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Mild heart failure is characterized by increases in atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in the absence of activation of the renin-angiotensin-aldosterone system (RAAS). Vasopeptidase (VP) inhibitors are novel molecules that coinhibit neutral endopeptidase 24.11, which degrades the natriuretic peptides (NPs) and ACE. In a well-characterized canine model of mild heart failure produced by ventricular pacing at 180 bpm for 10 days, we defined the renal and humoral actions of acute VP inhibition with omapatrilat (OMA, n=6) and acute ACE inhibition (n=5) alone with fosinoprilat. We also sought to determine whether the NPs participate in the renal actions of acute VP inhibition by the administration of OMA together with an intrarenal administration of the NP receptor antagonist HS-142-1 (n=5). OMA resulted in a greater natriuretic response than did ACE inhibition in association with increases in plasma cGMP, ANP, BNP, urinary cGMP, urinary ANP excretion, and glomerular filtration rate (P<0.05 for OMA versus ACE inhibition). Plasma renin activity was increased only in the group subjected to ACE inhibition. Administration of intrarenal HS-142-1 attenuated the renal properties of OMA in association with a decrease in urinary cGMP excretion despite similar increases in plasma ANP and BNP. This study provides new insight into a unique new pharmacological agent that has beneficial renal actions in experimental mild heart failure beyond the actions that are observed with ACE inhibition alone and that are linked to the NP system. 相似文献
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KH Nyqvist GC Anderson N Bergman A Cattaneo N Charpak R Davanzo U Ewald S Ludington‐Hoe S Mendoza C Pallás‐Allonso JG Peláez J Sizun A‐M Widström 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(6):812-819
Since Kangaroo Mother Care (KMC) was developed in Colombia in the 1970s, two trends in clinical application emerged. In low income settings, the original KMC model is implemented. This consists of continuous (24 h/day, 7 days/week) and prolonged mother/parent–infant skin‐to‐skin contact; early discharge with the infant in the kangaroo position; (ideally) exclusive breastfeeding; and, adequate follow‐up. In affluent settings, intermittent KMC with sessions of one or a few hours skin‐to‐skin contact for a limited period is common. As a result of the increasing evidence of the benefits of KMC for both infants and families in all intensive care settings, KMC in a high‐tech environment was chosen as the topic for the first European Conference on KMC, and the clinical implementation of the KMC model in all types of settings was discussed at the 7th International Workshop on KMC. Kangaroo Mother Care protocols in high‐tech Neonatal Intensive Care Units (NICU) should specify criteria for initiation, kangaroo position, transfer to/from KMC, transport in kangaroo position, kangaroo nutrition, parents’ role, modification of the NICU environment, performance of care in KMC, and KMC in case of infant instability. Conclusion: Implementation of the original KMC method, with continuous skin‐to‐skin contact whenever possible, is recommended for application in high‐tech environments, although scientific evaluation should continue. 相似文献
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Little DM; Farrell JG; Cunningham PM; Hickey DP 《QJM : monthly journal of the Association of Physicians》1997,90(10):641-642
Systemic donor infection is regarded as being an absolute contraindication
to cadaveric organ donation for transplantation. This is largely due to
fear of transmitting pathogenic organisms to the immunosuppressed
recipient. However, due to the current shortage of organs available for
transplantation, clinicians are faced with the option of using organs from
'non-ideal' donors, such as those patients with documented evidence of
infection. We report the successful outcome of six orthotopic liver
transplants, 11 renal transplants, one combined heart lung transplant and
one simultaneous kidney and pancreas transplant with organs from eight
donors in whom bacterial meningitis (n = 7) and acute bacterial
epiglottitis (n = 1) were the antecedent causes of death.
相似文献
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Internal mammary compartment: window to the mediastinum 总被引:1,自引:0,他引:1
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钙拮抗剂TMB-8抑制BHQ,NE和KCl引起的培养乳牛基底动脉单个平滑肌细胞内游离钙的升高 总被引:1,自引:0,他引:1
用ARCMMIC阳离子测定系统,测量单个细胞内游离钙浓度([Ca2+]i),研究8(N,N二乙胺)n辛基3,4,5三甲氧基苯甲酸酯(TMB8)对培养乳牛基底动脉平滑肌[Ca2+]i的作用。在细胞外钙浓度为13mmol·L-1时,TMB8(30μmol·L-1)可明显抑制BHQ,NE及KCl引起[Ca2+]i的升高。在细胞外钙为零+EGTA01mmol·L-1时,TMB8(10,30及100μmol·L-1)可浓度依赖性地降低静息[Ca2+]i,TMB8(30μmol·L-1)可几乎完全阻断BHQ及NE引起[Ca2+]i的增加。研究表明TMB8降低培养乳牛基底动脉平滑肌[Ca2+]i的机制,主要是抑制肌浆网Ca2+的释放,或增加肌浆网对Ca2+的摄入,并由此间接地抑制细胞外钙的内流。 相似文献