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91.
92.
Min-Ho Shin Jin-Su Choi Jung-Ae Rhee Young-Hoon Lee Hae-Sung Nam Seul-Ki Jeong Kyeong-Soo Park Hye-Yeon Kim So-Yeon Ryu Seong-Woo Choi Hee Nam Kim Hye-Rim Song Jane A. Cauley Sun-Seog Kweon 《Atherosclerosis》2014
Objective
We evaluated the association between APOE polymorphism and carotid atherosclerosis in two large independent cohorts from South Korea.Methods
The datasets were from the Dong-gu Study (N = 9056) and the Namwon Study (N = 10,158). Carotid ultrasonography was performed to measure carotid intima-media thickness (IMT) and the presence of carotid plaques. The APOE polymorphism was determined by PCR-RFLP. We performed combined and separate analyses for the two datasets.Results
In the combined analysis, individuals with E2E2 or E2E3 genotype had a lower common carotid IMT compared with individuals with E3E3 genotype (0.684 mm vs. 0.736 mm, p = 0.007; 0.718 mm vs. 0.736 mm, p < 0.001, respectively). This association was very slightly attenuated but remained statistically significant after adjustment for blood lipids (0.690 mm vs. 0.736 mm, p = 0.033; 0.725 mm vs. 0.736 mm, p = 0.005, respectively). Compared with individuals with E3E3 genotype, individuals with E2E3 genotype had lower risk for carotid plaque (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.75–0.93), while individuals with E3E4 genotype had a higher risk for carotid plaque (OR = 1.09, 95% CI = 1.00–1.20). After adjustment for blood lipids, ORs of E2E3 genotype for carotid plaque was slightly attenuated but remained significant (OR = 0.87 95% CI = 0.78–0.97), while OR of E3E4 genotype were slightly attenuated and not significant (OR = 1.08, 95% CI, 0.99–1.18).Conclusions
We found that APOE polymorphism is associated with carotid atherosclerosis and this association was partly mediated through blood lipid. Our results suggest that APOE polymorphism may influence atherosclerosis through non-lipid pathways. 相似文献93.
E. Rosser RN DPhil MN RM Dip N Ed Dip RM PFHEA E. Buckner RN PhD CNE AE-C FNAP T. Avedissian RN MSN D.S.K. Cheung BN MSc PhD K. Eviza RN MSN T. B. Hafsteinsdóttir RN PhD M.Y. Hsu RN PhD MSc M. N. Kirshbaum RN BSc MSc PhD GDip Health Ed Dip Onc Dip Counselling Dip CBT FHEA C. Lai RN PhD Y.C. Ng PhD J. Ramsbotham RN PhD MN S. Waweru RN MSN FNP-BC 《International nursing review》2020,67(4):484-494
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97.
Kohtaro Fujihashi Mi-Na Kweon Hiroshi Kiyono John L. VanCott Frederick W. van Ginkel Masafumi Yamamoto Jerry R. McGhee 《Springer Seminars in Immunopathology》1997,18(4):477-494
Conclusions Mucosal immune responses are strongly regulated by CD4+ T cells and their derived cytokines. In this regard, IFN-–/– mice (i.e., which lack Th1 and have elevated Th2 cells) showed strong mucosal Th2-type responses together with S-IgA production, while IL-4–/– (e.g., dominant Th1 and lack of Th2 cells) mice had impaired mucosal Th2 and IgA responses following oral delivery of TT and CT. However, when rSalmonella or radenovirus were used for antigen delivery, significant levels of mucosal IgA responses were induced in both IFN-–/– and IL-4–/– mice. The choice of the antigen delivery system which leads to optimal Th and B cell interactions are important for the induction of effective IgA responses, even in situations where the immune system is compromised. It is clear that Th2-type cytokines are important in mucosal IgA responses; however, other cytokine combinations can compensate for mucosal immunity in situations in which Th2 cell responses are absent. Mucosally induced tolerance may be one approach to prevent several systemic immune disorders; however, the mechanism of this phenomenon still needs to be elucidated. Our recent findings have suggested that IFN- may play an important role in induction of systemic unresponsiveness since oral tolerance was not induced in IFN-–/– mice.Our studies as well as those of others indicated that at least two phases of a triad of cell interactions are important for the mucosal immune system. First, it has been shown that epithelial cell-produced IL-7 and SCF and T cell-derived IL-2 are essential activation and growth signals for intestinal T cells. Second, our studies with TCR knockout mice have suggested that mucosal T cells also play a critical role in the regulation of mucosal IgA responses. Thus, a mucosal internet among T cells, T cells, and IgA B cells appear critical for mucosal homeostasis and for regulation of specific mucosal immune responses. 相似文献
98.
Summary. The deletion of the thymidine kinase (TK) gene of herpesviruses causes a reduction in their virulence. However, the effects
of the TK gene in infectious laryngotracheitis virus (ILTV) have not been clearly elucidated. In the present study, we constructed
a TK gene-deleted recombinant ILTV expressing the green fluorescent protein (GFP) gene as a marker. The GFP gene was inserted
in place of the TK gene in both virulent and low virulence strains of ILTV. The GFP gene in the recombinants was expressed
in chicken kidney cells, LMH cells and in the chorioallantoic membrane of embryonated chicken eggs. The recombinants produced
cytopathic effects in chicken kidney cells and LMH cells and formed pocks in the chorioallantoic membrane of embryonated chicken
eggs. The growth rate of the recombinant in chicken kidney cells was similar to that of wild type viruses. The recombinants
showed a reduction of virulence compared to that of parental viruses and induced protection against virulent ILTV in specific
pathogen free chickens. The recombinant expressing GFP gene may be a candidate for a genetically engineered vaccine and provide
a means to study growth kinetics and mechanism of latent infection and reactivation of ILTV. In this study, we confirmed that
the TK gene is directly related to virulence of ILTV. This is the first report to show the evidence that the TK gene is a
major gene related to virulence of ILTV.
Received May 1, 2001; accepted November 14, 2001 相似文献
99.
Eriko Anzai RN MN Clint Douglas RN PhD Ann Bonner RN PhD 《Nursing & health sciences》2014,16(2):171-178
The purpose of this study was to describe Japanese hospital nurses' perceptions of the nursing practice environment and examine its association with nurse‐reported ability to provide quality nursing care, quality of patient care, and ward morale. A cross‐sectional survey design was used including 223 nurses working in 12 acute inpatient wards in a large Japanese teaching hospital. Nurses rated their work environment favorably overall using the Japanese version of the Practice Environment Scale of the Nursing Work Index. Subscale scores indicated high perceptions of physician relations and quality of nursing management, but lower scores for staffing and resources. Ward nurse managers generally rated the practice environment more positively than staff nurses except for staffing and resources. Regression analyses found the practice environment was a significant predictor of quality of patient care and ward morale, whereas perceived ability to provide quality nursing care was most strongly associated with years of clinical experience. These findings support interventions to improve the nursing practice environment, particularly staffing and resource adequacy, to enhance quality of care and ward morale in Japan. 相似文献
100.