全文获取类型
收费全文 | 87篇 |
免费 | 13篇 |
专业分类
基础医学 | 9篇 |
口腔科学 | 3篇 |
临床医学 | 33篇 |
内科学 | 7篇 |
神经病学 | 2篇 |
特种医学 | 26篇 |
外科学 | 17篇 |
药学 | 2篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 10篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 6篇 |
2016年 | 5篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 5篇 |
2012年 | 4篇 |
2010年 | 2篇 |
2009年 | 1篇 |
2008年 | 2篇 |
2007年 | 10篇 |
2006年 | 6篇 |
2005年 | 7篇 |
2004年 | 7篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2000年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有100条查询结果,搜索用时 15 毫秒
41.
42.
Acute porcine renal metabolic effect of endogastric soft drink administration assessed with hyperpolarized [1‐13c]pyruvate 下载免费PDF全文
43.
Hyperpolarized 13C urea relaxation mechanism reveals renal changes in diabetic nephropathy 下载免费PDF全文
44.
Peter Agger Camilla Omann Christoffer Laustsen Robert S. Stephenson Robert H. Anderson 《NMR in biomedicine》2020,33(3)
Diffusion tensor imaging has been used for assessing the orientation of cardiac myocytes for decades. Striking methodological differences exist between studies when quantifying these orientations. This limits the comparability between studies, and impedes collaboration and the drawing of appropriate physiological conclusions. We have sought to elucidate these differences, permitting us to propose a standardised “tool set” that might better establish consensus in future studies. We fixed hearts from seven 25 kg pigs in formalin, and scanned them using diffusion tensor imaging. Using various angle definitions as found in literature, we assessed the orientations of cardiomyocytes, comparing them in terms of helical and intrusion angles, along with the orientation of their aggregations. The difference between assessment of the helical angle with and without relation to the epicardial curvature was 25.2° (SD: 7.9) at the base, 5.8° (1.9) at the equatorial level, and 28.0° (7.0) at the apex, ANOVA P = 0.001. In comparable fashion, the intrusion angle differed by 25.9° (12.9), 7.6° (0.98) and 17.5° (4.7), P = 0.01, and the angle of the aggregates (E3‐angle) differed by 25.0° (13.5) at the base, 9.4° (1.7) at the equator, and 23.1° (6.2) apically, P = 0.003. When assessing 14 definitions used in literature to calculate the orientation of aggregates, only 4 rendered identical results. The findings show that any attempt to use projection of eigenvectors introduces considerable bias. The epicardial curvature of the ventricular cone needs to be taken into account when seeking to provide accurate quantification of the orientation of the aggregated cardiomyocytes, especially in the apical and basal regions. This means that projection of eigenvectors should be avoided prior to quantifying myocyte orientation, especially when assessing radial orientation. Based on our results, we suggest appropriate methods for valid assessment of myocyte orientation using diffusion tensor imaging. 相似文献
45.
46.
Rasmus Stilling Tougaard Esben Svs Szocska Hansen Christoffer Laustsen Thomas Stokholm Nrlinger Emmeli Mikkelsen Jakob Lindhardt Per Mose Nielsen Lotte Bonde Bertelsen Marie Schroeder Hans Erik Btker Won Yong Kim Henrik Wiggers Hans Stdkilde‐Jrgensen 《Magnetic resonance in medicine》2019,81(4):2655-2665
47.
Haiyun Qi Christian
stergaard Mariager Per Mose Nielsen Marie Schroeder Jakob Lindhardt Rikke Nrregaard Janet D. Klein Jeff M. Sands Christoffer Laustsen 《NMR in biomedicine》2019,32(1)
Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handling; however, the exact mechanism has still to be fully understood. Here we investigate renal function and osmolite distribution using [13C,15N] urea dynamics and 23Na distribution before and 60 min after glucagon infusion in six female rats. Glucagon infusion increased the renal [13C,15N] urea mean transit time by 14%, while no change was seen in the sodium distribution, glomerular filtration rate or oxygen consumption. This change is related to the well‐known effect of increased urea excretion associated with glucagon infusion, independent of renal functional effects. This study demonstrates for the first time that hyperpolarized 13C‐urea enables monitoring of renal urinary excretion effects in vivo. 相似文献
48.
49.
Anne C. van Erp Haiyun Qi Nichlas R. Jespersen Marie V. Hjortbak Petra J. Ottens Janneke Wiersema‐Buist Rikke Nrregaard Michael Pedersen Christoffer Laustsen Henri G. D. Leuvenink Bente Jespersen 《American journal of transplantation》2020,20(9):2425-2436
We investigated metabolic changes during brain death (BD) using hyperpolarized magnetic resonance (MR) spectroscopy and ex vivo graft glucose metabolism during normothermic isolated perfused kidney (IPK) machine perfusion. BD was induced in mechanically ventilated rats by inflation of an epidurally placed catheter; sham‐operated rats served as controls. Hyperpolarized [1‐13C]pyruvate MR spectroscopy was performed to quantify pyruvate metabolism in the liver and kidneys at 3 time points during BD, preceded by injecting hyperpolarized[1‐13C]pyruvate. Following BD, glucose oxidation was measured using tritium‐labeled glucose (d ‐6‐3H‐glucose) during IPK reperfusion. Quantitative polymerase chain reaction and biochemistry were performed on tissue/plasma. Immediately following BD induction, lactate increased in both organs (liver: eµd0.21, 95% confidence interval [CI] [?0.27, ?0.15]; kidney: eµd0.26, 95% CI [?0.40, ?0.12]. After 4 hours of BD, alanine production decreased in the kidney (eµd0.14, 95% CI [0.03, 0.25], P < .05). Hepatic lactate and alanine profiles were significantly different throughout the experiment between groups (P < .01). During IPK perfusion, renal glucose oxidation was reduced following BD vs sham animals (eµd0.012, 95% CI [0.004, 0.03], P < .001). No differences in enzyme activities were found. Renal gene expression of lactate‐transporter MCT4 increased following BD (P < .01). In conclusion, metabolic processes during BD can be visualized in vivo using hyperpolarized magnetic resonance imaging and with glucose oxidation during ex vivo renal machine perfusion. These techniques can detect differences in the metabolic profiles of the liver and kidney following BD. 相似文献
50.