Versagung einer Apothekenbetriebserlaubnis wegen Vereinbarung einer Umsatzmiete für ein Medizinisches Versorgungszentrum

Abstrakt 1. Die Vereinbarung einer am Umsatz oder Gewinn einer Apotheke ausgerichteten Miete ist nach § 8 S. 2 ApoG unzul?ssig. Das Verbot der Umsatzmiete gilt insbesondere für die Anmietung von Apothekenbetriebsr?umen. 2. Aus dem Gesamtgefüge der Vereinbarungen kann sich ergeben, dass die Vertragsparteien die Miete am Umsatz oder Gewinn ausgerichtet haben und der Vermieter dadurch an den Ertr?gnissen der Apotheke teilhat. 3. Ein immens hoher Mietzins engt die wirtschaftliche Bewegungsfreiheit des Apothekers erheblich ein und macht ihn zumindest indirekt vom Vermieter abh?ngig. 4. Der Umstand, dass die Apothekenansiedlung im Kontext eines Medizinischen Versorgungszentrums geplant ist, ?ndert nichts an der uneingeschr?nkten Geltung des § 8 S. 2 ApoG. (Leits?tze des Bearbeiters)     

Features of myocardial metabolism of adenylic nucleotides in patients with paroxysmal tachycardias

The authors revealed that concentrations of inosin, hypoxanthine and their total levels in the arterial blood and the blood of the coronary sinus in patients with paroxysmal tachycardias are higher than the corresponding levels in patients with chronic forms of coronary heart disease and neurocirculatory dystonia. In the absence of tachycardia, there was an accelerated metabolism of adenyl nucleotides of the myocardium: the myocardium produced inosin and extracted hypoxanthine. It is suggested that this type of metabolism of adenyl nucleotides requires additional energy expenditures as compared with the energy supply of the nucleotide metabolism of the healthy myocardium and may be one of the reasons underlying the development of tachycardiac paroxysm, with the place of the localization of the re-entry and/or the presence of coronary heart disease having no significant effect on the metabolism of adenyl nucleotides of the myocardium in such patients. The emergence of tachycardia leads to a decreased extraction of hypoxanthine by the myocardium as compared to the baseline and to insignificant elevation in the production of inosin which causes an increase in the levels of these metabolites in the arterial blood and the blood of the coronary sinus.     

Ultrasound of the whole breast utilizing a dedicated automated breast scanner

Innovations in design of a dedicated breast scanner resulted in automation of the scanning process, the production of high resolution images of the whole breast and an efficient mode of image review. The results of clinical evaluation of the prototype of this breast scanner investigating normal breasts as well as benign and malignant breast lesions are presented.     

Sexual differences in mitochondrial and related proteins in rat cerebral microvessels: A proteomic approach

Sex differences in mitochondrial numbers and function are present in large cerebral arteries, but it is unclear whether these differences extend to the microcirculation. We performed an assessment of mitochondria-related proteins in cerebral microvessels (MVs) isolated from young, male and female, Sprague-Dawley rats. MVs composed of arterioles, capillaries, and venules were isolated from the cerebrum and used to perform a 3 versus 3 quantitative, multiplexed proteomics experiment utilizing tandem mass tags (TMT), coupled with liquid chromatography/mass spectrometry (LC/MS). MS data and bioinformatic analyses were performed using Proteome Discoverer version 2.2 and Ingenuity Pathway Analysis. We identified a total of 1969 proteins, of which 1871 were quantified by TMT labels. Sixty-four proteins were expressed significantly (p < 0.05) higher in female samples compared with male samples. Females expressed more mitochondrial proteins involved in energy production, mitochondrial membrane structure, anti-oxidant enzyme proteins, and those involved in fatty acid oxidation. Conversely, males had higher expression levels of mitochondria-destructive proteins. Our findings reveal, for the first time, the full extent of sexual dimorphism in the mitochondrial metabolic protein profiles of MVs, which may contribute to sex-dependent cerebrovascular and neurological pathologies.     

Pharmacogenetics of indirect anticoagulants: value of genotype for improvement of efficacy and safety of therapy

The review is devoted to the contemporary state of the problem of pharmacogenetics of indirect anticoagulants. At present there are data about effects of allele variants of CYP2C9, VKORC1, APOE genes on efficacy and safety of therapy with indirect anticoagulants. Detection of these variants is a perspective way to individualization of therapy with indirect anticoagulants.