全文获取类型
收费全文 | 1136篇 |
免费 | 110篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 101篇 |
儿科学 | 20篇 |
妇产科学 | 36篇 |
基础医学 | 202篇 |
口腔科学 | 21篇 |
临床医学 | 98篇 |
内科学 | 321篇 |
皮肤病学 | 5篇 |
神经病学 | 57篇 |
特种医学 | 29篇 |
外科学 | 139篇 |
综合类 | 5篇 |
预防医学 | 50篇 |
眼科学 | 36篇 |
药学 | 46篇 |
肿瘤学 | 89篇 |
出版年
2022年 | 12篇 |
2021年 | 14篇 |
2020年 | 11篇 |
2019年 | 17篇 |
2018年 | 21篇 |
2016年 | 19篇 |
2015年 | 19篇 |
2014年 | 26篇 |
2013年 | 25篇 |
2012年 | 36篇 |
2011年 | 51篇 |
2010年 | 20篇 |
2009年 | 22篇 |
2008年 | 37篇 |
2007年 | 42篇 |
2006年 | 49篇 |
2005年 | 47篇 |
2004年 | 53篇 |
2003年 | 49篇 |
2002年 | 50篇 |
2001年 | 60篇 |
2000年 | 51篇 |
1999年 | 54篇 |
1998年 | 17篇 |
1997年 | 14篇 |
1996年 | 17篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1992年 | 22篇 |
1991年 | 21篇 |
1990年 | 26篇 |
1989年 | 36篇 |
1988年 | 29篇 |
1987年 | 34篇 |
1986年 | 18篇 |
1985年 | 17篇 |
1984年 | 12篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1979年 | 11篇 |
1977年 | 16篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1974年 | 17篇 |
1973年 | 13篇 |
1972年 | 14篇 |
1971年 | 8篇 |
1968年 | 8篇 |
1967年 | 8篇 |
1966年 | 12篇 |
排序方式: 共有1255条查询结果,搜索用时 31 毫秒
41.
42.
S. Onoyama T. Hoshina S. Honjo K. Ihara T. Hara 《European journal of clinical microbiology & infectious diseases》2013,32(10):1353-1357
Children with severe motor intellectual disabilities (SMID) are at high risk of death from acute viral lower respiratory tract infections (LRTI). Although respiratory syncytial virus (RSV) is the most common cause of viral LRTI in children, there have been a few reports on the relationship between SMID and the severity of RSV-LRTI. The aim of the present study is to assess the influence of RSV-LRTI in children with SMID. A case–control study composed of children with SMID (n?=?18) and previously healthy children (n?=?43) less than 16 years old hospitalized for RSV-LRTI was performed during five consecutive RSV seasons. The clinical presentation and the laboratory data in the SMID group were compared with those in the non-SMID group. In the bivariate analysis, the median age of the SMID group was higher than that of the non-SMID group (p?=?0.002). Children with SMID had an increased risk for ventilation support (p?=?0.057). The count of neutrophils in the SMID group was significantly increased (p?=?0.012), whereas the proportion of bacterial co-infection was lower than that in the non-SMID group (p?=?0.005). Multivariate logistic analysis showed that SMID was associated with longer oxygen usage [>7 days: odds ratio (OR) 5.309, p?=?0.033]. The present study revealed that children with SMID were prone to developing hypoxia by RSV-LRTI. The strategies for the treatment and prevention of RSV infection need to be improved in SMID children. 相似文献
43.
Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension 总被引:7,自引:0,他引:7
Uzzaman M Honjo H Takagishi Y Emdad L Magee AI Severs NJ Kodama I 《Circulation research》2000,86(8):871-878
The present study investigates the remodeling of gap junctional organization in relation to changes in anisotropic conduction properties in hypertrophied right ventricles (RVs) of rats with monocrotaline (MCT)-induced pulmonary hypertension. In contrast to controls that showed immunolocalization of connexin43 (Cx43) labeling largely confined to the intercalated disks, RV myocytes from MCT-treated rats showed dispersion of Cx43 labeling over the entire cell surface. The disorganization of Cx43 labeling became more pronounced with the progression of hypertrophy. Desmoplakin remained localized to the intercalated disks, as in controls. In RV tissues, the proportion of Cx43 label at the intercalated disk progressively decreased. Quantitative analysis of en face views of intercalated disks revealed a significant decrease in the disk gap junctional density in RV tissues of MCT-treated rats (control, 0.18 versus MCT-treated, 0.14 at 2 weeks; control, 0.16 versus MCT-treated, 0.11 at 4 weeks). Conduction velocity in RVs parallel to the fiber orientation was significantly lower (30.2% [n=9]) in MCT-treated rats at 4 weeks than in control rats, whereas there was no significant difference observed in the conduction velocity across the fiber orientation between control and MCT-treated rats. The anisotropic ratio of MCT-treated rats (1.38+/-0.10) was significantly lower than that of control rats (1.98+/-0.12). These results suggest that RV hypertrophy induced by pressure overload is associated with both disorganization of gap junction distribution and alteration of anisotropic conduction properties. 相似文献
44.
Satoshi Honjo Yoko Murakami Hiroshi Odajima Yuichi Adachi Koichi Yoshida Yukihiro Ohya Akira Akasawa 《Allergology international》2019,68(1):26-32
Background
Atopic dermatitis (AD) and exercise-induced asthma (EIA) are common in asthmatic children, and exercise is the most common trigger other than infection for acute onset asthma attack in children. We examined whether AD is related to exercise-induced wheezing (EIW), some proxy for EIA.Methods
Japanese version of the International Study of Asthma and Allergies in Childhood questionnaires were used. For 12,405 asthmatic school children, AD was defined as itchy rash coming and going for at least 6 months at any time in the last 12 months with affecting places of flexural parts of body, and severity of AD was rated according to frequency of being kept awake at night with the itch as follows: never in the past 12 months, less than one night per week and one or more nights per week.Results
Adjusted for frequency of asthma attack, odds ratios (OR) of children with current AD as compared to those without AD for having EIW were 1.32 (95% confidence interval = 1.15–1.52), 1.35 (1.14–1.68) and 1.10 (0.92–1.31) for primary school, junior high school and high school children, respectively. EIW was more likely observed in accordance with increasing severity of AD in the primary school children with ORs of 1.12, 1.59 and 1.54 (p for trend < 0.01), and in the junior high school ones with ORs of 1.18, 1.31, 2.03 (<0.01), respectively.Conclusions
AD may be possibly related to EIW. Further studies investigating effect of AD treatment on EIW may be required. 相似文献45.
46.
Estrogen and non-feminizing estrogen for Alzheimer's disease 总被引:3,自引:0,他引:3
Honjo H Iwasa K Fushiki S Hosoda T Tatsumi H Mihara M Hirasugi Y Oida M Kariya K Kikuchi N Kawata M 《Endocrine journal》2003,50(4):361-367
The preventive effect of estrogen on Alzheimer's disease (AD) has become clearer with many epidemiological reports. However, the therapeutic effects of estrogen have been controversial until now. In our trials, estrogen treatment showed a beneficial therapeutic effect for women with mild to moderate AD. Improvement of cognitive function was recognized during the third week from the beginning of administration and maintained as long as estrogen treatment continued. The longer the duration of HRT, the more HRT is useful for the prevention and therapy of AD. However, in most cases, administration of estrogen is discontinued because of the adverse effects on the uterus and breast. J 861 is a derivative of estradiol-17alpha, which has little effect on the sexual organs. The effects of estradiol-17beta (E2) and J 861 on neuronal function and vascular factors were investigated. J 861 was suggested to prevent both the intracellular calcium increase and peroxidation induced by amyloid beta (Abeta), more effectively than E2. The effect of J 861 may be related with both the direct non-genomic and the ER-mediated systems. J 861 showed neurotrophic effects like E2. J 861 inhibited the adhesion of monocytes to vascular endothelium, more effectively than E2. Also, J 861 suppressed the expression of adhesive factors, such as E-selectin and intercellular cell adhesion molecule-1 (ICAM-1), more effectively than E2. 相似文献
47.
Schinzel–Giedion syndrome in two Brazilian patients: Report of a novel mutation in SETBP1 and literature review of the clinical features
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
48.
49.
50.