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排序方式: 共有1852条查询结果,搜索用时 15 毫秒
31.
Dr. G. Vandeplassche H. R. Lu L. Wouters W. Flameng M. Borgers 《Basic research in cardiology》1991,86(1):21-31
Summary The effect of pretreatment with selective 1-adrenoceptor blockers (dl-nebivolol or atenolol) on myocardial mechanical activity, mitochondrial function, morphology, and calcium cytochemistry was studied during normothermic ischemic arrest and reperfusion of isolated working rabbit hearts. The hearts subjected to 25 min of ischemia followed by 30 min of post-ischemic reperfusion showed typical signs of severe myocardial ischemic damage. The ultrastructural changes showed a good relation with the changes in mechanical activity and mitochondrial function. To determine whether these changes could be prevented or reduced by 1-adrenoceptor blockade, dl-nebivolol or atenolol (0.62 mg/liter) was added to the perfusate 30 min before the induction of ischemia. The results showed that dl-nebivolol exerted a protective effect on recovery of mechanical activity, on mitochondrial function during reperfusion as well as on the ultrastructure as examined at the end of the reperfusion period. On the other hand, atenolol failed to protect the myocardium against ischemia-reperfusion damage in the isolated working rabbit heart. 相似文献
32.
Jim Reid David Price Thys van der Molen Bruno Housset José Jardim Paul Jones Peter Kardos Jean-Fran?ois Muir Pierluigi Paggiaro Stephen Rennard Emiel Wouters 《Primary care respiratory journal》2004,13(2):99-104
A 1-day meeting, attended by invited respiratory and primary-care specialists all of whom had an international profile and a specific interest in Chronic Obstructive Pulmonary Disease (COPD), considered specific research recommendations from the Global Initiative in Obstructive Lung Disease (GOLD) workshop report. Attendees discussed developing a tool to complement spirometry and help primary-care physicians assess treatment success in patients with chronic obstructive pulmonary disease. Discussion focused on the requirement of such a tool, and the limitations of existing tools. Proposals followed for a simple, cost-effective checklist for primary-care. This paper is a consensus report of the discussions from the meeting. Decisions reached on the proposed questionnaire were unanimous. 相似文献
33.
Céspedes-Cruz A Gutiérrez-Suárez R Pistorio A Ravelli A Loy A Murray KJ Gerloni V Wulffraat N Oliveira S Walsh J Penades IC Alpigiani MG Lahdenne P Saad-Magalhães C Cortis E Lepore L Kimura Y Wouters C Martini A Ruperto N;Pediatric Rheumatology International Trials Organization 《Annals of the rheumatic diseases》2008,67(3):309-314
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K DeBoeck M Jorissen K Wouters B Van der Schueren M Eyssen M Casteels-VanDaele L Corbeel 《Pediatric pulmonology》1992,13(4):259-265
We report on ciliary aplasia of the respiratory tract, a rare disorder of the mucociliary apparatus, that is insufficiently recognized as a distinct entity. A culture method for ciliogenesis was developed by our laboratory and offers the advantage of studying cilia free of secondary changes associated with infection. Three cases of primary ciliary aplasia were documented histologically in direct biopsy specimens and also in biopsy specimens cultured specifically for ciliogenesis. Primary ciliary aplasia should be differentiated from secondary ciliary aplasia in which basal bodies are present and ciliogenesis takes place in specific culture. Only hereditary ciliary abnormalities are expressed in cell cultures. We critically review the cases of ciliary aplasia reported to date. 相似文献
37.
Individual quality of life in adults with congenital heart disease: a paradigm shift. 总被引:3,自引:0,他引:3
Philip Moons Kristien Van Deyk Kristel Marquet Els Raes Leentje De Bleser Werner Budts Sabina De Geest 《European heart journal》2005,26(3):298-307
AIMS: During the last decade, a paradigm shift has emerged in the measurement of quality of life, from the use of standard questionnaires towards a more individualized approach. Therefore, this study examined individual quality of life in adults with congenital heart disease and explored potential differences with those reported by matched, healthy control subjects. METHODS AND RESULTS: We examined 579 adults with congenital heart disease. A subsample of 514 of these patients was matched for age, gender, educational level, and employment status with 446 healthy counterparts. Individual quality of life was assessed using the Schedule for the Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW). Twelve domains affecting patients' quality of life were identified. Family, job/education, friends, health, and leisure time were the most prominent quality of life domains. Significantly fewer patients than control subjects considered financial means and material well-being and future to be important determinants of quality of life. CONCLUSION: Assessment of quality of life in adults with congenital heart disease that focusses on the individual is appropriate for obtaining in-depth information on issues relevant for patients' quality of life. This represents a paradigm shift in the measurement of this concept. 相似文献
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