NONSEGMENTAL VITILIGO: DECREASE OF THE CD45RA+ T-CELL SUBSET AND EVIDENCE EOR PERIPHERAL T-CELL ACTIVATION

Peripheral T-lymphocytes from 16 randomly selected patients with nonsegmental vitiligo were labeled with monoclonal antibodies recognizing T-cell receptor (TCR) alpha/beta, TCR gamma/delta, CD3, CD4, CD8, CD45RA, CD45RO, CD11b, CD11c, CD16, CD56, CD25, CD54, and HLA-DR antigens. In comparison with matched controls, a significant decrease of the CD45RA+ subset (P less than 0.03) together with significant increase of the circulating HLA-DR+ cells (P less than 0.02) was found. No other alterations were detected. These findings may point to some autoimmune phenomena involved in the pathogenesis of the disease. The increased HLA-DR expression indicates the presence of activated peripheral T-cells. Thus, our data provide new and further evidence for T-cell dysregulation in nonsegmental vitiligo.     

心脏起搏离子通道的分子结构和功能特性(英文)

心脏的起搏受控于一类存在于心脏窦房结被称作If 的离子通道 ,该通道是被细胞膜的超极化所激活 .新近 ,一类被命名为超极化激活及环化核苷酸调控的阳离子 (HCN)通道被克隆 .该家族至少有4个成员 ,即HCN1～HCN4 .其中 2个HCN2和HCN4在心脏有丰富表达 .用异体表达系统表达克隆的HCN2和HCN4通道蛋白 ,其通道特性类似心脏的天然If 通道 .本综述讨论了HCN通道之间的分子结构差异 ,功能性表达特点以及与它们功能特性有关的分子结构     

Automatic Adjustment of Pacemaker Stimulation Output Correlated with Continuously Monitored Capture Thresholds: A Multicenter Study

Pacing threshold is affected by many factors. A pacing system able to confirm capture at each beat and automatically adjust its output close to the actual pacing threshold is highly desirable. This study evaluates the safety and efficacy of the Autocapture function of the Pacesetter Microny SR+. One hundred thirteen patients were recruited from 16 centers in 7 European countries and followed up for 1 year. All pacemakers were implanted with Pacesetter's low polarization, bipolar leads. The key feature of Autocapture is the immediate delivery of a 4.5 V safety backup pulse 62.5 ms after any ineffective ongoing low output pulse. Holter recordings confirmed total reliability of this feature without any exit block. The measured evoked response (ER) signal was stable over time. Acute and chronic pacing thresholds measured by VARIO and Autocapture tests correlated (r > 0.79) over the period of the study. The incidence of backup pulses was 1.1% during pacing. With Autocapture programmed ON, the overall total current consumption was 4.1 μA for VVI and 5.0 μA for VVIR pacing. Tbis study proved that the Autocapture safely and reliably regulates the pacemaker's output according to the prevailing threshold thus providing maximum patient safety and prolonging service life.