A high intake of dietary fiber influences C-reactive protein and fibrinogen,but not glucose and lipid metabolism,in mildly hypercholesterolemic subjects

Purpose

The aim of the study was to investigate how a diet high in dietary fiber, with several fiber sources included, modulates glucose and lipid metabolism and the inflammatory response in humans.

Methods

Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a BMI of 26.6 (0.5) kg/m² and a total cholesterol (TC) of 5.8 (0.1) mmol/L (mean and SEM) were given a high fiber (HF) and low fiber (LF) diet, in a randomized controlled 5-week crossover intervention, separated by a 3-week washout. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products; one bread roll, one ready meal, and two beverages consumed daily. Equivalent food products, without added fibers, were provided in the LF diet.

Results

Total dietary fiber intake was 48.0 g and 30.2 g per day for the HF and LF diet, respectively. Significant reduction in C-reactive protein (CRP) was observed between the diets (P = 0.017) and a significant reduction in fibrinogen within the HF diet (P = 0.044). There were no significant effects in other measured circulating cytokines or in glucose, insulin, and lipid levels.

Conclusions

Our study suggests that a 5-week high dietary fiber intake of oat bran, rye bran, and sugar beet fiber might reduce the low-grade inflammatory response measured as CRP which could, together with reduced fibrinogen, help to prevent the risk of cardiovascular disease.     

Influence of resistant starch alone or combined with wheat bran on gastric emptying and protein digestion in healthy volunteers

OBJECTIVE: Resistant starch (RS) is not absorbed in the small intestine, but is partly fermented in the colon and may positively influence putative risk factors for colon cancer. The purpose of the study was to investigate the influence of RS type 3 (retrograded amylose) alone or combined with wheat bran on gastric emptying (GE) and protein assimilation. MATERIAL AND METHODS: GE and protein assimilation were investigated by means of breath-test technology in 20 healthy volunteers who were randomly divided into two groups, each subject performing two tests. In each test, the volunteers received a labelled test meal either as such or in combination with, respectively, 15 g RS3 or 15 g RS3 combined with 6 g wheat bran (WB). Breath samples were collected during the 6 h after administration of a test meal containing egg proteins, intrinsically labelled with (13)C-leucine, to measure protein digestion and sodium-(14)C-octanoate for measurement of GE. RESULTS: Intake of RS3 +WB did not influence GE time compared to baseline values, whereas intake of RS3 seemed to hasten GE: from 93 +/- 32 min to 55 +/- 15 min (p = 0.012). The overall protein assimilation parameters at baseline were not significantly different from those obtained after simultaneous intake of RS3 +WB, whereas RS3 significantly shortened the time of maximum excretion compared to baseline, but the extent of protein digestion after RS3 intake was not affected (12.54 +/- 3.60% versus 13.43 +/- 3.40%). CONCLUSIONS: The presence of RS3 alone or in combination with wheat bran demonstrates that there are no adverse effects on protein digestion and no influence on the nitrogen supply to the colon.     

Beitrag zur Frage der Abwehrleistungen bei neugeborenen und jungen Kaninchen

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