全文获取类型
收费全文 | 331篇 |
免费 | 14篇 |
国内免费 | 14篇 |
专业分类
儿科学 | 15篇 |
妇产科学 | 7篇 |
基础医学 | 31篇 |
口腔科学 | 13篇 |
临床医学 | 26篇 |
内科学 | 74篇 |
皮肤病学 | 5篇 |
神经病学 | 4篇 |
特种医学 | 126篇 |
外科学 | 22篇 |
综合类 | 7篇 |
预防医学 | 8篇 |
眼科学 | 2篇 |
药学 | 11篇 |
肿瘤学 | 8篇 |
出版年
2021年 | 1篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 7篇 |
2014年 | 4篇 |
2013年 | 6篇 |
2012年 | 4篇 |
2011年 | 5篇 |
2010年 | 5篇 |
2009年 | 15篇 |
2008年 | 6篇 |
2007年 | 10篇 |
2006年 | 6篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 3篇 |
2002年 | 1篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 19篇 |
1997年 | 23篇 |
1996年 | 22篇 |
1995年 | 10篇 |
1994年 | 16篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 1篇 |
1990年 | 6篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 14篇 |
1984年 | 5篇 |
1983年 | 17篇 |
1982年 | 17篇 |
1981年 | 15篇 |
1980年 | 10篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 11篇 |
1976年 | 6篇 |
1975年 | 1篇 |
排序方式: 共有359条查询结果,搜索用时 0 毫秒
101.
Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1 总被引:3,自引:0,他引:3
van der Maarel SM; Scholten IH; Huber I; Philippe C; Suijkerbuijk RF; Gilgenkrantz S; Kere J; Cremers FP; Ropers HH 《Human molecular genetics》1996,5(7):887-897
In several families with non-specific X-linked mental retardation (XLMR)
linkage analyses have assigned the underlying gene defect to the
pericentromeric region of the X chromosome, but none of these genes have
been isolated so far. Here, we report on the cloning and characterization
of a novel gene, DXS6673E, that maps to Xq13.1, is subject to
X-inactivation and is disrupted in the 5' untranslated region by a balanced
X;13 translocation in a mentally retarded female. The DXS6673E gene is
highly conserved among vertebrates and its expression is most abundant in
brain. It encodes a hydrophilic protein of 1358 amino acids (aa) that does
not show sequence homology to other known proteins. A segment of this
protein consisting of neutral and hydrophobic aa with a proline residue in
every second position may represent a transmembrane domain. Almost complete
sequence identity was found between the 3' end of the DXS6673E gene and two
expressed sequence tags (ESTs) and between the 5' end of the DXS6673E gene
and a third EST. Moreover, weaker sequence similarity was observed between
coding regions and two other ESTs.
相似文献
102.
Effect of maternal age and conditions of fertilization on programmed cell death during murine preimplantation embryo development 总被引:3,自引:3,他引:3
Jurisicova A; Rogers I; Fasciani A; Casper RF; Varmuza S 《Molecular human reproduction》1998,4(2):139-145
One of the major morphological anomalies observed in many human pre-
embryos is extensive cellular fragmentation. Previously we confirmed that
embryo fragmentation seemed to be associated with the activation of
programmed cell death (PCD). The purpose of our experiments was to
establish a rate for murine embryo fragmentation in vivo after hormonal
stimulation in young versus older females and to compare it with the rate
of embryo fragmentation during in-vitro fertilization (IVF). While murine
maternal age beyond 40 weeks increased the rate of embryo fragmentation
following in-vivo fertilization (P = 0.001), oocytes from females of all
ages had a uniformly high rate of fragmentation when fertilized in vitro
(33%). None of the fragmented murine embryos proceeded further in
development. In the mouse, fragmentation occurs exclusively during the
first cell cycle. Furthermore, IVF significantly reduced the rate of
blastocyst formation (P = 0.0001) and decreased the mean cell number at the
blastocyst stage in comparison with embryos produced in vivo (P <
0.0001). The cell death index was significantly affected by both maternal
age (P = 0.005) and IVF (P = 0.0001). Identification of specific factors
which trigger PCD, especially those associated with IVF, may enable us to
lower the rates of fragmentation in preimplantation embryos and thereby
increase pregnancy rates after human IVF.
相似文献
103.
104.
OS Ogah RO Akinyemi JO Adesina JKL Osinfade RF Ogundipe GD Adegbite OI Udofia SB Udoh OS Ojo AA Alabi T Majekodunmi AO Falase 《Cardiovascular journal of Africa》2011,22(6):297-302
Background
We sought to determine the prevalence of echocardiographically determined left ventricular systolic dysfunction in asymptomatic hypertensive subjects seen in Abeokuta, Nigeria.Methods
Echocardiography was performed in 832 consecutive hypertensive subjects referred for cardiac evaluation over a three-year period.Results
Data were obtained in 832 subjects (50.1% women) aged 56.0 ± 12.7 years (men 56.9 ± 13.3 years, women 55.0 ± 12.0 years, range 15–88). The prevalence of left ventricular systolic dysfunction (LVSD) was 18.1% in the study population (mild LVSD = 9.6%, moderate LVSD = 3.7% and severe LVSD = 4.8%). In a multivariate analysis, male gender, body mass index and LV mass were the predictors of LVSD.Conclusion
Significant numbers of hypertensive subjects in this study had varying degrees of left ventricular systolic dysfunction. Early introduction of disease-modifying drugs in these patients, such as angiotensin converting enzyme inhibitors or angiotensin receptor blockers may retard or prevent the progression to overt heart failure. 相似文献105.
106.
107.
Low intensity laser therapy in the treatment of temporomandibular disorders: a double-blind study 总被引:3,自引:0,他引:3
This study aimed to evaluate the effectiveness of low intensity laser therapy (LILT) in 30 patients presenting temporomandibular joint (TMJ) pain and mandibular dysfunction in a random and double-blind research design. The sample, divided into experimental group (1) and placebo group (2), was submitted to the treatment with infrared laser (780 nm, 30 mW, 10 s, 6.3 J/cm(2)) at three TMJ points. The treatment was evaluated throughout six sessions and 15, 30 and 60 days after the end of the therapy, through visual analogue scale (VAS), range of mandibular movements and TMJ pressure pain threshold. The results showed a reduction in VAS (p < 0.001) and through the ANOVA with repeated measures it was observed that the groups did not present statistically significant differences (P = 0.2060), as the averages of the evaluation times (P = 0.3955) and the interaction groups evaluation times (P = 0.3024), considering the MVO. The same occurred for RLE (P = 0.2988, P = 0.1762 and P = 0.7970), LLE (P = 0.3265, P = 0.4143 and P = 0.0696), PPTD (P = 0.1558, P = 0.4695 and P = 0.0737) and PPTE (P = 0.2376, P = 0.3203 and P = 0.0624). For PE, there were not statistically significant differences for groups (P = 0.7017) and the interaction groups evaluation times (P = 0.6678), even so in both groups the PE varied with time (P = 0.0069). 相似文献
108.
109.
110.