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941.
Somatic MECOM mosaicism in a patient with congenital bone marrow failure without a radial abnormality 下载免费PDF全文
Tomoo Osumi Shin‐ichi Tsujimoto Kazuhiko Nakabayashi Maki Taniguchi Ryota Shirai Masanori Yoshida Toru Uchiyama Junko Nagasawa Susumu Goyama Takako Yoshioka Daisuke Tomizawa Mineo Kurokawa Yoichi Matsubara Nobutaka Kiyokawa Kimikazu Matsumoto Kenichiro Hata Motohiro Kato 《Pediatric blood & cancer》2018,65(6)
942.
Yuko Hirata Shin-ichiro Hamano Satoru Ikemoto Atsuko Oba Ryuki Matsuura 《Brain & development》2018,40(10):841-849
Objective
To quantitatively evaluate regional cerebral blood flow (rCBF) and regional developmental changes during childhood using 123I-N-isopropyl-iodoamphetamine single-photon emission computed tomography (SPECT) and autoradiography.Methods
We retrospectively analyzed quantitative values of rCBF in 75 children (29 girls) aged between 16?days and 178?months (median: 12?months), whose brain images, including magnetic resonance imaging and SPECT data, were normal under visual inspection at Saitama Children’s Medical Center between 2005 and 2015. The subjects had normal psychomotor development, no focal neurological abnormalities, and neither respiratory nor cardiac disease at the time of examination. Regions of interest were placed automatically using a three-dimensional stereotactic template.Results
rCBF was lowest in neonates, who had greater rCBF in the lenticular nucleus, thalamus, and cerebellum than the cerebral cortices. rCBF increased rapidly during the first year of life, reaching approximately twice the adult levels at 8?years, and then fell to approximately adult levels in the late teenage years. Cerebral cortex rCBF sequentially increased in the posterior, central, parietal, temporal, and callosomarginal regions during infancy and childhood.Conclusions
rCBF changed dramatically throughout childhood and ranged from lower than adult values to approximately two times higher than adult values. It had different trajectories in each region during brain development. Understanding this dynamic developmental change is necessary for SPECT image evaluation in children. 相似文献943.
Takashi Saito Atsuo Okamura Junichiro Inoue Daisuke Makiura Hisayo Doi Kimikazu Yakushijin Hiroshi Matsuoka Yoshitada Sakai Rei Ono 《Oncology research》2019,27(4):469-474
Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving
R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation
of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed
a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty
patients (indolent lymphoma, n=9; diffuse large B-cell lymphoma; n=31) received R-CHOP therapy from
September 2009 to July 2014. The median age of patients was 58 years (range=27–76 years). Statistical analyses were applied to the patients, who were divided into two groups: mild CIPN (no symptoms or grade 1
according to the CTCAE version 3.0 program) and severe CIPN patients (grade 2 or higher). Forward stepwise
logistic regression analyses were performed using the following variables: sex, BMI, BSA, hyperglycemia,
malnutrition, and anemia. Severe CIPN occurred in seven patients (17.5%). Gender and anemia remained
following the stepwise procedure, and anemia predicted severe CIPN significantly (OR=19.45, 95% confidence interval=1.52–171.12). Our study suggests that anemia at initial diagnosis could be a predictive factor
of R-CHOP-induced CIPN. 相似文献
944.
Hanada K Ikari S Koukaki Y Utena A Kimura T Hamano K Ariki H Masuhara K Ogata H 《Biological & pharmaceutical bulletin》2007,30(5):952-954
Teicoplanin is a glycopeptide antibiotic comprising six closely related major components whose activities against specific microbial species differ. In order to clarify the significance of monitoring these components separately for determining the therapeutic effectiveness of teicoplanin, we measured the total and unbound concentrations of the main teicoplanin components in plasma and the unbound fractions in patients. Teicoplanin components in plasma were determined separately by high-performance liquid chromatography following a co-extractive clean-up procedure. The concentrations of unbound teicoplanin components were estimated after plasma ultrafiltration. The plasma concentrations of the main components of teicoplanin were strongly correlated with each other. The apparent elimination rate constants of total bound and unbound teicoplanin calculated by population pharmacokinetic parameters were almost same among the components. Furthermore, the mean population unbound clearance corrected by the unbound fraction was almost the same among the components. These results suggest that monitoring the individual components of teicoplanin has no clinical significance based on the pharmacokinetics of teicoplanin. 相似文献
945.
Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis 总被引:3,自引:0,他引:3
Hamano H Arakura N Muraki T Ozaki Y Kiyosawa K Kawa S 《Journal of gastroenterology》2006,41(12):1197-1205
Background Autoimmune pancreatitis is a unique form of chronic pancreatitis characterized by high serum IgG4 concentrations and abundant
IgG4-bearing plasma cell infiltration in the pancreatic lesion, and it has been reported to be associated with a variety of
extrapancreatic lesions, leading us to postulate the concept of a systemic inflammatory disease. To confirm this, we clarified
the exact distribution of these extrapancreatic lesions and provide a panoramic view of them.
Methods The frequency, distribution, clinical characteristics, and pathology of five extrapancreatic lesions were determined in 64
patients with autoimmune pancreatitis by examining clinical and laboratory findings.
Results The most frequent extrapancreatic lesion was hilar lymphadenopathy (80.4%), followed by extrapancreatic bile duct lesions
(73.9%), lachrymal and salivary gland lesions (39.1%), hypothyroidism (22.2%), and retroperitoneal fibrosis (12.5%). No patients
had all five types of lesions. Patients with hilar lymphadenopathy or lachrymal and salivary gland lesions were found to have
significantly higher IgG4 levels than those without (P = 0.0042 and 0.0227, respectively). Patients with three lesions were found to have significantly higher IgG4 levels than
those with no lesion, suggesting that patients with multiple extrapancreatic lesions have active disease. Similar to pancreatic
lesions, extrapancreatic lesions have a characteristic histological finding of abundant IgG4-bearing plasma cell infiltration,
and they respond favorably to corticosteroid therapy.
Conclusions Autoimmune pancreatitis was recognized as a systemic inflammatory disease. Furthermore, recognition of these characteristic
findings will aid in the correct diagnosis of this disease. 相似文献
946.
Takano M Iwadare J Ohba H Takamura H Masuda Y Matsuo K Kanai T Ieda H Hattori Y Kurata S Koganezawa S Hamano K Tsuchiya S 《International journal of colorectal disease》2006,21(1):44-51
Background and aims Patients with prolapsing internal hemorrhoids were treated with a novel sclerosing agent (OC-108), and the results were compared with surgery of ligation and excision.Patients and methods This study included 20 years or older patients with prolapsing internal hemorrhoids who visited ten medical institutions in Japan from October 2000 to October 2002. Investigation on surgery was also performed.Results Comparing OC-108 and surgery in patients with third- and fourth-degree internal hemorrhoids according to the Golighers classification, for which surgery has been generally indicated, at 28 days after treatment, the disappearance rate of prolapse was similar between OC-108 and surgery, 94% (75/80 patients) and 99% (84/85 patients), respectively. The 1-year recurrence rate was 16% (12/73 patients) in the OC-108 group, and this value was satisfactory because of its less invasive nature while it was more or less higher compared with 2% (2/81 patients) in the surgery group. The incidences of pain and bleeding were lower in the OC-108 group.Conclusions OC-108 is a useful alternative treatment for hemorrhoids.Presented in part at the meeting of the 58th Annual Meeting of the Japan Society of Coloproctology, Nagoya, Japan, November 7 to 8, 2003 相似文献
947.
Kawano M Yamada K Kakuchi Y Ito K Hamano R Fujii H Inoue R Matsumura M Takahira M Zen Y Yachie A Nakashima A Yamagishi M 《Modern rheumatology / the Japan Rheumatism Association》2009,19(1):87-90
We describe a 64-year-old woman with chronic sclerosing sialadenitis and dacryoadenitis, which developed during treatment for cervical lymph node tuberculosis. Anti-tuberculosis treatment did not improve the swelling in the lacrimal and submandibular glands, and a biopsy specimen of the lacrimal gland showed inflammation, with abundant lymphoid follicles with fibrosis and granuloma without caseous necrosis. Immunohistological examination of a repeat biopsy specimen showed abundant immunoglobulin (Ig) G4-positive plasma cell infiltration. Corticosteroid therapy improved the salivary gland swelling without reactivation of the tuberculosis. This case suggests that an abnormal immunological reaction to tuberculosis may be one of the etiological candidates for IgG4-related disease. 相似文献
948.
Sugimura K Miyata H Tanaka K Hamano R Takahashi T Kurokawa Y Yamasaki M Nakajima K Takiguchi S Mori M Doki Y 《Clinical cancer research》2012,18(18):5144-5153
949.
950.
Hamano R Miyata H Yamasaki M Sugimura K Tanaka K Kurokawa Y Nakajima K Takiguchi S Fujiwara Y Mori M Doki Y 《British journal of cancer》2012,106(8):1415-1423