全文获取类型
收费全文 | 19930篇 |
免费 | 1060篇 |
国内免费 | 163篇 |
专业分类
耳鼻咽喉 | 218篇 |
儿科学 | 339篇 |
妇产科学 | 313篇 |
基础医学 | 2379篇 |
口腔科学 | 349篇 |
临床医学 | 1190篇 |
内科学 | 5123篇 |
皮肤病学 | 406篇 |
神经病学 | 1753篇 |
特种医学 | 650篇 |
外科学 | 3826篇 |
综合类 | 112篇 |
预防医学 | 502篇 |
眼科学 | 219篇 |
药学 | 1233篇 |
中国医学 | 99篇 |
肿瘤学 | 2442篇 |
出版年
2023年 | 150篇 |
2022年 | 302篇 |
2021年 | 506篇 |
2020年 | 316篇 |
2019年 | 384篇 |
2018年 | 486篇 |
2017年 | 384篇 |
2016年 | 454篇 |
2015年 | 506篇 |
2014年 | 657篇 |
2013年 | 739篇 |
2012年 | 1170篇 |
2011年 | 1269篇 |
2010年 | 685篇 |
2009年 | 643篇 |
2008年 | 1084篇 |
2007年 | 1189篇 |
2006年 | 1218篇 |
2005年 | 1170篇 |
2004年 | 1131篇 |
2003年 | 1084篇 |
2002年 | 976篇 |
2001年 | 351篇 |
2000年 | 403篇 |
1999年 | 372篇 |
1998年 | 242篇 |
1997年 | 222篇 |
1996年 | 163篇 |
1995年 | 133篇 |
1994年 | 109篇 |
1993年 | 123篇 |
1992年 | 187篇 |
1991年 | 177篇 |
1990年 | 205篇 |
1989年 | 203篇 |
1988年 | 185篇 |
1987年 | 166篇 |
1986年 | 185篇 |
1985年 | 171篇 |
1984年 | 114篇 |
1983年 | 91篇 |
1982年 | 64篇 |
1981年 | 50篇 |
1980年 | 49篇 |
1979年 | 73篇 |
1978年 | 58篇 |
1977年 | 55篇 |
1972年 | 56篇 |
1971年 | 47篇 |
1969年 | 55篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
T Akita S Hayase Y Yano K Ogawa H Hiramatsu T Hattori 《Nihon Geka Gakkai zasshi》1990,91(12):1808-1811
Sixty-one and 51-year-old males had progressive walk disturbance after cardiac operations at the intervals of 1 and 2 years. They had received blood transfusion at their operations. Physical examination revealed spastic paraparesis, sensory disturbance of the lower and rectobladder disorder. High titers of anti-Human T-lymphotrophic Virus type-I (HTLV-I) antibody were found in sera and CNF in both cases. They were diagnosed as HTLV-I associated myelopathy (HAM). Because they lived in Aichi Prefecture where the virus is non-epidemic, they were possibly infected through the blood transfusion at their operations. For prevention of HAM, the anti-HTLV-I antibody of all donor blood should be checked before transfusion. 相似文献
62.
Yoko Matsumura Hiromi Kurosawa Kiyozo Morita Koji Nomura Shogo Shimizu Akira Tatara 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2002,50(4):173-177
Optimal initial palliation and a subsequent staged approach is mandatory for high-risk Fontan candidates. We describe the case of mitral atresia with severe tricuspid regurgitation and pulmonary hypertension successfully managed by repeated palliation from the neonatal period and 2-stage Fontan surgery. A 1-month-old boy diagnosed with mitral atresia and double-outlet right ventricle underwent pulmonary artery banding at 1 month of age, followed by repeated pulmonary artery banding accompanied by tricuspid annuloplasty and atrial septal defect enlargement at 6 months. Because of the presence of pulmonary artery distortion, right ventricular dysfunction, and borderline pulmonary vascular resistance, a hemi-Fontan procedure was conducted with extended pulmonary artery plasty when the boy was 3 years and 8 months old. Cardiac catheterization done 3 months after showed improvement in risk factors, and the final Fontan operation (total cavopulmonary connection) was successfully done in conjunction with repeated tricuspid annuloplasty when the boy was 4 years and 5 months old. The patient remains in excellent clinical condition at the last follow-up 5 years after the final Fontan procedure with sinus rhythm and good ventricular function. 相似文献
63.
Takao Hattori MD Toshihiro Hirai Minoru Niimoto Tetsuya Toge Yukihisa Miyoshi Tatsuya Yoshihara Sunao Otagaki Yoshinori Yamashita 《Surgery today》1986,16(2):90-97
Transabdominal resection for esophagocardial cancer and reestablishment of alimentary continuity using bypass methods were
performed in 76 patients. Thirteen underwent a bypass with a gastric tube and in 30, a colonic segment was prepared. In the
remaining 33, a jejunal segment was used as a bypass organ, with considerable success. The 5 year survival rates were 68.8
per cent in those with stages (I+II), 16.5 per cent in those with stage III, 12.6 per cent in those with stage IV and 22.5
per cent in all cases, indicating similar results compared to those with cancer located in the upper third of the stomach
with the limited proximal extension within the esophagocardial junction and operated on during the same period. 相似文献
64.
S Fujimoto M Akahane M Hagisawa T Nakajima T Hattori H Sato T Sugawara K Takeda K Ichinoe N Ishiguro 《The Japanese journal of antibiotics》1986,39(10):2632-2638
The transplacental passage of single intravenous doses of aztreonam (AZT), 1 g or 2 g, was examined in 7 sheep and 14 women in late pregnancy, respectively and the obtained data were analyzed by a two-compartment model. The obtained results were summarized as follows. After single 2 g intravenous doses were given to pregnant sheep, the mean peak level of AZT in maternal blood was 83.79 micrograms/ml and the half-life of the beta-phase was 1.525 hours. After single 1 g intravenous doses were administered to pregnant women, the mean peak level of AZT in blood was 102.62 micrograms/ml and the half-life of beta-phase was 2.128 hours. The peak levels in umbilical venous blood and amniotic fluid were 14.43 micrograms/ml and 11.86 micrograms/ml, respectively. 相似文献
65.
Satoshi Kuwabara Nobuhiro Yuki Michiaki Koga Takamichi Hattori Daisuke Matsuura Masami Miyake Masatoshi Noda 《Annals of neurology》1998,44(2):202-208
To investigate the pathophysiological role of anti-GM1 antibody in Gullain-Barre syndrome (GBS), we reviewed sequential nerve conduction studies of 345 nerves in 34 GBS patients. Statistically significant correlation between IgG anti-GM1 antibodies and electrodiagnoses was found. Sixteen IgG anti-GM1-positive patients were classified as having acute motor sensory axonal neuropathy (AMAN or AMSAN) (12 patients), as having acute inflammatory demyelinating polyneuropathy (AIDP) (3 patientsrpar;, or as undetermined (1 patient) by electrodiagnostic criteria. Besides axonal features, there was rapid resolution of conduction slowing and block. In 3 patients initially diagnosed as having AIDP, conduction slowing was resolved within days, and 1 of them and 3 AMAN patients showed markedly rapid increases in amplitudes of distal compound muscle action potentials that were not accompanied by prolonged duration and polyphasia. The time courses of conduction abnormalities were distinct from those in IgG anti-GM1-negative AIDP patients. Rapid resolution of conduction slowing and block, and the absence of remyelinating slow components, suggest that conduction failure may be caused by impaired physiological conduction at the nodes of Ranvier. Reversible conduction failure as well as axonal degeneration constitutes the pathopsiological mechanisms in IgG anti-GM1)positive GBS. In both cases, immune-mediated attack probably occurs on the axolemma of motor fibers. 相似文献
66.
Shibahara Hiroaki; Shigeta Minoru; Inoue Miyuki; Hasegawa Akiko; Koyama Koji; Alexander Nancy J.; Isojima Sinzo 《Human reproduction (Oxford, England)》1996,11(12):2595-2599
The blocking effects of complement-dependent sperm immobilizingantibodies in the sera of infertile women and monoclonal antispermantibodies against humans and mice on fertilization were investigated.The hemizona assay (HZA) and sperm penetration assay (SPA) wereused to study the inhibitory effects of sera from 22 infertilepatients positive for sperm immobilizing antibodies. Use ofthese tests allowed us to differentiate whether the antibodyblocked spermzona pellucida tight binding and/or spermpenetration into the ooplasm. The zona pellucida penetrationassay (ZPA) was also used to study the effects of four monoclonalantibodies (mAbs) on human sperm penetration into the zona pellucida.Seven mAbs against murine spermatozoa were tested for theirinhibitory effects on in-vitro fertilization (IVF) and HZA inmice. Of 22 patient sera with sperm immobilizing antibodies,21 (95.5%) inhibited HZA attachment and penetration, whereasthis did not occur in any of 13 patient sera without these antibodies.However, 19 of 22 (86.4%) patient sera with sperm immobilizingantibodies and eight of 13 (61.5%) patient sera without theseantibodies inhibited the SPA. Two (2C6, 1G12) of four mAbs againsthuman spermatozoa showed strong inhibitory effects in all theassays (HZA, ZPA and SPA). One mAb (3B10) did not inhibit HZAbut blocked ZPA and SPA. Another mAb (H6-3C4) seemed to haveno inhibitory effects on fertilization. Two (Vx 5 and Vx 8)of seven mAbs against murine spermatozoa inhibited IVF in micebut did not block mouse HZA. These findings suggest that antispermantibodies block fertilization at specific stages. Some of themmay inhibit sperm capacitation and thus prevent all processesof fertilization that follow. Some other antibodies may notaffect capacitation and sperm binding to zona pellucida butinhibit the acrosome reaction, followed by the blocking of spermpenetration through zona pellucida and ooplasm. 相似文献
67.
T Hattori T Iwama H Satoh A Matsuzaki S Mitaka H Satoh 《Nippon Gan Chiryo Gakkai shi》1989,24(10):2447-2450
A 37-year-old male was admitted to our hospital because of epigastric pain and weight loss. He was in a stable state of health until 2 months earlier but gradually worsened and lost weight about 13 kg during 1 month. After 1 month, he consulted our clinic. Upper GI barium studies revealed malignant stenosis in about 50 cm from the ligament of Treitz. Radical surgical resection was performed including the segment in 25 cm of intestine containing the primary tumor. Lymph node and liver metastases were not seen. Pathologic findings revealed "well differentiated adenocarcinoma". Thirteen months after the operation, he is well and has gained weight to state of health. 相似文献
68.
It has been demonstrated that in vivo T cell priming requires CD154-CD40 interaction, which is suggested to be critical in the induction of co-stimulatory activities on antigen-presenting cells (APC). In the current study, we demonstrate that in vivo administration of a high dose of a superantigen, staphylococcal enterotoxin A (SEA), could up-regulate B7-2 on most splenic APC independently of the CD154-CD40 interaction, followed by efficient expansion of SEA-reactive V(beta)3(+) T cells in CD154- or CD40-deficient mice. However, the CD154-CD40 interaction may be involved in SEA-mediated T cell activation, since a contribution of the CD154-CD40 interaction was observed when a lower dose of SEA was injected. CD154-independent T cell priming by SEA appeared also independent of the TRANCE-RANK pathway, which was shown to be capable of mediating CD154-independent activation of naive T cells during the infection of some viruses. These results indicate that SEA, which provokes rapid and efficient T cell responses without adjuvant, could utilize multiple CD154/TRANCE-independent pathways, to prime T cells. 相似文献
69.
Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections. 总被引:12,自引:0,他引:12
Suzuko Moritani Ryoji Kushima Hiroyuki Sugihara Masamichi Bamba Tadao K Kobayashi Takanori Hattori 《Modern pathology》2002,15(4):397-405
CD10, also called common acute lymphoblastic leukemia antigen (CALLA), was recently found to be expressed in nonhematopoietic tissues. Although CD10 was also identified in human breast myoepithelial cells, its availability of immunohistochemistry on paraffin sections has not been examined so far. In the present study, we demonstrated CD10 immunohistochemically on paraffin sections of both normal and pathological breast tissues, comparing its staining patterns to those of smooth muscle actin (SMA), which is now commonly used to highlight myoepithelium. CD10 was consistently positive in normal breast myoepithelial cells. CD10 also clearly highlighted myoepithelial cells in intraductal papilloma, adenosis, ductal hyperplasia, fibroadenoma, and phyllodes tumor as well as SMA did. In atypical ductal hyperplasia and ductal carcinoma in situ, continuous, discontinuous, and totally negative stainings of both CD10 and SMA were noted, depending on foci of neoplastic cell nests. However, both stainings clearly demonstrated myoepithelial cells of cancerized acini, being useful in differentiating lobular cancerization from microinvasion. Because SMA was also positive in normal vessels and spindle-shaped stromal cells, CD10, which was negative in vessels, was useful in differentiating myoepithelial cells from thin vascular wall in intracystic lesions with delicate papillae. Although background staining of spindle-shaped stromal cells was also noted in CD10, the positive cell number was less, and the signal was weaker than that of SMA. The absence of myoepithelial cells in invasive ductal carcinomas was more clearly highlighted by CD10 than SMA. We concluded that CD10 could be another useful marker of breast myoepithelial cells on paraffin sections. Combination of CD10 and SMA will provide more sophisticated information about presence or absence of myoepithelial cells in confusing breast lesions. 相似文献
70.
Seiji Naito Katsuo Sueishi Fumitada Hattori Kenzo Tanaka 《Virchows Archiv : an international journal of pathology》1980,387(3):251-257
Summary Immunological similarities or differences between urokinase and plasminogen activators from 9 lines of cultured human caner cells with varying degrees of fibrinolytic activity were examined with antibodies against human urokinase.The antibodies completely inhibited the fibrinolytic activity of 4 lines of gastric cancer, 2 lines of lung cancer, 1 line of urinary bladder cancer and 1 line of renal cancer, indicating that the plasminogen activators from these cell lines were immunologically identical to urokinase. In 5 out of these cell lines, immunological identity was also confirmed by double diffusion analysis.The plasminogen activator from 1 line of lung cancer was found to be immunologically dissimilar to urokinase by a neutralization experiment and double diffusion analysis.These findings indicate that there are at least two immunologically distinguishable forms of plasminogen activators from human cancer cells. 相似文献