent of reactivity of high-anxiety rats to diverse challenges is different than low-anxiety rats and have provided important insights into the psychopathology of anxiety. Various factors intervene to allow defensive mechanisms to react to diverse threatening challenges, including ontogeny and the nature of the emotional challenge (e.g., conditioned vs. unconditioned). The present study investigated the extent to which a particular type of fear extrapolates to other emotional responses to diverse threatening challenges. Groups of 30- and 60-day-old rats were assigned to low freezing behavior (LFB) and high freezing behavior (HFB) groups using the contextual fear conditioning paradigm and subjected to either the fear-potentiated startle (FPS) test, novelty-induced ultrasound vocalizations (USVs) or elevated plus-maze (EPM) tests. At 30 days of age, HFB rats exhibited greater FPS than LFB rats. In contrast, prior selection of HFB and LFB did not affect the performance of 30-day-old animals in the EPM and novelty-induced USVs. Sixty-day-old animals exhibited a performance deficit in all three tests. These data suggest that the performance of young rats in animal models of anxiety parallels their selection as LFB and HFB in the contextual fear conditioning paradigm. However, the increased fear-like behavior exhibited by the 60-day-old HFB rats may elicit performance deficits in conditioned and unconditioned fear tests. These results suggest that the interaction between hyperanxiety and age may cause a performance deficit despite the animals’ increased fear-like behavior when facing emotional challenges, thus resembling psychiatric patients in many respects. 相似文献
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