Differential effects of right hemisphere injection during the wada procedure on the primary and secondary languages in a bilingual speaker

Abstract

A Wada procedure was performed on a bilingual seizure surgery candidate. Immediately after the injection of barbiturate into the right internal carotid artery the patient spontaneously switched from counting in English (the language he indicated that he used most often) to Spanish (the language he learned first). He named in Spanish spontaneously as well. After injection of the left ICA the patient exhibited a global aphasia, with no evidence for differential recovery of language as the aphasia cleared. These observations are discussed in relation to the hypothesis that a language learned later in life may be more likely to be bilaterally represented than the first language learned.     

Tissue-resident T cells lose their SIP_1 exit visas

CD8 T cells play critical roles in controlling intracellular pathogensand tumors. To accomplish this the small number of antigen-inexperienced naive CD8 T cells that are capable of recognizing the antigen of interest must first become primed. These initial activaion events occur while the responding T cells are sequestered within lymph nodes, but many of the cells subsequently egress into the periphery and migrate into other organs where they can fulfill their principle mission of identifying and eliminating infected or malignant target cells.     

Inclinometric measurement of kyphotic curvature: Description and clinimetric properties

Background: Hyperkyphosis is associated with physical impairments, activity limitations, and reduced quality of life. Therefore, a simple, reliable, responsive, and valid clinical measure of dorsal kyphosis would be valuable to clinicians. Objective: To describe a novel procedure for measuring kyphotic curvature—the inclinometric kyphosis measure (IKM)—and provide an estimation of reliability, responsiveness, and validity. Methods: During 2 sessions spaced days apart, we used a bubble inclinometer to measure dorsal kyphosis in 68 patients receiving outpatient physical therapy. We also documented occiput-to-wall status and tragus-to-wall distance. Results: Intra-rater reliability of the IKM was supported by intra-class correlation coefficients (ICC_3,1) of 0.94 and 0.91 for relaxed and cued conditions, respectively. Responsiveness, as indicated by minimal detectable change, was 8.0 and 10.0 degrees under relaxed and cued conditions, respectively. Validity was supported by significant correlations between the IKM and tragus-to-wall and by differences in the IKM between: 1) relaxed and cued conditions; 2) patients who could and could not touch occiput to the wall; and 3) patients who were older versus younger than 50 years of age. Conclusions: The IKM is a simple, reliable, responsive, and valid method for assessing posture in patients with musculoskeletal conditions.