全文获取类型
收费全文 | 99782篇 |
免费 | 7249篇 |
国内免费 | 302篇 |
专业分类
耳鼻咽喉 | 1289篇 |
儿科学 | 2751篇 |
妇产科学 | 2616篇 |
基础医学 | 16035篇 |
口腔科学 | 2499篇 |
临床医学 | 9128篇 |
内科学 | 20274篇 |
皮肤病学 | 1709篇 |
神经病学 | 9217篇 |
特种医学 | 4032篇 |
外国民族医学 | 49篇 |
外科学 | 13048篇 |
综合类 | 900篇 |
一般理论 | 93篇 |
预防医学 | 8107篇 |
眼科学 | 1737篇 |
药学 | 6799篇 |
1篇 | |
中国医学 | 262篇 |
肿瘤学 | 6787篇 |
出版年
2022年 | 773篇 |
2021年 | 1831篇 |
2020年 | 1119篇 |
2019年 | 1596篇 |
2018年 | 2029篇 |
2017年 | 1456篇 |
2016年 | 1685篇 |
2015年 | 1981篇 |
2014年 | 2489篇 |
2013年 | 3860篇 |
2012年 | 5391篇 |
2011年 | 5645篇 |
2010年 | 3522篇 |
2009年 | 3120篇 |
2008年 | 4861篇 |
2007年 | 5124篇 |
2006年 | 4895篇 |
2005年 | 4791篇 |
2004年 | 4608篇 |
2003年 | 4272篇 |
2002年 | 4087篇 |
2001年 | 3271篇 |
2000年 | 3371篇 |
1999年 | 2966篇 |
1998年 | 1239篇 |
1997年 | 1062篇 |
1996年 | 950篇 |
1995年 | 927篇 |
1994年 | 798篇 |
1993年 | 827篇 |
1992年 | 1964篇 |
1991年 | 1859篇 |
1990年 | 1781篇 |
1989年 | 1769篇 |
1988年 | 1432篇 |
1987年 | 1442篇 |
1986年 | 1333篇 |
1985年 | 1219篇 |
1984年 | 900篇 |
1983年 | 811篇 |
1982年 | 554篇 |
1981年 | 550篇 |
1980年 | 463篇 |
1979年 | 751篇 |
1978年 | 450篇 |
1977年 | 423篇 |
1975年 | 449篇 |
1974年 | 511篇 |
1973年 | 417篇 |
1972年 | 419篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
131.
Hilde Tobi Paul B. van den Berg Lolkje TW de Jong‐van den Berg 《Pharmacoepidemiology and drug safety》2006,15(3):211-211
The original article to which this Erratum refers was published in Pharmacoepidemiology and Drug Safety 2005; 14: 239–247. 相似文献
132.
Prospective multicenter clinical trial of Uretex Sup for surgical treatment of stress urinary incontinence 总被引:1,自引:0,他引:1
Ariane Cortesse Bernard Jacquetin Philippe Grise Loïc Le Normand François Richard François Haab 《International journal of urology》2007,14(7):611-615
AIM: To evaluate in a prospective multicenter study the efficacy and safety of the suburethral support Uretex (Sofradim, Trevoux, France) delivered by a suprapubic approach in the treatment of female stress urinary incontinence. METHODS: Between March 2002 and March 2003, 57 patients were treated for stress urinary incontinence with Uretex. Preoperative evaluation included urodynamic examination and questionnaires (symptoms and quality of life, Contilife). Forty patients had pure stress urinary incontinence and 17 mixed urinary incontinence. No associated procedure was performed. The objective cure rate was evaluated by clinical examination and pad-test, and the subjective cure rate was assessed through questionnaires at 1, 3 and 12 months. RESULTS: The mean follow-up was 13 months (range 11-24 months). During follow up, chronic urinary retention requiring a tape section occurred in one patient, and in another patient a delay of vaginal healing was followed by a sling exposure and resection at 4 months. No infection or urethral erosion was reported. The objective cure rate was 96.2%, and the subjective cure rate was 79.2%; four patients reported low leakage on stress and nine patients complained of urge incontinence (four de novo and five persistent). CONCLUSION: The suprapubic Uretex Sup procedure is a safe and effective treatment for women with stress urinary incontinence. 相似文献
133.
134.
In France, general practitioners (GPs) express difficulties in exercise of home palliative care. Those difficulties are described in various studies but none assesses the multidisciplinary collaboration’s impact. In the present study (2005–2008), 291 GPs included in a palliative care network responded to a questionnaire. Results showed the benefits of this partnership organization. Detailed analysis of 36 collaboration cases clarified the reasons for these difficulties and the network influence. 相似文献
135.
136.
B L Van Duuren 《Environmental research》1989,49(2):143-151
The alpha-chloroether carcinogen chloromethylmethyl ether (CME) and its impurity bis(chloromethyl)ether (BCME) are direct-acting alkylating agents. Vinyl chloride (VC) is an indirect-acting carcinogen but its accepted carcinogenic intermediate, chloroethylene oxide, is also an alpha-chloroether. Both CME-BCME and VC have been in industrial use since about 1950. Hence, they were selected for comparison of potency as human carcinogens using numerous epidemiologic reports. There were 115 deaths due to angiosarcoma of the liver among several hundred thousand VC-exposed workers on the basis of reports from 10 countries during 1955 and 1984. Reports from five countries cited a total of 87 respiratory cancer deaths among only 3024 CME-BCME-exposed workers. If a recent court settlement in the United States is taken into account, the number of respiratory cancer deaths due to CME-BCME rises to 117. On the basis of these numbers of cancer deaths, and the levels and durations of exposure, it is concluded that VC is a weak human carcinogen compared to CME-BCME. 相似文献
137.
G R Westerman J B Norton E A Kiel S H Van Devanter 《The Annals of thoracic surgery》1987,44(2):154-158
Double-outlet right ventricle and severe systemic outflow tract hypoplasia comprises a subset of patients in whom total correction or palliation requires complex surgical procedures in the neonatal period. Our experience with 3 patients illustrates the difficulties associated with treatment and suggests possible surgical options for this otherwise lethal variant of the Taussig-Bing syndrome. 相似文献
138.
V B Van Hasselt L A Sisson S R Aach 《Journal of behavior therapy and experimental psychiatry》1987,18(3):275-283
A training program was implemented to modify a mother's behavior management skills to improve compliance in her 4-year-old child who suffered from severe developmental and physical disabilities. A multiple baseline analysis indicated that behavioral intervention was effective in training the mother to make definitive commands, provide appropriate positive attention, and persist with commands during social interactions with her child. In addition, substantial improvement in the child's compliance with mother's commands followed introduction of parent training. Further, positive collateral effects included the child's increased time on-task and decreased oppositional behavior. All gains were maintained at a 6-month follow-up probe. 相似文献
139.
Patients with complaints of halitosis do seek treatment from physicians and dental practitioners, because of the fear that their halitosis may interfere with their social activities. Although the prevalence of halitosis has been reported to be as high as 50%, most physicians and dental practitioners are poorly informed about the causes and treatments of halitosis. In order to care for patients with complaints of halitosis a multidisciplinary team was established at the Erasmus Medical Centre, Rotterdam, The Netherlands. The team included a dental hygienist, an otorhinolaryngologist, and a dentist, who developed a special halitosis programme. One short press release regarding the establishment of the team, was provided to the national press-centre. In the out-patient clinic more than 700 patients were seen by the team. Using a structured questionnaire fed to a PC, patients answered questions regarding complaints about the oral cavity, the upper respiratory tract, the throat, their general health, their cleansing habits of the oral cavity, and prior experiences with general physicians, dental practitioners, and medical specialists. They underwent examinations of the extent of their halitosis, of the perioral and neck region, the oral cavity, the upper respiratory tract, and the upper digestive tract. Finally, the members of the team came to a joint diagnosis and a joint treatment plan for every individual patient. Of the first 700 consecutive patients around 90% had a natural dentition without removable partial dentures. More than 60% were diagnosed as having periodontal disease with pockets of 4 mm or more in the maxilla. This figure was more than 50% in the mandible. Around 95% had tongue coating. 相似文献
140.
The use of a new hydrophilic polymer, Kollicoat IR, in the formulation of solid dispersions of Itraconazole. 总被引:1,自引:0,他引:1
Sandrien Janssens Hector Novoa de Armas Jean Paul Remon Guy Van den Mooter 《European journal of pharmaceutical sciences》2007,30(3-4):288-294
Kollicoat IR, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of Itraconazole. The solid dispersions were prepared by hot stage extrusion. Modulated temperature differential scanning calorimetry and X-ray powder diffraction were used to evaluate the miscibility of the drug and the carrier. The pharmaceutical performance was evaluated by dissolution experiments, performed in simulated gastric fluid without pepsin (SGF(sp)). In the X-ray diffractograms no Itraconazole peaks were visible; the polymer on the other hand appeared to be semi-crystalline. Moreover, its crystallinity increased during the extrusion process due to exposure to heat and shear forces. Modulated temperature differential scanning calorimetry analysis showed that the drug and the polymer formed a two phase system. Separate clusters of glassy Itraconazole were present for drug loads of 40% or higher, indicating further phase separation. Dissolution measurements demonstrated a significantly increased dissolution rate for the solid dispersions compared to physical mixtures. Interestingly the physical mixture made up of glassy Itraconazole and Kollicoat IR (20/80, w/w) showed a dissolution rate and maximum that was much higher than that of the physical mixture made up of crystalline Itraconazole and that of pure glassy Itraconazole. The results of this study show that Kollicoat IR is a promising excipient for the formulation of solid dispersions of Itraconazole prepared by hot stage extrusion. 相似文献