Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder, occurring predominantly in women. We studied by flow cytofluorimetry the T cell subsets in men and women with ITP and compared them with healthy sex-matched volunteers. In healthy controls, women were found to have higher proportions of T helper/inducer (Th/i) and lower T suppressor/cytotoxic (Ts/c) lymphocytes and consequently higher Th/i:Ts/c ratios than men. Accordingly, in clinical surveys, patients and controls should be matched for sex for proper comparisons. In patients with ITP in its active phase, an imbalance in T cell subsets was found in both sexes. The perturbation was more severe in women who had a marked decrease in number and proportion of Th/i lymphocytes and an increase in the proportion of Ts/c lymphocytes, whereas in men only, the proportion of Th/i lymphocytes was decreased. When patients with active disease were compared to those with ITP in remission, the decrease in Th/i subsets still persisted in both sexes but the Ts/c subset in women had returned to normal proportions. Therefore, the immune imbalance in ITP is more marked in women than men; imbalances in both Th/i and Ts/c are present in women while Ts/c appears not to be involved in men.     

Calcified sphenoid mucocele

Sphenoid sinus mucoceles are uncommon lesions, and may rarely contain calcifications within their wall. We describe a new appearance of this lesion--sphenoid sinus mucocele with gross calcifications within its matrix.     

Eccentric cystic facial schwannoma: CT and MR features

Facial schwannomas are uncommon lesions with a fairly characteristic range of clinical and radiographic presentations. This report describes an unusual case of facial schwannoma that clinically and radiographically mimicked a cystic skull base lesion extrinsically compressing the facial nerve. The MR findings are presented.     

An immunohistochemical study of serotonin neuron development in the rat: Ascending pathways and terminal fields

The ontogeny of the serotonergic axonal projections may be divided into three periods: one of initial axon elongation (E12-E16), the development of selective pathways (E15-E19) and terminal field development (E19-E21). All serotonergic axons that enter the prosencephalon ascend in the medial forebrain bundle From this bundle fascicles of immunoreactive axons enter several well-defined fiber tracts: specifically, the fasciculus retroflexus, stria medullaris, external capsule, fornix, and supracallosal stria. Axons from these pathways form terminal arborizations in the thalamus, hypothalamus, basal and limbic forebrain, and cerebral cortex. Serotonergic axons appear to be guided by pre-existing non-serotonergic tracts in reaching targets in the forebrain. Innervation of the cerebral cortex is a prolonged process extending from E19 through PND21. Axons enter directly into the marginal and intermediate zones of the immature cortex, at the medial, frontal and lateral edges of the hemisphere, and subsequently spread tangentially to cover the hemispheres. Terminal ramifications then arise from the bilaminar axons and fill in the middle cortical layers. This growth pattern gives rise to tangential and radial gradients in innervation density. While the growth of serotonin axons across the forebrain appears to be a continuous, sequential process, the development of terminal innervation is highly heterogeneous, occurring at different times and at different rates from region to region. Serotonergic axons do not innervate immature, primarily proliferative neuronal populations. The delay in serotonin innervation of the suprachiasmatic nucleus, striatum, and middle cortical layers long after the axons have reached these structures suggests that the formation of serotonin axon terminals is dependent on maturation of other elements in local neuronal circuitry.