全文获取类型
收费全文 | 34908篇 |
免费 | 2044篇 |
国内免费 | 103篇 |
专业分类
耳鼻咽喉 | 264篇 |
儿科学 | 1243篇 |
妇产科学 | 969篇 |
基础医学 | 3843篇 |
口腔科学 | 417篇 |
临床医学 | 6126篇 |
内科学 | 5645篇 |
皮肤病学 | 361篇 |
神经病学 | 3361篇 |
特种医学 | 755篇 |
外国民族医学 | 1篇 |
外科学 | 3378篇 |
综合类 | 326篇 |
现状与发展 | 1篇 |
一般理论 | 50篇 |
预防医学 | 4719篇 |
眼科学 | 1265篇 |
药学 | 1946篇 |
中国医学 | 33篇 |
肿瘤学 | 2352篇 |
出版年
2023年 | 205篇 |
2022年 | 337篇 |
2021年 | 633篇 |
2020年 | 446篇 |
2019年 | 705篇 |
2018年 | 850篇 |
2017年 | 605篇 |
2016年 | 668篇 |
2015年 | 719篇 |
2014年 | 1043篇 |
2013年 | 1700篇 |
2012年 | 2431篇 |
2011年 | 2594篇 |
2010年 | 1358篇 |
2009年 | 1203篇 |
2008年 | 2302篇 |
2007年 | 2509篇 |
2006年 | 2422篇 |
2005年 | 2361篇 |
2004年 | 2174篇 |
2003年 | 2074篇 |
2002年 | 1983篇 |
2001年 | 331篇 |
2000年 | 301篇 |
1999年 | 349篇 |
1998年 | 401篇 |
1997年 | 329篇 |
1996年 | 273篇 |
1995年 | 291篇 |
1994年 | 234篇 |
1993年 | 233篇 |
1992年 | 206篇 |
1991年 | 207篇 |
1990年 | 190篇 |
1989年 | 171篇 |
1988年 | 155篇 |
1987年 | 159篇 |
1986年 | 146篇 |
1985年 | 169篇 |
1984年 | 177篇 |
1983年 | 156篇 |
1982年 | 174篇 |
1981年 | 161篇 |
1980年 | 145篇 |
1979年 | 97篇 |
1978年 | 105篇 |
1977年 | 90篇 |
1976年 | 68篇 |
1975年 | 59篇 |
1974年 | 62篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
HYPOTHESIS: Irrigation of the mastoid with a quinolone antibiotic-steroid solution may mitigate hearing loss caused by iatrogenic semicircular canal injury in the presence of Pseudomonas aeruginosa (PA) otitis media (OM). BACKGROUND: Studies have shown the cochlea to be more vulnerable to semicircular canal transection (SCT)-related hearing loss in the presence of PA OM. Prophylactic systemic antibiotics and steroids may decrease this hearing loss, but SCT is usually not planned. The aim of this study was to determine if irrigation with ciprofloxacin-dexamethasone (cipro-dex) could improve hearing outcomes following SCT in PA OM. METHODS: PA OM was induced in 28 animals. After three to five days, unilateral SCT was performed in each animal, with sham SCT on the contralateral ear. At surgery, half of the animals (n = 14) underwent irrigation of the both mastoid bullae with cipro-dex; the second group of animals (n = 14) underwent irrigation of the bullae with sterile saline. Auditory thresholds were obtained immediately prior to SCT and 7-10 days after SCT. RESULTS: SCT ears treated with cipro-dex showed a mean click threshold improvement of 4.6 dB from pre-transection to 7-10 days post-transection, whereas thresholds in the SCT ears treated with saline worsened by 7.5 dB (p = 0.15). CONCLUSION: Irrigation of the guinea pig bulla with cipro-dex following SCT in the setting of PA OM appears safe and may yield beneficial effects on hearing. 相似文献
42.
43.
44.
Bibhuti B Das Linda B Pauliks Ole A Knudson Scott Kirby Kak-Chen Chan Lilliam Valdes-Cruz Raul O Cayre 《Journal of the American Society of Echocardiography》2005,18(3):231-236
We identified 18 patients with double-orifice mitral valve (DOMV) and intact atrioventricular (AV) septum out of 40,179 echocardiographic studies performed between 1997 and 2002 at Children's Hospital, Denver, CO. In this study we describe (1) the anatomic characteristics of the DOMV in the absence of AV septal defect, (2) the function of the mitral valve by spectral and color Doppler flow mapping, and (3) associated lesions. The topographic location of the orifices in the leaflets suggests possible embryologic mechanisms of DOMV. In this series, DOMV was most commonly associated with left-sided obstructive lesions (in 39% of patients). Spectral and color Doppler interrogation demonstrated a normal flow profile in most cases; only 2 patients had significant mitral regurgitation or stenosis. Therefore, due to the uncertain natural history of this lesion and the potential need for endocarditis prophylaxis, careful imaging of the mitral valve is recommended, particularly in the presence of left-sided obstructive lesions. 相似文献
45.
Miriam Stewart Linda Reutter Edward Makwarimba Irving Rootman Deanna Williamson Kim Raine Doug Wilson Janet Fast Rhonda Love Sharon McFall Deana Shorten Nicole Letourneau Karen Hayward Jeff Masuda William Rutakumwa 《Revue canadienne de recherche en sciences infirmières》2005,37(3):104-131
Poverty influences health status, life expectancy, health behaviours, and use of health services. This study examined factors influencing the use of health-related services by people living in poverty. In the first phase, 199 impoverished users of health-related services in 2 large Canadian cities were interviewed by their peers. In the second phase, group interviews with people living in poverty (n = 52) were conducted. Data were analyzed using thematic content analysis. Diverse health-related services were used to meet basic and health needs, to maintain human contact, and to cope with life's challenges. Use of services depended on proximity, affordability, convenience, information, and providers' attitudes and behaviours. Use was impeded by inequities based on income status. To promote the health of people living in poverty, nurses and other health professionals can enhance the accessibility and quality of services, improve their interactions with people living in poverty, provide information about available programs, offer coordinated community-based services, collaborate with other sectors, and advocate for more equitable services and policies. 相似文献
46.
Linda S Baas 《Dimensions of critical care nursing》2004,23(3):131-138
An ex post facto correlational study was conducted to examine predictors of quality of life in persons 3 to 6 months after a myocardial infarction. Self-care resources, self-care knowledge (needs), activity level, and selected demographic variables were examined as predictor variables. A convenience sample of 86 subjects with a mean age of 61 years, was recruited for participation in this study. The study that explained 35% of the variance in quality of life included self-care resources available, activity level, and self-care needs. Modeling and Role Modeling Paradigm provided a useful explanation of how self-care resources and self-care knowledge can be applied to persons recovering from myocardial infarction. 相似文献
47.
Objective. To determine the stability of an admixture combining ziconotide with bupivacaine hydrochloride during simulated intrathecal infusion under laboratory conditions at 37°. Materials and Methods. An admixture containing ziconotide (25 µg/mL) and bupivacaine hydrochloride (5 mg/mL) was stored in SynchroMed® II pumps at 37° and in control vials at either 37° or 5°. Using high‐performance liquid chromatography, drug concentrations were determined from samples obtained at varying intervals during the 30‐day study. Results. After 30 days, pump ziconotide and bupivacaine hydrochloride concentrations measured an average of 86.9% and 99.4% of their initial concentrations, respectively. Control vials displayed similar degradation rates for both drugs. Statistical evaluation of the ziconotide 95% confidence interval indicated that the ziconotide concentration would meet or exceed 90% and 80% of initial concentration for 22 days and 45 days, respectively. Conclusions. An admixture containing 25 µg/mL ziconotide and 5 mg/mL bupivacaine hydrochloride was 90% stable for 22 days and 80% stable for 45 days (extrapolated) in SynchroMed® II infusion pumps. 相似文献
48.
Perry D. Cohen Linda Herman Sheryl Jedlinski Peggy Willocks Paula Wittekind 《Neurotherapeutics》2007,4(3):537-544
A patient-centered paradigm for clinical research and medical care is presented as a solution to the problem of declining
innovation and increasing costs and development time in the pipeline for new therapies. Fundamental differences in values
and motivations among scientists, clinicians, industry sponsor, and patients in neurotherapeutics provide a framework for
analysis of ethical conflicts and the loss of public confidence in medical research. Parkinson advocates’ views on clinical
trial participation, perceived risks and benefits, placebo controls, and sham surgery are presented. These views reflect the
sense of urgency and the unique perspective that comes from living with this progressive, debilitating condition full time.
A patient-centered paradigm that includes authentic voices of patients as collaborators at every stage of development will
help to resolve conflicts, build trust, recruit trial participants, and accelerate new therapies. Key elements are adaptive
clinical trial methods and the development of information technology for the assessment of outcomes and surveillance of safety
over the life cycle of a medical product. Supported by the Parkinson’s Disease Foundation, the Parkinson Pipeline Project
is a grassroots group of Parkinson’s patients whose goal is to represent an authentic voice for patients in the treatment
development process. This group promotes education and communication between members of the Parkinson’s community and active
stakeholders in medical research, industry, and regulatory agencies. Its members are an example of a new breed of knowledgeable
consumers, armed with first-hand access to research findings and reinforced by on-line connections to like-minded peers throughout
the world. 相似文献
49.
Society is currently on the threshold of a new revolution in understanding the interaction of genes and the environment. This research has profound implications for understanding occupational disease and will present ethical challenges to occupational health practice. The public must be educated about the potential promise, as well as the threats, posed by emerging genetic technologies. 相似文献
50.