全文获取类型
收费全文 | 11427篇 |
免费 | 595篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 217篇 |
儿科学 | 374篇 |
妇产科学 | 206篇 |
基础医学 | 1333篇 |
口腔科学 | 316篇 |
临床医学 | 734篇 |
内科学 | 2945篇 |
皮肤病学 | 362篇 |
神经病学 | 743篇 |
特种医学 | 237篇 |
外国民族医学 | 1篇 |
外科学 | 1790篇 |
综合类 | 121篇 |
一般理论 | 4篇 |
预防医学 | 827篇 |
眼科学 | 299篇 |
药学 | 835篇 |
中国医学 | 50篇 |
肿瘤学 | 668篇 |
出版年
2023年 | 62篇 |
2022年 | 106篇 |
2021年 | 320篇 |
2020年 | 167篇 |
2019年 | 315篇 |
2018年 | 471篇 |
2017年 | 264篇 |
2016年 | 263篇 |
2015年 | 272篇 |
2014年 | 363篇 |
2013年 | 500篇 |
2012年 | 832篇 |
2011年 | 915篇 |
2010年 | 433篇 |
2009年 | 365篇 |
2008年 | 749篇 |
2007年 | 755篇 |
2006年 | 762篇 |
2005年 | 695篇 |
2004年 | 635篇 |
2003年 | 570篇 |
2002年 | 531篇 |
2001年 | 184篇 |
2000年 | 200篇 |
1999年 | 188篇 |
1998年 | 60篇 |
1997年 | 46篇 |
1996年 | 54篇 |
1995年 | 48篇 |
1994年 | 38篇 |
1993年 | 22篇 |
1992年 | 66篇 |
1991年 | 58篇 |
1990年 | 55篇 |
1989年 | 52篇 |
1988年 | 46篇 |
1987年 | 59篇 |
1986年 | 52篇 |
1985年 | 45篇 |
1984年 | 38篇 |
1983年 | 43篇 |
1982年 | 31篇 |
1981年 | 27篇 |
1980年 | 20篇 |
1979年 | 32篇 |
1978年 | 22篇 |
1977年 | 19篇 |
1975年 | 17篇 |
1974年 | 33篇 |
1973年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
93.
Ramón Mauricio Coral-Vázquez Juan Fernando Romero Arauz Samuel Canizales-Quinteros Agustín Coronel Elith Yazmin Valencia Villalvazo Jaime Hernández Rivera Belem Ramírez Regalado David Rojano Mejía Patricia Canto 《Clinical biochemistry》2013,46(7-8):627-632
ObjectiveSeveral studies have reported the association of genes related to vascular tone, hypertension, oxidative stress and preeclampsia. We investigated the possible association among three polymorphisms in eNOS (as well their haplotypes): one of MTHFR, one of GSTP1 and one of AGT, with severe preeclampsia in Mexican-Mestizo women.MethodsTwo hundred thirty women with severe preeclampsia and 350 control subjects were genotyped; for rs2070744 and rs1799983 of eNOS, rs1801133 of MTHFR, rs1695 of GSTP1 and rs699 of AGT we used real-time PCR allelic discrimination and for VNTR of eNOS, PCR. Allele frequency differences were assessed by χ2. Logistic regression was used to test for associations and for haplotype frequencies using Haploview 4.2.ResultsGenotypic and allelic distribution of the polymorphisms was similar between cases and controls; likewise, haplotype frequencies of the three polymorphisms of eNOS did not differ significantly.ConclusionsTo our knowledge, this is the first time that these polymorphisms have been analyzed together and exclusively in women with severe preeclampsia. However, we did not find an association between polymorphisms of eNOS, MTHFR, GSTP1 and AGT with severe preeclampsia in our population. Additionally, we observed differences in the distribution of the alleles and genotypes of these polymorphisms in our population in comparison to those described in other ethnic groups. 相似文献
94.
95.
Cannabinoid agonists such as Δ9-tetrahydrocannabinol (THC) are more potent and/or efficacious antinociceptive agents in female than male rats using acute pain models. We tested the hypothesis that THC is more effective in females than males using a model of longer-lasting, inflammatory pain. THC’s anti-allodynic, anti-hyperalgesic, and anti-edema effects were examined 1, 3, and 7 days after injection of complete Freund’s adjuvant (CFA) into the hind paw. Systemically administered THC (0.32–3.2 mg/kg, intraperitoneally [i.p.], same dose each day) was significantly more effective in females than males in attenuating CFA-induced thermal hyperalgesia, but was also more sedative in females. When administered locally into the inflamed hind paw, THC (250–500 μg intraplantar, i.pl.) did not affect locomotor activity in either sex, yet produced greater anti-allodynic and anti-hyperalgesic effects in females than males. Despite THC’s greater anti-allodynic and anti-hyperalgesic effects in females, both i.p. and i.pl. THC reduced hind paw thickness (edema) more in males. The anti-hyperalgesic effect of i.p. THC was blocked by the CB1 receptor-selective antagonist rimonabant in both sexes. Similarly, i.pl. rimonabant antagonized i.pl. THC’s effects in both sexes; in contrast, the CB2 antagonist SR144528 significantly attenuated i.pl. THC’s anti-allodynic effect only in females. Intraplantar SR144528 also antagonized i.pl. THC’s anti-edema effect in males. This study suggests that cannabinoids may be better at reducing edema in males while being more effective against inflammatory pain in females. Furthermore, sex differences in THC’s peripheral effects against inflammatory pain may be a result of activation of both types of cannabinoid receptors in females, in contrast to predominantly CB1 receptors in males. 相似文献
96.
B. S. Anuradha P. Pallavi V. Praveen Kumar S. Ram Reddy 《Proceedings of the National Academy of Sciences, India. Section B.》2013,83(1):105-108
Seventeen strains of alcoholic yeasts were screened for petite mutation frequency and killer phenotypes with an objective to develop them as industrial strains. The frequency of petite mutations varied with the strain. Though some strains have shown high frequency mutations, a few strains were found to be genetically stable. The killer property was found to vary with the strains. Interestingly, though some strains proved to be sensitive, some strains were found to be killer strains for marker killer strain also. Thus, the study provides the evidence that the killer principle varies with the strain. 相似文献
97.
98.
99.
Andrew Holden Andrew A. Hill Brendan Buckley Brigid Connor David Semple Stephen Merrilees Emma Marsh Aws Alfahad Ram Iyer 《Journal of vascular and interventional radiology : JVIR》2019,30(1):61-68
Purpose
A prospective, single-center, single-arm feasibility study evaluated procedural and short-term performance of the Advance Enforcer 35 focal-force percutaneous transluminal angioplasty (PTA) balloon catheter in treating stenoses of mature native arteriovenous (AV) hemodialysis access circuits.Materials and Methods
Twenty-eight patients undergoing treatment for stenosis of a mature native AV hemodialysis access circuit were enrolled at a single institution. Angiographic assessments of the study lesion were required at baseline and after the procedure. Adjunctive procedures for significant residual stenosis were permitted, and patients had clinical and imaging follow-up for as long as 6 months.Results
Treatment with the study balloon was effective in reducing the average percent diameter stenosis of the treated lesion from 66.3% (range, 43.8%–93.3%) before the procedure to 23.7% (range, ?6.7% to 51.4%) after the procedure. The average inflation pressure required was 12.3 atm. Only 1 patient required an adjunctive procedure, and all patients could resume normal dialysis following the study procedure. At 3 months, 62.0% of study lesions remained patent, and the 6-month patency rate was 25.1%. Two adverse events associated with the study procedure were reported: access-site hematoma and forearm pain (3.6% each).Conclusions
The results demonstrate safety of the study balloon in treating AV access stenosis. Nominal-diameter angioplasty was achieved at relatively low pressure in most study patients without the use of adjunctive procedures, and resumption of normal dialysis was achieved for all patients. 相似文献100.
A. Ríos S. López-Gómez J. Belmonte A. López-Navas A. Sánchez J. Carrillo J.J.A. Ruiz-Manzanera A.M. Hernández P. Ramírez P. Parrilla 《Transplantation proceedings》2019,51(2):293-295