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951.
Shinichi Ueno Fumitake Kubo Masahiko Sakoda Kiyokazu Hiwatashi Taro Tateno Yuko Mataki Kosei Maemura Hiroyuki Shinchi Shoji Natsugoe Takashi Aikou 《Journal of hepato-biliary-pancreatic sciences》2008,15(5):493-500
Background/Purpose
It has been reported that anatomic resection may be preferable to nonanatomic resection for small hepatocellular carcinomas (HCCs), by reducing socalled “micrometastases” (portal venous tumor extension and intrahepatic metastases). Nonanatomic resection or ablation has also been used as therapy for small HCCs. We studied the effectiveness of anatomic resection for small nodular HCCs, especially from the viewpoints of tumor size and gross classification.Methods
A retrospective cohort study was performed in 116 consecutive patients who underwent curative hepatic resection for HCCs 3 cm or smaller and with three or fewer nodules. The outcome of anatomic resection (including segmentectomy, sectoriectomy, and hemihepatectomy) was compared to that of nonanatomic partial hepatectomy.Results
The group that underwent anatomic resection (n = 52) had relatively better overall survival and significantly better recurrence-free survival than those with nonanatomic resection (n = 64). On Cox multivariate analysis, however, liver function was more closely associated with survival. The effect of anatomic resection was more prominent in the subgroup with the nonboundary type nodules (single nodular type with extranodular growth, confluent multinodular type, and invasive type) than in the subgroup with the boundary type (vaguely nodular and single nodular type). Micrometastases in the nonboundary type were found further from the main tumor (9.5 ± 6.2 mm) than those in the boundary type (within 3.1 +-1.4 mm).Conclusions
In patients with HCC nodules equal to or less than 3 cm and with the nonboundary type, anatomic resection should be employed to the extent that liver function allows, because this procedure would be more favorable than nonanatomic resection in eradicating micrometastases that have extended away from the tumor’s margin. 相似文献952.
Seiji Ohtori Sumihisa Orita Kazuyo Yamauchi Yawara Eguchi Nobuyasu Ochiai Shunji Kishida Kazuki Kuniyoshi Yasuchika Aoki Junichi Nakamura Tetsuhiro Ishikawa Masayuki Miyagi Hiroto Kamoda Miyako Suzuki Gou Kubota Yoshihiro Sakuma Yasuhiro Oikawa Kazuhide Inage Takeshi Sainoh Jun Sato Kazuki Fujimoto Yasuhiro Shiga Koki Abe Tomoaki Toyone Gen Inoue Kazuhisa Takahashi 《Yonsei medical journal》2015,56(4):1051-1059
Purpose
Surgery for lumbar spinal degeneration disease is widely performed. While posterior decompression and fusion are popular, anterior lumbar interbody fusion (ALIF) is also used for treatment. Extreme lateral interbody fusion (XLIF) is commonly used for noninvasive ALIF; however, several complications, such as spinal nerve and psoas muscle injury, have been reported. In the current study, we examined the clinical efficacy and complications of oblique lateral interbody fusion (OLIF) for lumbar spinal degeneration disease.Materials and Methods
Thirty-five patients with degenerated spondylolisthesis, discogenic pain, and kyphoscoliosis were examined. All patients underwent OLIF surgery (using a cage and bone graft from the iliac crest) with or without posterior decompression, without real-time electromyography monitoring. Posterior screws were used in all patients. Visual analog scale (VAS) score and Oswestry Disability Index (ODI) were evaluated before and 6 months after surgery. Surgical complications were also evaluated.Results
Pain scores significantly improved after surgery, compared to those before surgery (p<0.05). There was no patient who underwent revision surgery. There was no spinal nerve, major vessel, peritoneal, or urinary injury. Few patients showed symptoms from psoas invasion.Conclusion
OLIF surgery produced good surgical results without any major complication. 相似文献953.
Novel,high‐definition 3‐D endoscopy system with real‐time compression communication system to aid diagnoses and treatment between hospitals in Thailand 下载免费PDF全文
Munenori Uemura Hajime Kenmotsu Morimasa Tomikawa Ryuichi Kumashiro Makoto Yamashita Testuo Ikeda Hiromasa Yamashita Toshio Chiba Koichi Hayashi Eiji Sakae Mitsuo Eguchi Tsuneo Fukuyo Soottiporn Chittmittrapap Patpong Navicharern Pornarong Chotiwan Jirawat Pattana‐arum Makoto Hashizume 《Asian journal of endoscopic surgery》2015,8(2):139-147
954.
Transplanted fibroblast cell sheets promote migration of hepatic progenitor cells in the incised host liver in allogeneic rat model 下载免费PDF全文
Izumi Muraoka Mitsuhisa Takatsuki Yusuke Sakai Tetsuo Tomonaga Akihiko Soyama Masaaki Hidaka Yoshitaka Hishikawa Takehiko Koji Rie Utoh Kazuo Ohashi Teruo Okano Takashi Kanematsu Susumu Eguchi 《Journal of tissue engineering and regenerative medicine》2015,9(11):E108-E115
Cell sheet engineering has been noted as a new and valuable approach in the tissue‐engineering field. The objective of this study was to explore a procedure to induce hepatic progenitor cells and biliary duct structures in the liver. Sprague–Dawley rat dermal fibroblast (DF) sheets were transplanted into the incised surface of the liver of F344 nude rats. In the control group, an incision was made without transplantation of the DF sheets. Bile duct (BD)‐like structures and immature hepatocyte‐like cells were observed in the DF sheet transplant sites. These BD‐like structures were cytokeratin‐8‐positive, while the hepatocyte‐like cells were both OV‐6‐positive and α‐fetoprotein‐positive as well. The proliferation and differentiation of liver progenitor cells were not influenced by hepatectomy. We also transplanted DF sheets transfected with a plasmid encoding the enhanced yellow fluorescent protein target to mitochondria (pEYFP–Mito) by electroporation, and found that the new structures were pEYFP–Mito‐negative. We observed new BD‐like structures and immature hepatocytes after transplantation of DF sheets onto incised liver surfaces, and clarified that the origin of these BD‐like structures and hepatocyte‐like cells was the recipient liver. The present study described an aspect of the hepatic differentiation process induced at the site of liver injury. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
955.
K Matsuo T Kurita M Eguchi K Nakao N Komiya H Kawano S Isomoto G Toda M Hayano K Yano 《Japanese circulation journal》2001,65(11):994-996
A 41-year-old woman with arrhythmogenic right ventricular dysplasia (ARVD) underwent the implantation of an implantable cardioverter-defibrillator (ICD), in which the defibrillator electrode was unusually located in the right ventricular (RV) outflow tract. Although fractionated electrograms were demonstrated in the RV apex, which is the usual site for ICD electrodes, normal electrograms were recorded in the RV outflow tract during an electrophysiologic study. An electrode with a screw-in tip was used to fix the implant in the RV outflow tract and obtain successful defibrillation. If normal electrograms are recorded in the RV outflow tract, the site may prove to be an alternative location for an ICD electrode even for ARVD patients. 相似文献
956.
Differentiation of Lens Tissue from the Progeny of Chick Retinal Pigment Cells Cultured In Vitro: A Demonstration of a Switch of Cell Types in Clonal Cell Culture 总被引:6,自引:2,他引:6 下载免费PDF全文
Goro Eguchi T. S. Okada 《Proceedings of the National Academy of Sciences of the United States of America》1973,70(5):1495-1499
Clonal cell lines isolated from the pigmented retina of 8.5-day chick embryos initially retained the capacity to form pigment. After several passages, however, many cells lost pigment granules and differentiated into lens-like structures. The lens-specific nature of the structures formed in cultures originally derived from retinal pigment cells was established by both ultrastructural and immunological studies. 相似文献
957.
Daisuke Todokoro Hiroshi Eguchi Norihiro Yamada Hirotake Sodeyama Ryuichi Hosoya Shoji Kishi 《Journal of clinical microbiology》2015,53(9):3092-3095
We report the first case of Corynebacterium propinquum keratitis in the compromised cornea of a diabetic patient wearing therapeutic contact lenses. The strain was identified to the species level based on sequencing of the 16S rRNA gene and RNA polymerase β-subunit-encoding gene (rpoB). Ophthalmologists should be aware of nondiphtherial corynebacterial infection of compromised corneas. 相似文献
958.
Kupffer cell activity and hepatic microvascular events after acute ethanol ingestion in mice 总被引:2,自引:0,他引:2
After acute ethanol ingestion in C57Bl/6 mice, phagocytic activity of Kupffer cells and hepatic microcirculation were examined by in vivo and electron microscopy. A ratio of Kupffer cells that phagocytosed 0.8 micron fluorescent latex particles to sinusoids containing blood flow (number of Kupffer cells/number of sinusoids containing blood flow) was used as a measure of Kupffer cell phagocytic activity. Three hours after ingestion of 1 gm/kg ethanol, number of Kupffer cells/number of sinusoids containing blood flow increased in both periportal and centrilobular regions by 62% and 66%, respectively, and blood ethanol was no longer detectable. Ultrastructurally, activation of KC was evidenced by the presence of many pseudopodia and filopodia. Numbers of swollen endothelial cells were increased in both regions by 249% and 174%. Interruption of sinusoidal blood flow by leukocytes was aggravated in both regions by 127% and 167%. Thirty minutes and 3 hr after ingestion of 4 gm/kg ethanol, no significant increase in number of Kupffer cells/number of sinusoids containing blood flow was seen, although number of Kupffer cells were also activated as seen with electron microscopy. An increased number of swollen endothelial cells was observed in both regions by 100% and 71% by 30 min and by 200% and 384% by 3 hr. The interruption of sinusoidal blood flow by leukocytes was also increased (periportal = 161%, centrilobular = 196%) as were sticking or plugging leukocytes in sinusoids (periportal = 320%, centrilobular = 120%) by 3 hr. The diameter of centrilobular sinusoids was decreased by 3 hr. Latex particles and platelets were attached to the sinusoidal wall after both low and high dosing.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
959.
960.
K Sugita H Kurosawa H Sakakibara M Eguchi T Furukawa R Hanada 《Acta haematologica》1992,87(4):198-201
In this paper, we report on a 9-year-old girl with acute nonlymphocytic leukemia (FAB-M5) with a rare chromosome abnormality, t(11;23)(q21;p11). Peripheral blood showed Hb 7.5 g/dl, WBC 3,600 cells/microliters (10% blasts), and platelet count 110 x 10(3) cells/microliters. The bone marrow aspirates showed normal cellularity with 36.7% blasts. On morphological characteristics, micromegakaryocytes were observed, and on chromosome examination the karyotype was shown to be 46,XX,t(11;13)(q21;p11) in all metaphases. 相似文献