全文获取类型
收费全文 | 30909篇 |
免费 | 2862篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 395篇 |
儿科学 | 1177篇 |
妇产科学 | 836篇 |
基础医学 | 4452篇 |
口腔科学 | 501篇 |
临床医学 | 4142篇 |
内科学 | 5873篇 |
皮肤病学 | 360篇 |
神经病学 | 2676篇 |
特种医学 | 930篇 |
外国民族医学 | 5篇 |
外科学 | 3318篇 |
综合类 | 645篇 |
一般理论 | 43篇 |
预防医学 | 3904篇 |
眼科学 | 434篇 |
药学 | 2157篇 |
1篇 | |
中国医学 | 14篇 |
肿瘤学 | 1955篇 |
出版年
2023年 | 203篇 |
2022年 | 256篇 |
2021年 | 634篇 |
2020年 | 431篇 |
2019年 | 691篇 |
2018年 | 713篇 |
2017年 | 569篇 |
2016年 | 568篇 |
2015年 | 660篇 |
2014年 | 888篇 |
2013年 | 1316篇 |
2012年 | 1779篇 |
2011年 | 1855篇 |
2010年 | 1004篇 |
2009年 | 846篇 |
2008年 | 1499篇 |
2007年 | 1591篇 |
2006年 | 1511篇 |
2005年 | 1429篇 |
2004年 | 1335篇 |
2003年 | 1221篇 |
2002年 | 1198篇 |
2001年 | 688篇 |
2000年 | 686篇 |
1999年 | 584篇 |
1998年 | 344篇 |
1997年 | 264篇 |
1996年 | 289篇 |
1995年 | 271篇 |
1994年 | 242篇 |
1993年 | 210篇 |
1992年 | 525篇 |
1991年 | 526篇 |
1990年 | 478篇 |
1989年 | 444篇 |
1988年 | 416篇 |
1987年 | 434篇 |
1986年 | 429篇 |
1985年 | 429篇 |
1984年 | 335篇 |
1983年 | 282篇 |
1982年 | 226篇 |
1981年 | 185篇 |
1979年 | 316篇 |
1978年 | 235篇 |
1977年 | 213篇 |
1976年 | 185篇 |
1975年 | 184篇 |
1974年 | 190篇 |
1973年 | 198篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
S M Hall 《Journal of the Royal Society of Medicine》1986,79(10):596-598
32.
33.
The routine manual encoding of pathological data, using the SNOP and SNOMED systems at two London teaching hospitals, was reviewed. The error rates in the two departments were compared and the causes analysed. The relative merits of SNOP and SNOMED were considered. Methods to optimise the efficiency of manual encoding are suggested and the importance of accuracy in coding is emphasised. 相似文献
34.
35.
Jens O L J?rgensen Louise M?ller Morten Krag Nils Billestrup Jens S Christiansen 《Endocrinology & Metabolism Clinics of North America》2007,36(1):75-87
This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored. 相似文献
36.
37.
38.
Claire-Jehanne Dubouloz Diane Laporte Martha Hall Brenda Ashe C Douglas Smith 《The American journal of occupational therapy》2004,58(4):398-407
The purpose of this qualitative study was to examine the process of transformation of personal beliefs, values, feelings, and knowledge (meaning perspectives) underlying occupational change in a small group of clients with rheumatoid arthritis during home-based rehabilitation. A grounded theory approach used to collect and analyze data concurrently included: (1) a sample of five adult clients diagnosed with rheumatoid arthritis in occupational therapy, (2) data collection through 28 semi-directed interviews, and (3) data analysis using the constant comparison method. The study identified meaning perspectives of these clients with rheumatoid arthritis and explored the transformation of perspectives related to the modification of occupational performance. The study suggests that the exploration of meaning perspective transformation by clients and therapists could be a potential part of rehabilitation intervention. 相似文献
39.
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer. 总被引:3,自引:0,他引:3
Amit Shah William A Swain Donna Richardson John Edwards Duncan J Stewart Catherine M Richardson Daniel E B Swinson Dipika Patel J Louise Jones Kenneth J O'Byrne 《Clinical cancer research》2005,11(8):2930-2936
Akt, a Serine/Threonine protein kinase, mediates growth factor-associated cell survival. Constitutive activation of Akt (phosphorylated Akt, P-Akt) has been observed in several human cancers, including lung cancer and may be associated with poor prognosis and chemotherapy and radiotherapy resistance. The clinical relevance of P-Akt in non-small cell lung cancer (NSCLC) is not well described. In the present study, we examined 82 surgically resected snap-frozen and paraffin-embedded stage I to IIIA NSCLC samples for P-Akt and Akt by Western blotting and for P-Akt by immunohistochemistry. P-Akt protein levels above the median, measured using reproducible semiquantitative band densitometry, correlated with a favorable outcome (P = 0.007). Multivariate analysis identified P-Akt as a significant independent favorable prognostic factor (P = 0.004). Although associated with a favorable prognosis, high P-Akt levels correlated with high tumor grade (P = 0.02). Adenocarcinomas were associated with low P-Akt levels (P = 0.039). Akt was not associated with either outcome or clinicopathologic variables.Cytoplasmic (CP-Akt) and nuclear (NP-Akt) P-Akt tumor cell staining was detected in 96% and 42% of cases, respectively. Both CP-Akt and NP-Akt correlated with well-differentiated tumors (P = 0.008 and 0.017, respectively). NP-Akt also correlated with nodal metastases (P = 0.022) and squamous histology (P = 0.037).These results suggest P-Akt expression is a favorable prognostic factor in NSCLC. Immunolocalization of P-Akt, however, may be relevant as NP-Akt was associated with nodal metastases, a known poor prognostic feature in this disease. P-Akt may be a potential novel therapeutic target for the management of NSCLC. 相似文献
40.
A series of 5-alkyl-5-phenylbarbituric acid analogues were shown to be potent hypolipidemic agents in rats and mice at 20 mg/kg/day. This dose is lower than that required for hypolipidemic activity for clofibrate and nicotinic acid derivatives in rodents and man. These new derivatives reduced both serum cholesterol and triglyceride levels in rodents by either the oral or intraperitoneal route of administration. Previous studies have demonstrated that similar heterocyclic compounds, i.e. cyclic imides, glutarimides and hydantoins are potent hypolipidemic agents in rodents. The barbituric acid derivatives probably interfered with de novo synthesis of cholesterol and fatty acids in the early steps since the agents inhibit the activities of ATP-dependent citrate lyase and acetyl-CoA synthetase. Triglyceride synthesis may be blocked since the agents inhibited the rate limiting enzyme, sn-glycerol-3-phosphate-acyl-transferase. Rat tissue lipids especially cholesterol and triglycerides were reduced after 14 days treatment. Fecal lipids were increased in cholesterol and phospholipid content by selected compounds. The rat serum lipoprotein after 14 days drug administration showed reduced VLDL-cholesterol and HDL-triglyceride contents. The modulation of the lipid content of the serum lipoproteins by the barbituric acids suggest that these agents may be helpful in treating clinical hyperlipidemic disease states. 相似文献