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排序方式: 共有951条查询结果,搜索用时 173 毫秒
101.
Chikashi Terao Koichiro Yano Katsunori Ikari Moritoshi Furu Noriyuki Yamakawa Shinji Yoshida Motomu Hashimoto Hiromu Ito Takao Fujii Koichiro Ohmura Kimiko Yurugi Yasuo Miura Taira Maekawa Atsuo Taniguchi Shigeki Momohara Hisashi Yamanaka Tsuneyo Mimori Fumihiko Matsuda 《Arthritis \u0026amp; Rheumatology》2015,67(7):1744-1750
102.
103.
Kamiya H Otsuka N Ando Y Odaira F Yoshino S Kawano K Takahashi H Nishida T Hidaka Y Toyoizumi-Ajisaka H Shibayama K Kamachi K Sunagawa T Taniguchi K Okabe N 《Emerging infectious diseases》2012,18(7):1166-1169
We describe the epidemiology of a pertussis outbreak in Japan in 2010-2011 and Bordetella holmesii transmission. Six patients were infected; 4 patients were students and a teacher at the same junior high school. Epidemiologic links were found between 5 patients. B. holmesii may have been transmitted from person to person. 相似文献
104.
Mita K Morimyo M Okano K Koike Y Nohata J Kawasaki H Kadono-Okuda K Yamamoto K Suzuki MG Shimada T Goldsmith MR Maeda S 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(24):14121-14126
To build a foundation for the complete genome analysis of Bombyx mori, we have constructed an EST database. Because gene expression patterns deeply depend on tissues as well as developmental stages, we analyzed many cDNA libraries prepared from various tissues and different developmental stages to cover the entire set of Bombyx genes. So far, the Bombyx EST database contains 35,000 ESTs from 36 cDNA libraries, which are grouped into approximately 11,000 nonredundant ESTs with the average length of 1.25 kb. The comparison with FlyBase suggests that the present EST database, SilkBase, covers >55% of all genes of Bombyx. The fraction of library-specific ESTs in each cDNA library indicates that we have not yet reached saturation, showing the validity of our strategy for constructing an EST database to cover all genes. To tackle the coming saturation problem, we have checked two methods, subtraction and normalization, to increase coverage and decrease the number of housekeeping genes, resulting in a 5-11% increase of library-specific ESTs. The identification of a number of genes and comprehensive cloning of gene families have already emerged from the SilkBase search. Direct links of SilkBase with FlyBase and WormBase provide ready identification of candidate Lepidoptera-specific genes. 相似文献
105.
Kobayashi K Seto K Yatsuyanagi J Saito S Terao M Kaneko M Serikawa T Kuramoto S Fujisawa T Suzuki R Yamazaki M Hayashi K Matsune W Yasuoka T Horikawa K Murakami K Kawano K Yamada T Ito K 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2002,76(11):911-920
Diarrheagenic Escherichia coli are differentiated from non-pathogenic members with enterotoxin production, enteroinvasiveness and serotyping. However, the serotypic members are rarely sufficient to reliably identify a strain as diarrheagenic on E. coli. Recently, there are many definite articles which the adhesive E. coli strain against intestinal epithelial cells is enterovirulent. In this study, 1,748 E. coli isolates of diarrheagenic and non-diarrheagenic categories which belonged to EHEC, ETEC, EIEC EPEC and non-EPEC were examinated by PCR method for the presence of eaeA, aggR and bfpA regarding adherence factor genes, and astA of EAST1. The strains examined were recognized to variable carrying geno-patterns, and a large number of EHEC, EPEC and non-EPEC had carried either eaeA or aggR genes. In EHEC isolates, a carrying pattern with the most high frequency was only eaeA, and this type was recognized in the isolates of serotype O157, O26 and O111. EPEC and non-EPEC isolates were recognized eaeA or aggR which harboring with astA or not. Of 508 EPEC isolates from human, a total of 137 isolates (27.0%) carried aggR, and a total of 74 isolates (14.6%) had eaeA, while of the 91 isolates from non-human were recognized aggR and eaeA with 2.2% (2 isolates) and 12.1% (11 isolates), respectively. Also, of 266 non-EPEC isolates from human, a total of 16 isolates (6.0%) carried aggR, and a total of 58 isolates (21.8%) had eaeA. On the other hand, 22 (7.0%) of 316 isolates examined from non-human had eaeA, however no isolate had aggR. Thirteen isolates of EIEC and 218 ETEC isolates were screened, and only 6 ETEC isolates had either eaeA or aggR. The astA gene was recognized in the isolates of all categories, and ETEC strains had more frequently. The bfpA gene was recognized with more frequently in a serotype O157: H45, which is obtained from human with diarrhea, however, this strain was not recognized a member of the EPEC serotype. There is no diagnostic system for the strain of E. coli that cause diarrheal diseases, therefore more laboratories are unable to identify them. The authors had confirmed which PCR technique is a useful simple and rapid method for the detection of adherence factor genes on E. coli strains. From the these results, we showed a differentiation method using PCR technique which have relation with adherence factor, enterotoxin-production and invasiveness, and we firmly believe that application of the procedure is a reasonable and useful method for the identification of diarrheagenic E. coli. 相似文献
106.
Effect of Pranlukast, a Leukotriene Receptor Antagonist, in Patients with Severe Asthma Refractory to Corticosteroids 总被引:1,自引:0,他引:1
Akihito Yokoyama Nobuoki Kohno Kimiko Sakai Yutaka Hirasawa Kei-ichi Kondo Kunio Hiwada 《The Journal of asthma》1998,35(1):57-62
We investigated the effect of pranlukast (ONO-1078), a cysteinyl leukotriene receptor antagonist, in 11 patients with severe bronchial asthma. The patients had been treated with 1600 μg/day of beclomethasone or 800-1600 ug/day of beclomethasone plus 2.5-20 mg/day of prednisolone, but remained symptomatic. After a 2-week baseline period, the patients received 225 mg of pranlukast twice daily for 8 weeks. Morning and evening peak expiratory flow rate (PEF) and symptom scores (cough, dyspnea, sleep) were recorded in an asthma diary. Ten patients completed the study. Symptom scores, especially dyspnea and sleep scores, and the number of rescue β2-agonist inhalations were significantly decreased. The morning PEF significantly improved from a mean baseline value of 311 to 341 L/min by the end of the study period. The evening PEF also improved, from 328 to 348 L/min, although the difference was not significant. These results suggest that pranlukast may be effective in treating patients with severe asthma who are refractory to corticosteroid therapy. 相似文献
107.
Kimiko Fukui Takato Morioka Tadao Kawamura Eiko Hirokawa Shunji Nishio Futoshi Mihara Naoyuki Nakanami Jyunko Yamamoto 《Brain and nerve》2002,54(7):609-614
Subependymal germinal matrix hemorrhage with intraventricular hemorrhage(SEIVH) is a common complication associated with delivery in preterm neonates but has rarely been observed in the fetus. We report a fetus with SEIVH, hydrocephalus and periventricular leukomalacia(PVL). Although this fetus had uneventful prenatal periods, transabdominal ultrasound examination(US) at 33 weeks of pregnancy revealed SEIVH and hydrocephalus, and MRI at 36 weeks did associated PVL. While no events reported that could explain the onset of SEIVH, PVL was considered to be the results of anoxic events associated with SEIVH. In addition to US, information provided by fetal MRI, especially T 2-weighted image, permits a better understanding of the pathophysiology of fetal SEIVH with PVL. 相似文献
108.
Kazutoshi Nakamura Kimiko Ueno Tomoko Nishiwaki Toshiko Saito Yasuo Tsuchiya Masaharu Yamamoto 《Magnesium research》2007,20(4):250-253
The purpose of this study was to determine a possible association between magnesium intake and bone mass in young adult women. Subjects consisted of 106 female university students aged 19-25 years. Calcium and magnesium intakes were evaluated using the duplicate sampling method on three weekdays. Spinal and femoral bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. Mean magnesium intake was 139 mg/day (median 127, SD 54). The correlation between magnesium intake and BMD was of borderline significance (r = 0.175, p = 0.073) for the femoral neck, and was insignificant (r = 0.084, p = 0.391) for the lumbar spine. However, the partial correlation between magnesium intake and BMD of the femoral neck (r = -0.027, p = 0.788), adjusted for calcium intake, was not significant. In conclusion, we did not find an association between magnesium intake and bone mass in young women, and calcium intake needs to be included as an important, potential confounding factor when exploring such an association. 相似文献
109.
110.
Tadashi Matsuo M.D. Reiko Nose M.A. Keiko Yoshida M.D. Naohiro Fujikawa M.D. Kimiko Takagi M.A. Yoshiaki Nose M.D. Koichi Ikari M.D. 《Psychiatry and clinical neurosciences》1985,39(4):473-484
Abstract: Two hundred and sixty-eight Japanese aged 19 or below were studied retrospectively from their medical records to determine the relationship between the sibship size (number of siblings in the family) and the appearance of symptoms of anxiety, hypochondriasis and depression during the time period I (1955 + 1960 + 1965) and the time period II (1970 + 1975 + 1978). The results showed that only sons and either sex of a large sibship size (4 or more) possessed these three symptoms to a larger extent than only daughters and either sex of a medium sibship size (2 or 3) during both time periods. These three adult-type neurotic symptoms were thought to be manifested among the children and adolescents who communicated primarily with adults and/or those who were required by their parents to exhibit adult-type behavior whether in traditional or in modern Japanese families. 相似文献